1IIU

Chicken plasma retinol-binding protein (RBP)

Summary for 1IIU

• Entry DOI: 10.2210/pdb1iiu/pdb
• Related: 1AQB 1HBP 1HBQ 1RBP
• Descriptor: plasma retinol-binding protein, CADMIUM ION, RETINOL, ... (4 entities in total)
• Functional Keywords: rbp, retinol, transport protein
• Biological source: Gallus gallus (chicken)
• Cellular location: Secreted : P41263
• Total number of polymer chains: 1
• Total formula weight: 20504.40

Authors

Zanotti, G.,Calderone, V.,Berni, R. (deposition date: 2001-04-24, release date: 2002-01-16, Last modification date: 2024-11-06)

Primary citation

Zanotti, G.,Calderone, V.,Beda, M.,Malpeli, G.,Folli, C.,Berni, R.
Structure of Chicken plasma retinol-binding protein
BIOCHIM.BIOPHYS.ACTA, 1550:64-69, 2001

PubMed Abstract: The crystal structure of the specific carrier of retinol (retinol-binding protein, RBP) purified from chicken plasma has been determined (space group P2(1)2(1)2(1), with a=46.06(5) A, b=53.56(6) A, c=73.41(8) A, and one protein molecule in the asymmetric unit). Despite being obtained from a species phylogenetically distant from mammals, chicken holoRBP has an overall structure that closely resembles the previously determined structures of mammalian holoRBPs. The lack in chicken RBP of eight carboxy-terminal amino acid residues characteristic of mammalian RBPs does not significantly affect the protein structure. A distinctive feature of the avian protein is a better definition of the loop 63-67, close to the opening of the beta-barrel cavity accommodating the retinol molecule, which is rather disordered in the structures of mammalian RBPs.

PubMed: 11738088
DOI: 10.1016/S0167-4838(01)00268-0

Experimental method

X-RAY DIFFRACTION (2.5 Å)