8FRT

X-ray crystal structure of the N-terminal region from HCMV US11 binding to HLA-A*02:01

Summary for 8FRT

Entry DOI	10.2210/pdb8frt/pdb
Descriptor	Unique short US11 glycoprotein, Beta-2-microglobulin, MHC class I HLA-A fusion, GLYCEROL (3 entities in total)
Functional Keywords	immunoevasin, molecular mimicry, immune system
Biological source	Human cytomegalovirus (strain AD169) (HHV-5) More
Total number of polymer chains	1
Total formula weight	49748.74
Authors	Watson, G.M.,Berry, R.,Rossjohn, J. (deposition date: 2023-01-08, release date: 2024-03-27)
Primary citation	Zimmermann, C.,Watson, G.M.,Bauersfeld, L.,Berry, R.,Ciblis, B.,Lan, H.,Gerke, C.,Oberhardt, V.,Fuchs, J.,Hofmann, M.,Freund, C.,Rossjohn, J.,Momburg, F.,Hengel, H.,Halenius, A. Diverse cytomegalovirus US11 antagonism and MHC-A evasion strategies reveal a tit-for-tat coevolutionary arms race in hominids. Proc.Natl.Acad.Sci.USA, 121:e2315985121-e2315985121, 2024 Cited by PubMed: 38377192 DOI: 10.1073/pnas.2315985121 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation