5IM3
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6VJ3
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![BU of 6vj3 by Molmil](/molmil-images/mine/6vj3) | Carbonic Anhydrase II in complex with pyrimidine-based inhibitor | 分子名称: | 2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-N-(4-sulfamoylphenyl)acetamide, Carbonic anhydrase 2, GLYCEROL, ... | 著者 | Lomelino, C.L, McKenna, R. | 登録日 | 2020-01-14 | 公開日 | 2020-03-11 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | Inclusion of a 5-fluorouracil moiety in nitrogenous bases derivatives as human carbonic anhydrase IX and XII inhibitors produced a targeted action against MDA-MB-231 and T47D breast cancer cells. Eur.J.Med.Chem., 190, 2020
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7DVQ
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![BU of 7dvq by Molmil](/molmil-images/mine/7dvq) | Cryo-EM Structure of the Activated Human Minor Spliceosome (minor Bact Complex) | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, 5'-O-[(S)-hydroxy{[(R)-hydroxy{[(S)-hydroxy(methoxy)phosphoryl]oxy}phosphoryl]oxy}phosphoryl]guanosine, Armadillo repeat-containing protein 7, ... | 著者 | Bai, R, Wan, R, Wang, L, Xu, K, Zhang, Q, Lei, J, Shi, Y. | 登録日 | 2021-01-14 | 公開日 | 2021-03-31 | 実験手法 | ELECTRON MICROSCOPY (2.89 Å) | 主引用文献 | Structure of the activated human minor spliceosome. Science, 371, 2021
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7AQT
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![BU of 7aqt by Molmil](/molmil-images/mine/7aqt) | NMR2 structure of BRD4-BD2 in complex with iBET-762 | 分子名称: | 2-[(4S)-6-(4-chlorophenyl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-ethylacetamide, Bromodomain-containing protein 4 | 著者 | Orts, J, Torres, F, Milbradt, A.G, Walser, R. | 登録日 | 2020-10-23 | 公開日 | 2022-03-02 | 最終更新日 | 2024-06-19 | 実験手法 | SOLUTION NMR | 主引用文献 | NMR Molecular Replacement Provides New Insights into Binding Modes to Bromodomains of BRD4 and TRIM24. J.Med.Chem., 65, 2022
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2E9R
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![BU of 2e9r by Molmil](/molmil-images/mine/2e9r) | Foot-and-mouth disease virus RNA-dependent RNA polymerase in complex with a template-primer RNA and with ribavirin | 分子名称: | 5'-R(*CP*AP*UP*GP*GP*GP*CP*CP*C)-3', 5'-R(*CP*CP*C*GP*GP*GP*CP*CP*C)-3', MAGNESIUM ION, ... | 著者 | Ferrer-Orta, C, Arias, A, Perez-Luque, R, Escarmis, C, Domingo, E, Verdaguer, N. | 登録日 | 2007-01-26 | 公開日 | 2007-06-26 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.81 Å) | 主引用文献 | Sequential structures provide insights into the fidelity of RNA replication Proc.Natl.Acad.Sci.Usa, 104, 2007
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7ACC
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2VIJ
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![BU of 2vij by Molmil](/molmil-images/mine/2vij) | Human BACE-1 in complex with 3-(1,1-dioxidotetrahydro-2H-1,2-thiazin- 2-yl)-5-(ethylamino)-N-((1S,2R)-2-hydroxy-1-(phenylmethyl)-3-(1,2,3,4- tetrahydro-1-naphthalenylamino)propyl)benzamide | 分子名称: | BETA-SECRETASE 1, N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(1S)-1,2,3,4-tetrahydronaphthalen-1-ylamino]propyl}-3-(1,1-dioxido-1,2-thiazinan-2-yl)-5-(ethylamino)benzamide | 著者 | Beswick, P, Charrier, N, Clarke, B, Demont, E, Dingwall, C, Dunsdon, R, Faller, A, Gleave, R, Hawkins, J, Hussain, I, Johnson, C.N, Macpherson, D, Maile, G, Matico, R, Milner, P, Mosley, J, Naylor, A, O'Brien, A, Redshaw, S, Riddell, D, Rowland, P, Skidmore, J, Soleil, V, Smith, K.J, Stanway, S, Stemp, G, Stuart, A, Sweitzer, S, Theobald, P, Vesey, D, Walter, D.S, Ward, J, Wayne, G. | 登録日 | 2007-12-04 | 公開日 | 2008-01-29 | 最終更新日 | 2019-09-18 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Bace-1 Inhibitors Part 3: Identification of Hydroxy Ethylamines (Heas) with Nanomolar Potency in Cells. Bioorg.Med.Chem.Lett., 18, 2008
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6R2J
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![BU of 6r2j by Molmil](/molmil-images/mine/6r2j) | Crystal Structure of Pseudomonas stutzeri endoglucanase Cel5A in complex with cellobiose | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Endoglucanase(Endo-1,4-beta-glucanase)protein, beta-D-glucopyranose-(1-4)-beta-D-glucopyranose | 著者 | Dutoit, R, Delsaute, M, Berlemont, R, Van Elder, D, Galleni, M, Bauvois, C. | 登録日 | 2019-03-18 | 公開日 | 2020-01-29 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.44 Å) | 主引用文献 | Crystal structure determination of Pseudomonas stutzeri A1501 endoglucanase Cel5A: the search for a molecular basis for glycosynthesis in GH5_5 enzymes. Acta Crystallogr D Struct Biol, 75, 2019
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2EC0
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![BU of 2ec0 by Molmil](/molmil-images/mine/2ec0) | RNA-dependent RNA polymerase of foot-and-mouth disease virus in complex with a template-primer RNA and ATP | 分子名称: | 5'-R(*GP*GP*GP*CP*CP*CP*A)-3', 5'-R(P*AP*UP*GP*GP*GP*CP*CP*C)-3', MAGNESIUM ION, ... | 著者 | Ferrer-Orta, C, Arias, A, Perez-Luque, R, Escarmis, C, Domingo, E, Verdaguer, N. | 登録日 | 2007-02-09 | 公開日 | 2007-06-26 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Sequential structures provide insights into the fidelity of RNA replication Proc.Natl.Acad.Sci.Usa, 104, 2007
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6WH5
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![BU of 6wh5 by Molmil](/molmil-images/mine/6wh5) | Mycobacterium tuberculosis pduO-type ATP:cobalamin adenosyltransferase bound to cob(II)alamin and PPPi | 分子名称: | COBALAMIN, Corrinoid adenosyltransferase, MAGNESIUM ION, ... | 著者 | Mascarenhas, R.N, Ruetz, M, Koutmos, M, Banerjee, R. | 登録日 | 2020-04-07 | 公開日 | 2021-01-20 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.866 Å) | 主引用文献 | Mobile loop dynamics in adenosyltransferase control binding and reactivity of coenzyme B 12 . Proc.Natl.Acad.Sci.USA, 117, 2020
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6UG5
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6ZMN
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6UL4
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6ZVI
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![BU of 6zvi by Molmil](/molmil-images/mine/6zvi) | Mbf1-ribosome complex | 分子名称: | 18S rRNA, 40S ribosomal protein S0-A, 40S ribosomal protein S10-A, ... | 著者 | Best, K.M, Denk, T, Cheng, J, Thoms, M, Berninghausen, O, Beckmann, R. | 登録日 | 2020-07-24 | 公開日 | 2020-09-09 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | EDF1 coordinates cellular responses to ribosome collisions. Elife, 9, 2020
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6XNR
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![BU of 6xnr by Molmil](/molmil-images/mine/6xnr) | Crystal structure of Rhagium Mordax antifreeze protein | 分子名称: | 1,2-ETHANEDIOL, Antifreeze protein | 著者 | Ye, Q, Eves, R, Campbell, R.L, Davies, P.L. | 登録日 | 2020-07-04 | 公開日 | 2020-08-26 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Crystal structure of an insect antifreeze protein reveals ordered waters on the ice-binding surface. Biochem.J., 477, 2020
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8AES
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6VLG
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![BU of 6vlg by Molmil](/molmil-images/mine/6vlg) | Crystal structure of mouse alpha 1,6-fucosyltransferase, FUT8 bound to GDP | 分子名称: | Alpha-(1,6)-fucosyltransferase, GUANOSINE-5'-DIPHOSPHATE, SULFATE ION, ... | 著者 | Jarva, M.A, Dramicanin, M, Lingford, J.P, Mao, R, John, A, Goddard-Borger, E.D. | 登録日 | 2020-01-23 | 公開日 | 2020-02-26 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural basis of substrate recognition and catalysis by fucosyltransferase 8. J.Biol.Chem., 295, 2020
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6ZVH
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![BU of 6zvh by Molmil](/molmil-images/mine/6zvh) | EDF1-ribosome complex | 分子名称: | 18S rRNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... | 著者 | Best, K.M, Denk, T, Cheng, J, Thoms, M, Berninghausen, O, Beckmann, R. | 登録日 | 2020-07-24 | 公開日 | 2020-08-19 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | EDF1 coordinates cellular responses to ribosome collisions. Elife, 9, 2020
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7DCP
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![BU of 7dcp by Molmil](/molmil-images/mine/7dcp) | cryo-EM structure of the DEAH-box helicase Prp2 and coactivator Spp2 | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PRP2 isoform 1, ... | 著者 | Bai, R, Wan, R, Yan, C, Jia, Q, Zhang, P, Lei, J, Shi, Y. | 登録日 | 2020-10-26 | 公開日 | 2021-01-06 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.15 Å) | 主引用文献 | Mechanism of spliceosome remodeling by the ATPase/helicase Prp2 and its coactivator Spp2. Science, 371, 2021
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6TEG
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![BU of 6teg by Molmil](/molmil-images/mine/6teg) | Crystal structure of monooxygenase RutA complexed with uracil and dioxygen under 1.5 MPa / 15 bars of oxygen pressure. | 分子名称: | FLAVIN MONONUCLEOTIDE, OXYGEN MOLECULE, Pyrimidine monooxygenase RutA, ... | 著者 | Saleem-Batcha, R, Matthews, A, Teufel, R. | 登録日 | 2019-11-11 | 公開日 | 2020-02-05 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Aminoperoxide adducts expand the catalytic repertoire of flavin monooxygenases. Nat.Chem.Biol., 16, 2020
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4PFQ
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![BU of 4pfq by Molmil](/molmil-images/mine/4pfq) | Crystal structure of hypoxanthine phosphoribosyltransferase from Brachybacterium faecium DSM 4810, NYSGRC Target 029763. | 分子名称: | Hypoxanthine phosphoribosyltransferase, MAGNESIUM ION | 著者 | Malashkevich, V.N, Bhosle, R, Toro, R, Hillerich, B, Gizzi, A, Garforth, S, Kar, A, Chan, M.K, Lafluer, J, Patel, H, Matikainen, B, Chamala, S, Lim, S, Celikgil, A, Villegas, G, Evans, B, Love, J, Fiser, A, Seidel, R, Bonanno, J.B, Almo, S.C, New York Structural Genomics Research Consortium (NYSGRC) | 登録日 | 2014-04-30 | 公開日 | 2014-07-02 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Crystal structure of hypoxanthine phosphoribosyltransferase from Brachybacterium faecium DSM 4810, NYSGRC Target 0299763. to be published
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6TEM
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![BU of 6tem by Molmil](/molmil-images/mine/6tem) | CENP-A nucleosome core particle with 145 base pairs of the Widom 601 sequence by cryo-EM | 分子名称: | Histone H2A, Histone H2B 1.1, Histone H3-like centromeric protein A, ... | 著者 | Boopathi, R, Danev, R, Petosa, C, Bednar, J. | 登録日 | 2019-11-12 | 公開日 | 2020-04-08 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Phase-plate cryo-EM structure of the Widom 601 CENP-A nucleosome core particle reveals differential flexibility of the DNA ends. Nucleic Acids Res., 48, 2020
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8GLB
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![BU of 8glb by Molmil](/molmil-images/mine/8glb) | Selenomethionine Derivatized Citrate Synthase (CitA) in Mycobacterium tuberculosis with Pyruvate | 分子名称: | 1,2-ETHANEDIOL, PYRUVIC ACID, citrate synthase | 著者 | Pathirage, R, Ronning, D, Favrot, L. | 登録日 | 2023-03-21 | 公開日 | 2023-06-07 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Mycobacterium tuberculosis CitA activity is modulated by cysteine oxidation and pyruvate binding. Rsc Med Chem, 14, 2023
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8GMI
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6Y7S
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![BU of 6y7s by Molmil](/molmil-images/mine/6y7s) | 2.85 A cryo-EM structure of the in vivo assembled type 1 pilus rod | 分子名称: | Type-1 fimbrial protein, A chain | 著者 | Zyla, D, Hospenthal, M, Waksman, G, Glockshuber, R. | 登録日 | 2020-03-02 | 公開日 | 2021-03-31 | 最終更新日 | 2024-04-17 | 実験手法 | ELECTRON MICROSCOPY (2.85 Å) | 主引用文献 | The assembly platform FimD is required to obtain the most stable quaternary structure of type 1 pili. Nat Commun, 15, 2024
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