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PDB: 21 件
5XJY
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BU of 5xjy by Molmil
Cryo-EM structure of human ABCA1
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ATP-binding cassette sub-family A member 1, ...
著者Qian, H.W, Yan, N, Gong, X.
登録日2017-05-04
公開日2017-06-07
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (4.1 Å)
主引用文献Structure of the Human Lipid Exporter ABCA1.
Cell, 169, 2017
8GYX
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BU of 8gyx by Molmil
Cryo-EM structure of human CEPT1
分子名称: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Choline/ethanolaminephosphotransferase 1, MAGNESIUM ION
著者Qian, H.W, Wang, Z.H.
登録日2022-09-24
公開日2023-03-22
最終更新日2023-10-04
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献Structural basis for catalysis of human choline/ethanolamine phosphotransferase 1.
Nat Commun, 14, 2023
8GYW
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BU of 8gyw by Molmil
Cryo-EM structure of human CEPT1 complexed with CDP-choline
分子名称: Choline/ethanolaminephosphotransferase 1, MAGNESIUM ION, [2-CYTIDYLATE-O'-PHOSPHONYLOXYL]-ETHYL-TRIMETHYL-AMMONIUM
著者Qian, H.W, Wang, Z.H.
登録日2022-09-24
公開日2023-03-22
最終更新日2023-10-04
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献Structural basis for catalysis of human choline/ethanolamine phosphotransferase 1.
Nat Commun, 14, 2023
6W5U
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BU of 6w5u by Molmil
NPC1 structure in GDN micelles at pH 5.5, conformation b
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ...
著者Yan, N, Qian, H.W, Wu, X.L.
登録日2020-03-13
公開日2020-06-17
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献Structural Basis of Low-pH-Dependent Lysosomal Cholesterol Egress by NPC1 and NPC2.
Cell, 182, 2020
6W5T
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BU of 6w5t by Molmil
NPC1 structure in GDN micelles at pH 5.5, conformation a
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ...
著者Yan, N, Qian, H.W, Wu, X.L.
登録日2020-03-13
公開日2020-06-17
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献Structural Basis of Low-pH-Dependent Lysosomal Cholesterol Egress by NPC1 and NPC2.
Cell, 182, 2020
5GRS
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BU of 5grs by Molmil
Complex structure of the fission yeast SREBP-SCAP binding domains
分子名称: Sterol regulatory element-binding protein 1, Sterol regulatory element-binding protein cleavage-activating protein
著者Gong, X, Qian, H.W, Wu, J.P, Yan, N.
登録日2016-08-12
公開日2016-12-14
最終更新日2019-10-23
実験手法ELECTRON MICROSCOPY (5.4 Å)
主引用文献Complex structure of the fission yeast SREBP-SCAP binding domains reveals an oligomeric organization
Cell Res., 26, 2016
5GPD
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BU of 5gpd by Molmil
Crystal structure of the binding domain of SREBP from fission yeast
分子名称: Sterol regulatory element-binding protein 1
著者Gong, X, Qian, H.W, Wu, J.P, Yan, N.
登録日2016-08-01
公開日2016-11-23
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (3.501 Å)
主引用文献Complex structure of the fission yeast SREBP-SCAP binding domains reveals an oligomeric organization
Cell Res., 26, 2016
6P2J
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BU of 6p2j by Molmil
Dimeric structure of ACAT1
分子名称: S-{(3R,5R,9R)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-3,5-dioxido-10,14-dioxo-2,4,6-trioxa-11,15-diaza-3lambda~5~,5lambda~5~-diphosphaheptadecan-17-yl} (9Z)-octadec-9-enethioate (non-preferred name), Sterol O-acyltransferase 1
著者Yan, N, Qian, H.W.
登録日2019-05-21
公開日2020-05-20
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Structural basis for catalysis and substrate specificity of human ACAT1.
Nature, 581, 2020
6P2P
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Tetrameric structure of ACAT1
分子名称: S-{(3R,5R,9R)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-3,5-dioxido-10,14-dioxo-2,4,6-trioxa-11,15-diaza-3lambda~5~,5lambda~5~-diphosphaheptadecan-17-yl} (9Z)-octadec-9-enethioate (non-preferred name), Sterol O-acyltransferase 1
著者Yan, N, Qian, H.W.
登録日2019-05-21
公開日2020-05-20
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Structural basis for catalysis and substrate specificity of human ACAT1.
Nature, 581, 2020
5JNX
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BU of 5jnx by Molmil
The 6.6 A cryo-EM structure of the full-length human NPC1 in complex with the cleaved glycoprotein of Ebola virus
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein, ...
著者Gong, X, Qian, H.W, Zhou, X.H, Wu, J.P, Wan, T, Shi, Y, Gao, F, Zhou, Q, Yan, N.
登録日2016-05-01
公開日2016-06-15
最終更新日2020-08-05
実験手法ELECTRON MICROSCOPY (6.56 Å)
主引用文献Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection
Cell, 165, 2016
6W5S
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BU of 6w5s by Molmil
NPC1 structure in GDN micelles at pH 8.0
分子名称: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Yan, N, Qian, H.W, Wu, X.L.
登録日2020-03-13
公開日2020-06-17
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Structural Basis of Low-pH-Dependent Lysosomal Cholesterol Egress by NPC1 and NPC2.
Cell, 182, 2020
6W5V
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BU of 6w5v by Molmil
NPC1-NPC2 complex structure at pH 5.5
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ...
著者Yan, N, Qian, H.W, Wu, X.L.
登録日2020-03-13
公開日2020-06-17
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (4 Å)
主引用文献Structural Basis of Low-pH-Dependent Lysosomal Cholesterol Egress by NPC1 and NPC2.
Cell, 182, 2020
6W5R
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BU of 6w5r by Molmil
NPC1 structure in Nanodisc
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ...
著者Yan, N, Qian, H.W, Wu, X.L.
登録日2020-03-13
公開日2020-06-17
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献Structural Basis of Low-pH-Dependent Lysosomal Cholesterol Egress by NPC1 and NPC2.
Cell, 182, 2020
3JD8
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BU of 3jd8 by Molmil
cryo-EM structure of the full-length human NPC1 at 4.4 angstrom
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ...
著者Gong, X, Qian, H.W, Zhou, X.H, Wu, J.P, Zhou, Q, Yan, N.
登録日2016-05-01
公開日2016-06-01
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (4.43 Å)
主引用文献The structure of Niemann-Pick C1 protein
To Be Published
6DMB
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BU of 6dmb by Molmil
Cryo-EM structure of human Ptch1
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, ...
著者Yan, N, Gong, X, Qian, H.W.
登録日2018-06-04
公開日2018-07-11
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献Structural basis for the recognition of Sonic Hedgehog by human Patched1.
Science, 361, 2018
6DMY
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BU of 6dmy by Molmil
Cryo-EM structure of human Ptch1 and ShhN complex
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
著者Yan, N, Gong, X, Qian, H.W.
登録日2018-06-05
公開日2018-07-11
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献Structural basis for the recognition of Sonic Hedgehog by human Patched1.
Science, 361, 2018
6DMO
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BU of 6dmo by Molmil
Cryo-EM structure of human Ptch1 with three mutations L282Q/T500F/P504L
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Protein patched homolog 1
著者Yan, N, Gong, X, Qian, H.W.
登録日2018-06-05
公開日2018-07-11
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (4.1 Å)
主引用文献Structural basis for the recognition of Sonic Hedgehog by human Patched1.
Science, 361, 2018
6DS5
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BU of 6ds5 by Molmil
Cryo EM structure of human SEIPIN
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Seipin
著者Yan, R.H, Qian, H.W, Yan, N, Yang, H.Y.
登録日2018-06-13
公開日2018-10-24
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献Human SEIPIN Binds Anionic Phospholipids.
Dev. Cell, 47, 2018
6N7H
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BU of 6n7h by Molmil
Cryo-EM structure of the 2:1 hPtch1-Shhp complex
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
著者Yan, N, Gong, X, Qian, H.W.
登録日2018-11-27
公開日2019-05-29
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献Inhibition of tetrameric Patched1 by Sonic Hedgehog through an asymmetric paradigm.
Nat Commun, 10, 2019
6N7G
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BU of 6n7g by Molmil
Cryo-EM structure of tetrameric Ptch1 in complex with ShhNp (form I)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
著者Yan, N, Gong, X, Qian, H.W.
登録日2018-11-27
公開日2019-05-29
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (6.8 Å)
主引用文献Inhibition of tetrameric Patched1 by Sonic Hedgehog through an asymmetric paradigm.
Nat Commun, 10, 2019
6N7K
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BU of 6n7k by Molmil
Cryo-EM structure of tetrameric Ptch1 in complex with ShhNp (form II)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
著者Yan, N, Gong, X, Qian, H.W.
登録日2018-11-27
公開日2019-05-29
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (6.5 Å)
主引用文献Inhibition of tetrameric Patched1 by Sonic Hedgehog through an asymmetric paradigm.
Nat Commun, 10, 2019

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