6ZQK
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![BU of 6zqk by Molmil](/molmil-images/mine/6zqk) | HER2-binding scFv-Fab fusion 841 | Descriptor: | 1,2-ETHANEDIOL, 841 heavy chain, 841 light chain | Authors: | Kast, F, Schwill, M, Stueber, J.C, Pfundstein, S, Nagy-Davidescu, G, Monne Rodriguez, J.M, Seehusen, F, Richter, C.P, Honegger, A, Hartmann, K.P, Weber, T.G, Kroener, F, Ernst, P, Piehler, J, Plueckthun, A. | Deposit date: | 2020-07-09 | Release date: | 2021-06-30 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Engineering an anti-HER2 biparatopic antibody with a multimodal mechanism of action. Nat Commun, 12, 2021
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1FG2
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![BU of 1fg2 by Molmil](/molmil-images/mine/1fg2) | CRYSTAL STRUCTURE OF THE LCMV PEPTIDIC EPITOPE GP33 IN COMPLEX WITH THE MURINE CLASS I MHC MOLECULE H-2DB | Descriptor: | BETA-2 MICROGLOBULIN, H-2 CLASS I HISTOCOMPATIBILITY ANTIGEN, D-B ALPHA CHAIN, ... | Authors: | Tissot, A.C, Ciatto, C, Mittl, P.R.E, Gruetter, M.G, Plueckthun, A. | Deposit date: | 2000-07-27 | Release date: | 2000-10-04 | Last modified: | 2022-12-21 | Method: | X-RAY DIFFRACTION (2.754 Å) | Cite: | Viral escape at the molecular level explained by quantitative T-cell receptor/peptide/MHC interactions and the crystal structure of a peptide/MHC complex. J.Mol.Biol., 302, 2000
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1TD0
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![BU of 1td0 by Molmil](/molmil-images/mine/1td0) | Viral capsid protein SHP at pH 5.5 | Descriptor: | Head decoration protein | Authors: | Chang, C, Forrer, P, Ott, D, Wlodawer, A, Plueckthun, A. | Deposit date: | 2004-05-21 | Release date: | 2004-11-02 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Kinetic Stability and Crystal Structure of the Viral Capsid Protein SHP J.Mol.Biol., 344, 2004
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1SVX
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![BU of 1svx by Molmil](/molmil-images/mine/1svx) | Crystal structure of a designed selected Ankyrin Repeat protein in complex with the Maltose Binding Protein | Descriptor: | Ankyrin Repeat Protein off7, Maltose-binding periplasmic protein | Authors: | Binz, H.K, Amstutz, P, Kohl, A, Stumpp, M.T, Briand, C, Forrer, P, Gruetter, M.G, Plueckthun, A. | Deposit date: | 2004-03-30 | Release date: | 2004-05-25 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.24 Å) | Cite: | High-affinity binders selected from designed ankyrin repeat protein libraries NAT.BIOTECHNOL., 22, 2004
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1TD4
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![BU of 1td4 by Molmil](/molmil-images/mine/1td4) | Crystal structure of VSHP_BPP21 in space group H3 with high resolution. | Descriptor: | Head decoration protein | Authors: | Chang, C, Forrer, P, Ott, D, Wlodawer, A, Plueckthun, A. | Deposit date: | 2004-05-21 | Release date: | 2004-11-02 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Kinetic Stability and Crystal Structure of the Viral Capsid Protein SHP. J.Mol.Biol., 344, 2004
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1TD3
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![BU of 1td3 by Molmil](/molmil-images/mine/1td3) | Crystal structure of VSHP_BPP21 in space group C2 | Descriptor: | Head decoration protein | Authors: | Chang, C, Forrer, P, Ott, D, Wlodawer, A, Plueckthun, A. | Deposit date: | 2004-05-21 | Release date: | 2004-11-02 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.37 Å) | Cite: | Kinetic Stability and Crystal Structure of the Viral Capsid Protein SHP. J.Mol.Biol., 344, 2004
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1TCZ
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![BU of 1tcz by Molmil](/molmil-images/mine/1tcz) | |
4PLR
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![BU of 4plr by Molmil](/molmil-images/mine/4plr) | Crystal Structures of Designed Armadillo Repeat Proteins: Implications of Construct Design and Crystallization Conditions on Overall Structure. | Descriptor: | Arm00008, CALCIUM ION | Authors: | Reichen, C, Madhurantakam, C, Plueckthun, A, Mittl, P. | Deposit date: | 2014-05-19 | Release date: | 2014-08-27 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structures of designed armadillo repeat proteins: Implications of construct design and crystallization conditions on overall structure. Protein Sci., 23, 2014
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4PLS
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![BU of 4pls by Molmil](/molmil-images/mine/4pls) | Crystal Structures of Designed Armadillo Repeat Proteins: Implications of Construct Design and Crystallization Conditions on Overall Structure. | Descriptor: | ACETATE ION, Arm00010, CALCIUM ION | Authors: | Reichen, C, Madhurantakam, C, Plueckthun, A, Mittl, P.R. | Deposit date: | 2014-05-19 | Release date: | 2014-12-10 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Crystal Structures of Designed Armadillo Repeat Proteins: Implications of Construct Design and Crystallization Conditions on Overall Structure. Protein Sci., 23, 2014
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1KP5
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![BU of 1kp5 by Molmil](/molmil-images/mine/1kp5) | Cyclic Green Fluorescent Protein | Descriptor: | Green Fluorescent Protein, SULFATE ION | Authors: | Hofmann, A, Iwai, H, Plueckthun, A, Wlodawer, A. | Deposit date: | 2001-12-28 | Release date: | 2002-08-28 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structure of cyclized green fluorescent protein. Acta Crystallogr.,Sect.D, 58, 2002
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7DNF
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![BU of 7dnf by Molmil](/molmil-images/mine/7dnf) | DARPin 63_B7 in complex with V3-IY (MN) crown mimetic | Descriptor: | DARPin 63_B7, SULFATE ION, V3-IY (MN) crown mimetic peptide | Authors: | Wu, Y, Plueckthun, A. | Deposit date: | 2020-12-09 | Release date: | 2021-12-15 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.78 Å) | Cite: | Distinct conformations of the HIV-1 V3 loop crown are targetable for broad neutralization. Nat Commun, 12, 2021
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7DNG
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![BU of 7dng by Molmil](/molmil-images/mine/7dng) | |
2RU4
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![BU of 2ru4 by Molmil](/molmil-images/mine/2ru4) | Designed Armadillo Repeat Protein Self-ASsembled Complex (YIIM2-MAII) | Descriptor: | Armadillo Repeat Protein, C-terminal fragment, MAII, ... | Authors: | Zerbe, O, Christen, M.T, Plueckthun, A, Watson, R.P. | Deposit date: | 2013-11-22 | Release date: | 2014-07-23 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Spontaneous self-assembly of engineered armadillo repeat protein fragments into a folded structure Structure, 22, 2014
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6FES
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![BU of 6fes by Molmil](/molmil-images/mine/6fes) | Crystal structure of novel repeat protein BRIC2 fused to DARPin D12 | Descriptor: | 1,2-ETHANEDIOL, D12_BRIC2, a synthetic protein,D12_BRIC2, ... | Authors: | ElGamacy, M, Coles, M, Ernst, P, Zhu, H, Hartmann, M.D, Plueckthun, A, Lupas, A. | Deposit date: | 2018-01-03 | Release date: | 2018-09-05 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | An Interface-Driven Design Strategy Yields a Novel, Corrugated Protein Architecture. ACS Synth Biol, 7, 2018
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6FF6
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![BU of 6ff6 by Molmil](/molmil-images/mine/6ff6) | Crystal structure of novel repeat protein BRIC1 | Descriptor: | BRIC1 | Authors: | ElGamacy, M, Coles, M, Ernst, P, Zhu, H, Hartmann, M.D, Plueckthun, A, Lupas, A.N. | Deposit date: | 2018-01-03 | Release date: | 2018-09-05 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | An Interface-Driven Design Strategy Yields a Novel, Corrugated Protein Architecture. ACS Synth Biol, 7, 2018
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2RU5
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![BU of 2ru5 by Molmil](/molmil-images/mine/2ru5) | |
6EQC
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![BU of 6eqc by Molmil](/molmil-images/mine/6eqc) | Cryo-EM reconstruction of a complex of a binding protein and human adenovirus C5 hexon | Descriptor: | Hexon protein, scFv of 9C12 antibody | Authors: | Schmid, M, Ernst, P, Honegger, A, Suomalainen, M, Zimmermann, M, Braun, L, Stauffer, S, Thom, C, Dreier, B, Eibauer, M, Kipar, A, Vogel, V, Greber, U.F, Medalia, O, Plueckthun, A. | Deposit date: | 2017-10-12 | Release date: | 2018-02-07 | Last modified: | 2018-02-14 | Method: | ELECTRON MICROSCOPY (7.4 Å) | Cite: | Adenoviral vector with shield and adapter increases tumor specificity and escapes liver and immune control. Nat Commun, 9, 2018
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4K5A
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![BU of 4k5a by Molmil](/molmil-images/mine/4k5a) | Co-crystallization with conformation-specific designed ankyrin repeat proteins explains the conformational flexibility of BCL-W | Descriptor: | Bcl-2-like protein 2, Designed Ankyrin Repeat Protein 013_D12 | Authors: | Schilling, J, Schoeppe, J, Sauer, E, Plueckthun, A. | Deposit date: | 2013-04-14 | Release date: | 2014-04-16 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Co-Crystallization with Conformation-Specific Designed Ankyrin Repeat Proteins Explains the Conformational Flexibility of BCL-W J.Mol.Biol., 426, 2014
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4K5B
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![BU of 4k5b by Molmil](/molmil-images/mine/4k5b) | Co-crystallization with conformation-specific designed ankyrin repeat proteins explains the conformational flexibility of BCL-W | Descriptor: | Apoptosis regulator BCL-W, Bcl-2-like protein 2 | Authors: | Schilling, J, Schoeppe, J, Sauer, E, Plueckthun, A. | Deposit date: | 2013-04-14 | Release date: | 2014-04-16 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Co-Crystallization with Conformation-Specific Designed Ankyrin Repeat Proteins Explains the Conformational Flexibility of BCL-W J.Mol.Biol., 426, 2014
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6YVR
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![BU of 6yvr by Molmil](/molmil-images/mine/6yvr) | Crystal structure of the neurotensin receptor 1 in complex with the peptide full agonist NTS8-13 | Descriptor: | Neurotensin receptor type 1,Neurotensin receptor type 1,DARPin crystallisation chaperone, neurotensin NTS8-13 (full agonist), nonyl beta-D-glucopyranoside | Authors: | Deluigi, M, Merklinger, L, Hilge, M, Ernst, P, Klipp, A, Klenk, C, Plueckthun, A. | Deposit date: | 2020-04-28 | Release date: | 2021-02-10 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.458 Å) | Cite: | Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism. Sci Adv, 7, 2021
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6Z4Q
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![BU of 6z4q by Molmil](/molmil-images/mine/6z4q) | Crystal structure of the neurotensin receptor 1 in complex with the small-molecule inverse agonist SR142948A | Descriptor: | 2-[[5-(2,6-dimethoxyphenyl)-1-[4-[3-(dimethylamino)propyl-methyl-carbamoyl]-2-propan-2-yl-phenyl]pyrazol-3-yl]carbonylamino]adamantane-2-carboxylic acid, Neurotensin receptor type 1,Neurotensin receptor type 1,DARPin | Authors: | Deluigi, M, Klipp, A, Hilge, M, Merklinger, L, Klenk, C, Plueckthun, A. | Deposit date: | 2020-05-25 | Release date: | 2021-02-10 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.923 Å) | Cite: | Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism. Sci Adv, 7, 2021
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6ZIN
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![BU of 6zin by Molmil](/molmil-images/mine/6zin) | Crystal structure of the neurotensin receptor 1 in complex with the small molecule inverse agonist SR48692 | Descriptor: | 2-[[1-(7-chloranylquinolin-4-yl)-5-(2,6-dimethoxyphenyl)pyrazol-3-yl]carbonylamino]adamantane-2-carboxylic acid, Neurotensin receptor type 1,DARPin,HRV 3C protease recognition sequence | Authors: | Deluigi, M, Klipp, A, Hilge, M, Merklinger, L, Klenk, C, Plueckthun, A. | Deposit date: | 2020-06-26 | Release date: | 2021-02-10 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.639 Å) | Cite: | Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism. Sci Adv, 7, 2021
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6Z8N
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![BU of 6z8n by Molmil](/molmil-images/mine/6z8n) | Crystal structure of the neurotensin receptor 1 in complex with the small-molecule full agonist SRI-9829 | Descriptor: | (2~{S})-4-methyl-2-[(1-quinolin-8-ylsulfonylindol-3-yl)carbonylamino]pentanoic acid, Neurotensin receptor type 1,Neurotensin receptor type 1,Neurotensin receptor type 1,Neurotensin receptor type 1,Neurotensin receptor 1 (NTSR1),Neurotensin receptor 1 (NTSR1) | Authors: | Deluigi, M, Klipp, A, Hilge, M, Merklinger, L, Klenk, C, Plueckthun, A. | Deposit date: | 2020-06-02 | Release date: | 2021-02-10 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.803 Å) | Cite: | Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism. Sci Adv, 7, 2021
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6Z4S
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![BU of 6z4s by Molmil](/molmil-images/mine/6z4s) | Crystal structure of the neurotensin receptor 1 (NTSR1-H4bmx) in complex with the small molecule inverse agonist SR48692 | Descriptor: | 2-[[1-(7-chloranylquinolin-4-yl)-5-(2,6-dimethoxyphenyl)pyrazol-3-yl]carbonylamino]adamantane-2-carboxylic acid, Neurotensin receptor type 1,DARPin,HRV 3C protease recognition sequence | Authors: | Deluigi, M, Klipp, A, Hilge, M, Merklinger, L, Klenk, C, Plueckthun, A. | Deposit date: | 2020-05-25 | Release date: | 2021-02-10 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.707 Å) | Cite: | Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism. Sci Adv, 7, 2021
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6Z66
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![BU of 6z66 by Molmil](/molmil-images/mine/6z66) | Crystal structure of apo-state neurotensin receptor 1 | Descriptor: | Neurotensin receptor type 1,Neurotensin receptor type 1,DARPin | Authors: | Deluigi, M, Klipp, A, Hilge, M, Merklinger, L, Klenk, C, Plueckthun, A. | Deposit date: | 2020-05-27 | Release date: | 2021-02-10 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (3.192 Å) | Cite: | Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism. Sci Adv, 7, 2021
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