Loading
PDBj
English日本語简体中文繁體中文한국어
✖
ﾒﾆｭｰPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
PDB: 72 件
4OZG
DownloadVisualize
BU of 4ozg by Molmil
D2 protein complex
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
著者Petersen, J, Reid, H.H, Rossjohn, J.
登録日2014-02-16
公開日2014-04-16
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献T-cell receptor recognition of HLA-DQ2-gliadin complexes associated with celiac disease.
Nat.Struct.Mol.Biol., 21, 2014
6FTN
DownloadVisualize
BU of 6ftn by Molmil
mPI3Kd IN COMPLEX WITH AZ2
分子名称: Phosphor inositol 3 kinase, ~{N}-[5-[2-[(1~{S})-1-cyclopropylethyl]-7-methyl-1-oxidanylidene-3~{H}-isoindol-5-yl]-4-methyl-1,3-thiazol-2-yl]ethanamide
著者Petersen, J.
登録日2018-02-22
公開日2018-06-20
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Discovery of Highly Isoform Selective Orally Bioavailable Phosphoinositide 3-Kinase (PI3K)-gamma Inhibitors.
J. Med. Chem., 61, 2018
5V4N
DownloadVisualize
BU of 5v4n by Molmil
Structure of HLA-DR1 with bound alpha3(135-145) peptide
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, HLA-DRA1, alpha3(135-145)-HLA-DRB1*01:01
著者Petersen, J, Rossjohn, J.
登録日2017-03-10
公開日2017-05-03
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.405 Å)
主引用文献Dominant protection from HLA-linked autoimmunity by antigen-specific regulatory T cells.
Nature, 545, 2017
3FQW
DownloadVisualize
BU of 3fqw by Molmil
Phosphorylation of self-peptides alters Human Leukocyte Antigen Class I-restricted antigen presentation and generates tumor specific epitopes
分子名称: Beta-2-microglobulin, CADMIUM ION, COBALT (II) ION, ...
著者Petersen, J, Rossjohn, J.
登録日2009-01-07
公開日2009-03-03
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.927 Å)
主引用文献Phosphorylated self-peptides alter human leukocyte antigen class I-restricted antigen presentation and generate tumor-specific epitopes
Proc.Natl.Acad.Sci.Usa, 106, 2009
3FQT
DownloadVisualize
BU of 3fqt by Molmil
Phosphorylation of self-peptides alters Human Leukocyte Antigen Class I-restricted antigen presentation and generates tumor specific epitopes
分子名称: Beta-2-microglobulin, CADMIUM ION, GLYCEROL, ...
著者Petersen, J, Rossjohn, J.
登録日2009-01-07
公開日2009-03-03
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Phosphorylated self-peptides alter human leukocyte antigen class I-restricted antigen presentation and generate tumor-specific epitopes
Proc.Natl.Acad.Sci.Usa, 106, 2009
3FQR
DownloadVisualize
BU of 3fqr by Molmil
Phosphorylation of self-peptides alters Human Leukocyte Antigen Class I-restricted antigen presentation and generates tumor specific epitopes
分子名称: Beta-2-microglobulin, CADMIUM ION, GLYCEROL, ...
著者Petersen, J, Rossjohn, J.
登録日2009-01-07
公開日2009-03-03
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Phosphorylated self-peptides alter human leukocyte antigen class I-restricted antigen presentation and generate tumor-specific epitopes
Proc.Natl.Acad.Sci.Usa, 106, 2009
3FQU
DownloadVisualize
BU of 3fqu by Molmil
Phosphorylation of self-peptides alters Human Leukocyte Antigen Class I-restricted antigen presentation and generates tumor specific epitopes
分子名称: Beta-2-microglobulin, CADMIUM ION, GLYCEROL, ...
著者Petersen, J, Rossjohn, J.
登録日2009-01-07
公開日2009-03-03
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Phosphorylated self-peptides alter human leukocyte antigen class I-restricted antigen presentation and generate tumor-specific epitopes
Proc.Natl.Acad.Sci.Usa, 106, 2009
3FQN
DownloadVisualize
BU of 3fqn by Molmil
Phosphorylation of self-peptides alters Human Leukocyte Antigen Class I-restricted antigen presentation and generates tumor specific epitopes
分子名称: Beta-2-microglobulin, CADMIUM ION, GLYCEROL, ...
著者Petersen, J, Rossjohn, J.
登録日2009-01-07
公開日2009-03-03
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Phosphorylated self-peptides alter human leukocyte antigen class I-restricted antigen presentation and generate tumor-specific epitopes
Proc.Natl.Acad.Sci.Usa, 106, 2009
3FQX
DownloadVisualize
BU of 3fqx by Molmil
Phosphorylation of self-peptides alters Human Leukocyte Antigen Class I-restricted antigen presentation and generates tumor specific epitopes
分子名称: Beta-2-microglobulin, CADMIUM ION, GLYCEROL, ...
著者Petersen, J, Rossjohn, J.
登録日2009-01-07
公開日2009-03-03
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Phosphorylated self-peptides alter human leukocyte antigen class I-restricted antigen presentation and generate tumor-specific epitopes
Proc.Natl.Acad.Sci.Usa, 106, 2009
5V4M
DownloadVisualize
BU of 5v4m by Molmil
Structure of HLA-DR15 with bound alpha3(135-145) peptide
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, HLA-DRA1, ...
著者Petersen, J, Rossjohn, J.
登録日2017-03-10
公開日2017-05-03
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Dominant protection from HLA-linked autoimmunity by antigen-specific regulatory T cells.
Nature, 545, 2017
6GY0
DownloadVisualize
BU of 6gy0 by Molmil
mPI3Kd IN COMPLEX WITH AZ3
分子名称: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, ~{N}-[4-methyl-5-(1-oxidanylidene-7-sulfamoyl-isoindol-5-yl)-1,3-thiazol-2-yl]ethanamide
著者Petersen, J.
登録日2018-06-27
公開日2019-02-06
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献A class of highly selective inhibitors bind to an active state of PI3K gamma.
Nat.Chem.Biol., 15, 2019
5T27
DownloadVisualize
BU of 5t27 by Molmil
mPI3Kd IN COMPLEX WITH 5d
分子名称: 3-(benzotriazol-1-yl)-5-[1-methyl-5-[(1~{S})-1-morpholin-4-ylethyl]-1,2,4-triazol-3-yl]pyrazin-2-amine, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
著者Petersen, J, Terstige, I, Perry, M, Svensson, T, Tyrchan, C, Lindmark, H, Oster, L.
登録日2016-08-23
公開日2017-04-19
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Discovery of triazole aminopyrazines as a highly potent and selective series of PI3K delta inhibitors.
Bioorg. Med. Chem. Lett., 27, 2017
5T23
DownloadVisualize
BU of 5t23 by Molmil
PI3Kg IN COMPLEX WITH 5d
分子名称: 3-(benzotriazol-1-yl)-5-[1-methyl-5-[(1~{S})-1-morpholin-4-ylethyl]-1,2,4-triazol-3-yl]pyrazin-2-amine, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
著者Petersen, J, Terstige, I, Perry, M, Svensson, T, Tyrchan, C, Lindmark, H, Oster, L.
登録日2016-08-23
公開日2017-04-19
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.78 Å)
主引用文献Discovery of triazole aminopyrazines as a highly potent and selective series of PI3K delta inhibitors.
Bioorg. Med. Chem. Lett., 27, 2017
5T2B
DownloadVisualize
BU of 5t2b by Molmil
mPI3Kd IN COMPLEX WITH 5e
分子名称: 5-[1-methyl-5-(1-phenylcyclopropyl)-1,2,4-triazol-3-yl]-3-(1~{H}-pyrazol-4-yl)pyrazin-2-amine, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
著者Petersen, J, Terstige, I, Perry, M, Svensson, T, Tyrchan, C, Lindmark, H, Oster, L.
登録日2016-08-23
公開日2017-04-19
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Discovery of triazole aminopyrazines as a highly potent and selective series of PI3K delta inhibitors.
Bioorg. Med. Chem. Lett., 27, 2017
5T2I
DownloadVisualize
BU of 5t2i by Molmil
mPI3Kd IN COMPLEX WITH 7k
分子名称: 1-[3-azanyl-6-[1-methyl-5-(1-phenylcyclopropyl)-1,2,4-triazol-3-yl]pyrazin-2-yl]pyrazole-4-carboxamide, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
著者Petersen, J, Terstige, I, Perry, M, Svensson, T, Tyrchan, C, Lindmark, H, Oster, L.
登録日2016-08-23
公開日2017-04-19
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Discovery of triazole aminopyrazines as a highly potent and selective series of PI3K delta inhibitors.
Bioorg. Med. Chem. Lett., 27, 2017
5T2D
DownloadVisualize
BU of 5t2d by Molmil
mPI3Kd IN COMPLEX WITH 7j
分子名称: 4-[3-azanyl-6-[1-methyl-5-(1-phenylcyclopropyl)-1,2,4-triazol-3-yl]pyrazin-2-yl]-~{N},~{N}-dimethyl-pyrazole-1-sulfonamide, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
著者Petersen, J, Terstige, I, Perry, M, Svensson, T, Tyrchan, C, Lindmark, H, Oster, L.
登録日2016-08-23
公開日2017-04-19
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Discovery of triazole aminopyrazines as a highly potent and selective series of PI3K delta inhibitors.
Bioorg. Med. Chem. Lett., 27, 2017
5T2M
DownloadVisualize
BU of 5t2m by Molmil
mPI3Kd IN COMPLEX WITH 7m
分子名称: 4-[3-azanyl-6-[1-methyl-5-(1-phenylcyclopropyl)-1,2,4-triazol-3-yl]pyrazin-2-yl]benzamide, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
著者Petersen, J, Terstige, I, Perry, M, Svensson, T, Tyrchan, C, Lindmark, H, Oster, L.
登録日2016-08-23
公開日2017-04-19
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Discovery of triazole aminopyrazines as a highly potent and selective series of PI3K delta inhibitors.
Bioorg. Med. Chem. Lett., 27, 2017
5T2G
DownloadVisualize
BU of 5t2g by Molmil
mPI3Kd IN COMPLEX WITH 7i
分子名称: 4-[3-azanyl-6-[1-methyl-5-(1-phenylcyclopropyl)-1,2,4-triazol-3-yl]pyrazin-2-yl]pyrazole-1-carboxamide, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
著者Petersen, J, Terstige, I, Perry, M, Svensson, T, Tyrchan, C, Lindmark, H, Oster, L.
登録日2016-08-23
公開日2017-04-19
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Discovery of triazole aminopyrazines as a highly potent and selective series of PI3K delta inhibitors.
Bioorg. Med. Chem. Lett., 27, 2017
5T28
DownloadVisualize
BU of 5t28 by Molmil
mPI3Kd IN COMPLEX WITH 5k
分子名称: 3-(benzotriazol-1-yl)-5-[1-methyl-5-(1-phenylcyclopropyl)-1,2,4-triazol-3-yl]pyrazin-2-amine, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
著者Petersen, J, Terstige, I, Perry, M, Svensson, T, Tyrchan, C, Lindmark, H, Oster, L.
登録日2016-08-23
公開日2017-04-12
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Discovery of triazole aminopyrazines as a highly potent and selective series of PI3K delta inhibitors.
Bioorg. Med. Chem. Lett., 27, 2017
5T2L
DownloadVisualize
BU of 5t2l by Molmil
mPI3Kd IN COMPLEX WITH 7l
分子名称: 1-[3-azanyl-6-[1-methyl-5-(1-phenylcyclopropyl)-1,2,4-triazol-3-yl]pyrazin-2-yl]pyrazole-3-carboxamide, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
著者Petersen, J, Terstige, I, Perry, M, Svensson, T, Tyrchan, C, Lindmark, H, Oster, L.
登録日2016-08-23
公開日2017-04-19
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Discovery of triazole aminopyrazines as a highly potent and selective series of PI3K delta inhibitors.
Bioorg. Med. Chem. Lett., 27, 2017
6FH5
DownloadVisualize
BU of 6fh5 by Molmil
PI3Kg IN COMPLEX WITH Compound 7
分子名称: 3-methyl-1-(oxan-4-yl)-8-pyridin-3-yl-imidazo[4,5-c]quinolin-2-one, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
著者Petersen, J, Barlaam, B.
登録日2018-01-12
公開日2019-01-30
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (2.84 Å)
主引用文献Discovery and Optimisation of a Novel Series of 3-Cinnoline Carboxamides as Orally Bioavailable, Highly Potent and Selective Ataxia Telangiectasia Mutated (ATM) inhibitors
To Be Published
6GQ7
DownloadVisualize
BU of 6gq7 by Molmil
PI3Kg IN COMPLEX WITH INH
分子名称: 3-methyl-1-(oxan-4-yl)-8-pyridin-3-yl-imidazo[4,5-c]quinolin-2-one, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
著者Petersen, J.
登録日2018-06-07
公開日2018-06-20
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (2.84 Å)
主引用文献PI3Kg IN COMPLEX WITH INH
To Be Published
2XYA
DownloadVisualize
BU of 2xya by Molmil
Non-covalent inhibtors of rhinovirus 3C protease.
分子名称: 2-PHENYLQUINOLIN-4-OL, PICORNAIN 3C
著者Petersen, J, Edman, K, Edfeldt, F, Johansson, C.
登録日2010-11-16
公開日2011-04-27
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Non-Covalent Inhibitors of Rhinovirus 3C Protease.
Bioorg.Med.Chem.Lett., 21, 2011
6S5K
DownloadVisualize
BU of 6s5k by Molmil
LXRbeta ligand binding domain in complex with small molecule inhibitors
分子名称: 3-(4-phenylbutylamino)-1,4-bis(phenylmethyl)pyrrole-2,5-dione, Oxysterols receptor LXR-beta
著者Petersen, J.
登録日2019-07-01
公開日2019-12-18
最終更新日2024-05-15
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structural analysis identifies an escape route from the adverse lipogenic effects of liver X receptor ligands.
Commun Biol, 2, 2019
6T3B
DownloadVisualize
BU of 6t3b by Molmil
Crystal structure of PI3Kgamma with a dihydropurinone inhibitor (compound 4)
分子名称: 2-[(4-methoxy-2-methyl-phenyl)amino]-7-methyl-9-(4-oxidanylcyclohexyl)purin-8-one, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
著者Petersen, J, Oster, L, Schimpl, M, Goldberg, F.W, Finlay, M.R.V, Ting, A.K.T, Beattie, D, Lamont, G.M, Fallan, C, Wrigley, G.L, Howard, M.R, Williamson, B, Davies, B.R, Cadogan, E.B, Ramos-Montoya, A, Dean, E.
登録日2019-10-10
公開日2020-01-01
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (3.01 Å)
主引用文献The Discovery of 7-Methyl-2-[(7-methyl[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino]-9-(tetrahydro-2H-pyran-4-yl)-7,9-dihydro-8H-purin-8-one (AZD7648), a Potent and Selective DNA-Dependent Protein Kinase (DNA-PK) Inhibitor.
J.Med.Chem., 63, 2020

222624

件を2024-07-17に公開中

PDB statisticsPDBj update infoContact PDBjnumon