5V4M

Structure of HLA-DR15 with bound alpha3(135-145) peptide

Summary for 5V4M

• Entry DOI: 10.2210/pdb5v4m/pdb
• Descriptor: HLA-DRA1, alpha3(135-145)-HLA-DRB1*15:01, alpha-L-fucopyranose-(1-3)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• Functional Keywords: hla-dr, immune complex, antigen presenation, immune system
• Biological source: Homo sapiens (Human); More
• Cellular location: Cell membrane; Single-pass type I membrane protein: P01903 P01911
• Total number of polymer chains: 8
• Total formula weight: 189016.73

Authors

Petersen, J.,Rossjohn, J. (deposition date: 2017-03-10, release date: 2017-05-03, Last modification date: 2020-07-29)

• Primary citation: Ooi, J.D.,Petersen, J.,Tan, Y.H.,Huynh, M.,Willett, Z.J.,Ramarathinam, S.H.,Eggenhuizen, P.J.,Loh, K.L.,Watson, K.A.,Gan, P.Y.,Alikhan, M.A.,Dudek, N.L.,Handel, A.,Hudson, B.G.,Fugger, L.,Power, D.A.,Holt, S.G.,Coates, P.T.,Gregersen, J.W.,Purcell, A.W.,Holdsworth, S.R.,La Gruta, N.L.,Reid, H.H.,Rossjohn, J.,Kitching, A.R.; Dominant protection from HLA-linked autoimmunity by antigen-specific regulatory T cells.; Nature, 545:243-247, 2017; PubMed: 28467828; DOI: 10.1038/nature22329

Experimental method

X-RAY DIFFRACTION (2.1 Å)