6GY0

mPI3Kd IN COMPLEX WITH AZ3

Summary for 6GY0

Entry DOI	10.2210/pdb6gy0/pdb
Descriptor	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, ~{N}-[4-methyl-5-(1-oxidanylidene-7-sulfamoyl-isoindol-5-yl)-1,3-thiazol-2-yl]ethanamide (3 entities in total)
Functional Keywords	inhibitor, pi3k, transferase
Biological source	Mus musculus (Mouse)
Total number of polymer chains	1
Total formula weight	108002.88
Authors	Petersen, J. (deposition date: 2018-06-27, release date: 2019-02-06, Last modification date: 2024-05-01)
Primary citation	Gangadhara, G.,Dahl, G.,Bohnacker, T.,Rae, R.,Gunnarsson, J.,Blaho, S.,Oster, L.,Lindmark, H.,Karabelas, K.,Pemberton, N.,Tyrchan, C.,Mogemark, M.,Wymann, M.P.,Williams, R.L.,Perry, M.W.D.,Papavoine, T.,Petersen, J. A class of highly selective inhibitors bind to an active state of PI3K gamma. Nat.Chem.Biol., 15:348-357, 2019 Cited by PubMed: 30718815 DOI: 10.1038/s41589-018-0215-0 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.55 Å)

Structure validation