6FH5
PI3Kg IN COMPLEX WITH Compound 7
Summary for 6FH5
Entry DOI | 10.2210/pdb6fh5/pdb |
Descriptor | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, 3-methyl-1-(oxan-4-yl)-8-pyridin-3-yl-imidazo[4,5-c]quinolin-2-one (3 entities in total) |
Functional Keywords | kinase, inhibitor, complex, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 111087.51 |
Authors | Petersen, J.,Barlaam, B. (deposition date: 2018-01-12, release date: 2019-01-30, Last modification date: 2024-05-01) |
Primary citation | Barlaam, B.,Cadogan, E.,Cambell, A.,Colclough, N.,Dishington, A.,Durant, S.,Goldberg, K.,Hassall, L.A.,Hughes, G.D.,MacFaul, P.A.,McGuire, T.M.,Pass, M.,Patel, A.,Pearson, S.,Petersen, J.,Pike, K.G.,Robb, G.,Stratton, N.,Xin, N.,Zhai, B. Discovery and Optimisation of a Novel Series of 3-Cinnoline Carboxamides as Orally Bioavailable, Highly Potent and Selective Ataxia Telangiectasia Mutated (ATM) inhibitors To Be Published, |
Experimental method | X-RAY DIFFRACTION (2.84 Å) |
Structure validation
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