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PDB: 151 件
2WER
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Yeast Hsp90 N-terminal domain LI-IV mutant with Radicicol
分子名称: ATP-DEPENDENT MOLECULAR CHAPERONE HSP82, RADICICOL
著者Roe, S.M, Prodromou, C, Pearl, L.H.
登録日2009-04-01
公開日2009-04-14
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structural Basis of the Radicicol Resistance Displayed by a Fungal Hsp90.
Acs Chem.Biol., 4, 2009
2W2X
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Complex of Rac2 and PLCg2 spPH Domain
分子名称: 1-PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, MAGNESIUM ION, ...
著者Opaleye, O, Bunney, T.D, Roe, S.M, Pearl, L.H.
登録日2008-11-04
公開日2009-05-05
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural Insights Into Formation of an Active Signaling Complex between Rac and Phospholipase C Gamma 2.
Mol.Cell, 34, 2009
2VW5
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Structure Of The Hsp90 Inhibitor 7-O-carbamoylpremacbecin Bound To The N- Terminus Of Yeast Hsp90
分子名称: (4E,8S,9R,10E,12S,13R,14S,16R)-13,20-dihydroxy-14-methoxy-4,8,10,12,16-pentamethyl-3-oxo-2-azabicyclo[16.3.1]docosa-1(22),4,10,18,20-pentaen-9-yl carbamate, ATP-DEPENDENT MOLECULAR CHAPERONE HSP82, SULFATE ION
著者Roe, S.M, Prodromou, C, Pearl, L.H.
登録日2008-06-16
公開日2008-09-02
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Optimizing Natural Products by Biosynthetic Engineering: Discovery of Nonquinone Hsp90 Inhibitors.
J.Med.Chem., 51, 2008
2W3O
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Crystal structure of the human PNKP FHA domain in complex with an XRCC1-derived phosphopeptide
分子名称: BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE/KINASE, CALCIUM ION, DNA REPAIR PROTEIN XRCC1
著者Oliver, A.W, Ali, A.A.E, Pearl, L.H.
登録日2008-11-13
公開日2009-02-03
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Specific Recognition of a Multiply Phosphorylated Motif in the DNA Repair Scaffold Xrcc1 by the Fha Domain of Human Pnk.
Nucleic Acids Res., 37, 2009
2VWC
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STRUCTURE OF THE HSP90 INHIBITOR MACBECIN BOUND TO THE N-TERMINUS OF YEAST HSP90.
分子名称: ATP-DEPENDENT MOLECULAR CHAPERONE HSP82, GLYCEROL, MACBECIN
著者Roe, S.M, Prodromou, C, Pearl, L.H.
登録日2008-06-20
公開日2008-07-01
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Molecular Characterisation of Macbecin as an Hsp90 Inhibitor
J.Med.Chem., 51, 2008
2W2W
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PLCg2 Split Pleckstrin Homology (PH) Domain
分子名称: 1-PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
著者Opaleye, O, Bunney, T.D, Roe, S.M, Pearl, L.H.
登録日2008-11-04
公開日2009-05-05
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structural Insights Into Formation of an Active Signaling Complex between Rac and Phospholipase C Gamma 2.
Mol.Cell, 34, 2009
2W2T
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Rac2 (G12V) in complex with GDP
分子名称: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
著者Opaleye, O, Bunney, T.D, Roe, S.M, Pearl, L.H.
登録日2008-11-04
公開日2009-05-05
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Structural Insights Into Formation of an Active Signaling Complex between Rac and Phospholipase C Gamma 2.
Mol.Cell, 34, 2009
2WEQ
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Yeast Hsp90 N-terminal domain LI-IV mutant with Geldanamycin
分子名称: ATP-DEPENDENT MOLECULAR CHAPERONE HSP82, GELDANAMYCIN, GLYCEROL
著者Roe, S.M, Prodromou, C, Pearl, L.H.
登録日2009-04-01
公開日2009-04-14
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural Basis of the Radicicol Resistance Displayed by a Fungal Hsp90
Acs Chem.Biol., 4, 2009
2W2V
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Rac2 (G12V) in complex with GTPgS
分子名称: GUANOSINE-5'-TRIPHOSPHATE, RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
著者Opaleye, O, Bunney, T.D, Roe, S.M, Pearl, L.H.
登録日2008-11-04
公開日2009-05-05
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural Insights Into Formation of an Active Signaling Complex between Rac and Phospholipase C Gamma 2.
Mol.Cell, 34, 2009
2WEP
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Yeast Hsp90 N-terminal domain LI-IV mutant with ADP
分子名称: ADENOSINE-5'-DIPHOSPHATE, ATP-DEPENDENT MOLECULAR CHAPERONE HSP82
著者Roe, S.M, Prodromou, C, Pearl, L.H.
登録日2009-04-01
公開日2009-04-14
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural Basis of the Radicicol Resistance Displayed by a Fungal Hsp90.
Acs Chem.Biol., 4, 2009
2W18
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Crystal structure of the C-terminal WD40 domain of human PALB2
分子名称: GLYCEROL, PARTNER AND LOCALIZER OF BRCA2
著者Oliver, A.W, Pearl, L.H.
登録日2008-10-15
公開日2009-07-28
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural Basis for Recruitment of Brca2 by Palb2
Embo Rep., 10, 2009
2V74
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Crystal structure of coactivator-associated arginine methyltransferase 1 (CARM1), in complex with S-adenosyl-homocysteine
分子名称: HISTONE-ARGININE METHYLTRANSFERASE CARM1, S-ADENOSYL-L-HOMOCYSTEINE
著者Yue, W.W, Hassler, M, Roe, S.M, Thompson-Vale, V, Pearl, L.H.
登録日2007-07-26
公開日2007-10-02
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Insights Into Histone Code Syntax from Structural and Biochemical Studies of Carm1 Methyltransferase
Embo J., 26, 2007
2V7E
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Crystal structure of coactivator-associated arginine methyltransferase 1 (CARM1), unliganded
分子名称: HISTONE-ARGININE METHYLTRANSFERASE CARM1, MERCURY (II) ION
著者Yue, W.W, Hassler, M, Roe, S.M, Thompson-Vale, V, Pearl, L.H.
登録日2007-07-30
公開日2007-10-02
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Insights Into Histone Code Syntax from Structural and Biochemical Studies of Carm1 Methyltransferase
Embo J., 26, 2007
2VXB
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Structure of the Crb2-BRCT2 domain
分子名称: DNA REPAIR PROTEIN RHP9, PRASEODYMIUM ION
著者Kilkenny, M.L, Roe, S.M, Pearl, L.H.
登録日2008-07-03
公開日2008-08-12
最終更新日2019-05-15
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural and Functional Analysis of the Crb2-Brct2 Domain Reveals Distinct Roles in Checkpoint Signaling and DNA Damage Repair.
Genes Dev., 22, 2008
2WTI
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CRYSTAL STRUCTURE OF CHK2 IN COMPLEX WITH AN INHIBITOR
分子名称: 1,2-ETHANEDIOL, 4-[2-AMINO-5-(2,3-DIHYDROTHIENO[3,4-B][1,4]DIOXIN-5-YL)PYRIDIN-3-YL]BENZAMIDE, CHECKPOINT KINASE 2, ...
著者Hilton, S, Naud, S, Caldwell, J.J, Boxall, K, Burns, S, Anderson, V.E, Antoni, L, Allen, C.E, Pearl, L.H, Oliver, A.W, Aherne, G.W, Garrett, M.D, Collins, I.
登録日2009-09-16
公開日2009-12-29
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Identification and Characterisation of 2-Aminopyridine Inhibitors of Checkpoint Kinase 2
Bioorg.Med.Chem., 18, 2010
2WTD
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Crystal structure of Chk2 in complex with an inhibitor
分子名称: 1,2-ETHANEDIOL, 4-[2-AMINO-5-(1,3-BENZODIOXOL-4-YL)PYRIDIN-3-YL]BENZAMIDE, NITRATE ION, ...
著者Hilton, S, Naud, S, Caldwell, J.J, Boxall, K, Burns, S, Anderson, V.E, Antoni, L, Allen, C.E, Pearl, L.H, Oliver, A.W, Aherne, G.W, Garrett, M.D, Collins, I.
登録日2009-09-15
公開日2009-12-29
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Identification and Characterisation of 2-Aminopyridine Inhibitors of Checkpoint Kinase 2
Bioorg.Med.Chem., 18, 2010
2WTJ
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CRYSTAL STRUCTURE OF CHK2 IN COMPLEX WITH AN INHIBITOR
分子名称: 1,2-ETHANEDIOL, 2-AMINO-5-(2,3-DIHYDROTHIENO[3,4-B][1,4]DIOXIN-5-YL)-N-[2-(DIMETHYLAMINO)ETHYL]PYRIDINE-3-CARBOXAMIDE, CHECKPOINT KINASE 2, ...
著者Hilton, S, Naud, S, Caldwell, J.J, Boxall, K, Burns, S, Anderson, V.E, Antoni, L, Allen, C.E, Pearl, L.H, Oliver, A.W, Aherne, G.W, Garrett, M.D, Collins, I.
登録日2009-09-16
公開日2009-12-29
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Identification and Characterisation of 2-Aminopyridine Inhibitors of Checkpoint Kinase 2
Bioorg.Med.Chem., 18, 2010
1BB3
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HUMAN LYSOZYME MUTANT A96L
分子名称: LYSOZYME
著者Headley, A.G, Roe, S.M, Pearl, L.H.
登録日1998-04-28
公開日1998-08-12
最終更新日2023-08-02
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献

1BB4
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HUMAN LYSOZYME DOUBLE MUTANT A96L, W109H
分子名称: LYSOZYME
著者Headley, A.G, Roe, S.M, Pearl, L.H.
登録日1998-04-28
公開日1998-08-12
最終更新日2023-08-02
実験手法X-RAY DIFFRACTION (2.23 Å)
主引用文献

1BB5
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HUMAN LYSOZYME MUTANT A96L COMPLEXED WITH CHITOTRIOSE
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, LYSOZYME
著者Headley, A.G, Roe, S.M, Pearl, L.H.
登録日1998-04-28
公開日1998-08-12
最終更新日2023-08-02
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献

4AIF
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AIP TPR domain in complex with human Hsp90 peptide
分子名称: AH RECEPTOR-INTERACTING PROTEIN, HEAT SHOCK PROTEIN HSP 90-ALPHA, SULFATE ION
著者Morgan, R.M.L, Roe, S.M, Pearl, L.H, Prodromou, C.
登録日2012-02-09
公開日2013-01-23
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (2.006 Å)
主引用文献Structure of the Tpr Domain of Aip: Lack of Client Protein Interaction with the C-Terminal Alpha-7 Helix of the Tpr Domain of Aip is Sufficient for Pituitary Adenoma Predisposition.
Plos One, 7, 2012
4APO
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AIP TPR domain in complex with human Tomm20 peptide
分子名称: AH RECEPTOR-INTERACTING PROTEIN, DODECAETHYLENE GLYCOL, MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM20 HOMOLOG, ...
著者Morgan, R.M.L, Roe, S.M, Pearl, L.H, Prodromou, C.
登録日2012-04-04
公開日2013-01-23
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.895 Å)
主引用文献Structure of the Tpr Domain of Aip: Lack of Client Protein Interaction with the C-Terminal Alpha-7 Helix of the Tpr Domain of Aip is Sufficient for Pituitary Adenoma Predisposition.
Plos One, 7, 2012
2YI0
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Structural characterization of 5-Aryl-4-(5-substituted-2-4- dihydroxyphenyl)-1,2,3-thiadiazole Hsp90 inhibitors.
分子名称: 4-CHLORO-6-[5-(4-METHOXYPHENYL)-1,2,3-THIADIAZOL-4-YL]BENZENE-1,3-DIOL, HEAT SHOCK PROTEIN HSP 90-ALPHA, MAGNESIUM ION
著者Roe, S.M, Prodromou, C, Pearl, L.H.
登録日2011-05-10
公開日2012-05-16
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Co-Crystalization and in Vitro Biological Characterization of 5-Aryl-4-(5-Substituted-2-4-Dihydroxyphenyl)-1,2,3-Thiadiazole Hsp90 Inhibitors.
Plos One, 7, 2012
2YI7
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Structural characterization of 5-Aryl-4-(5-substituted-2-4- dihydroxyphenyl)-1,2,3-thiadiazole Hsp90 inhibitors.
分子名称: 4-CHLORO-6-[5-(4-ETHOXYPHENYL)-1,2,3-THIADIAZOL-4-YL BENZENE-1,3-DIOL, HEAT SHOCK PROTEIN HSP 90-ALPHA, MAGNESIUM ION
著者Roe, S.M, Prodromou, C, Pearl, L.H.
登録日2011-05-10
公開日2012-05-16
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Co-Crystalization and in Vitro Biological Characterization of 5-Aryl-4-(5-Substituted-2-4-Dihydroxyphenyl)-1,2,3-Thiadiazole Hsp90 Inhibitors.
Plos One, 7, 2012
2YI6
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Structural characterization of 5-Aryl-4-(5-substituted-2-4- dihydroxyphenyl)-1,2,3-thiadiazole Hsp90 inhibitors.
分子名称: 4-[5-(4-ETHOXYPHENYL)-1,2,3-THIADIAZOL-4-YL]-6-ETHYLBENZENE-1,3-DIOL, HEAT SHOCK PROTEIN HSP 90-ALPHA, MAGNESIUM ION
著者Roe, S.M, Prodromou, C, Pearl, L.H.
登録日2011-05-10
公開日2012-05-16
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Co-Crystalization and in Vitro Biological Characterization of 5-Aryl-4-(5-Substituted-2-4-Dihydroxyphenyl)-1,2,3-Thiadiazole Hsp90 Inhibitors.
Plos One, 7, 2012

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