4JT5
| mTORdeltaN-mLST8-pp242 complex | Descriptor: | 2-[4-amino-1-(propan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-1H-indol-5-ol, Serine/threonine-protein kinase mTOR, Target of rapamycin complex subunit LST8 | Authors: | Pavletich, N.P, Yang, H. | Deposit date: | 2013-03-22 | Release date: | 2013-05-08 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3.45 Å) | Cite: | mTOR kinase structure, mechanism and regulation. Nature, 497, 2013
|
|
4JSX
| structure of mTORDeltaN-mLST8-Torin2 complex | Descriptor: | 9-(6-aminopyridin-3-yl)-1-[3-(trifluoromethyl)phenyl]benzo[h][1,6]naphthyridin-2(1H)-one, Serine/threonine-protein kinase mTOR, Target of rapamycin complex subunit LST8 | Authors: | Pavletich, N.P, Yang, H. | Deposit date: | 2013-03-22 | Release date: | 2013-05-08 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | mTOR kinase structure, mechanism and regulation. Nature, 497, 2013
|
|
4RIA
| FAN1 Nuclease bound to 5' phosphorylated nicked DNA | Descriptor: | BARIUM ION, DNA (5'-D(*TP*TP*TP*TP*TP*TP*G*AP*GP*GP*CP*GP*TP*G)-3'), DNA (5'-D(P*AP*GP*AP*CP*TP*CP*CP*TP*C)-3'), ... | Authors: | Pavletich, N.P, Wang, R. | Deposit date: | 2014-10-05 | Release date: | 2014-12-10 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | DNA repair. Mechanism of DNA interstrand cross-link processing by repair nuclease FAN1. Science, 346, 2014
|
|
4RID
| Human FAN1 nuclease | Descriptor: | Fanconi-associated nuclease 1 | Authors: | Pavletich, N.P, Wang, R. | Deposit date: | 2014-10-05 | Release date: | 2014-12-03 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | DNA repair. Mechanism of DNA interstrand cross-link processing by repair nuclease FAN1. Science, 346, 2014
|
|
4RIC
| FAN1 Nuclease bound to 5' hydroxyl (dT-dT) single flap DNA | Descriptor: | CALCIUM ION, DNA (5'-D(*GP*CP*TP*GP*AP*GP*GP*AP*GP*TP*CP*T)-3'), DNA (5'-D(*TP*TP*AP*GP*CP*CP*AP*CP*GP*CP*CP*TP*AP*GP*AP*CP*TP*CP*CP*TP*C)-3'), ... | Authors: | Pavletich, N.P, Wang, R. | Deposit date: | 2014-10-05 | Release date: | 2014-12-03 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | DNA repair. Mechanism of DNA interstrand cross-link processing by repair nuclease FAN1. Science, 346, 2014
|
|
4RI9
| |
4RIB
| FAN1 Nuclease bound to 5' phosphorylated p(dT) single flap DNA | Descriptor: | CALCIUM ION, DNA (5'-D(*GP*CP*TP*GP*AP*GP*GP*AP*GP*TP*CP*T)-3'), DNA (5'-D(*TP*TP*TP*TP*TP*TP*GP*AP*GP*GP*CP*GP*TP*G)-3'), ... | Authors: | Pavletich, N.P, Wang, R. | Deposit date: | 2014-10-05 | Release date: | 2014-12-03 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3.25 Å) | Cite: | DNA repair. Mechanism of DNA interstrand cross-link processing by repair nuclease FAN1. Science, 346, 2014
|
|
4RI8
| |
1ZAA
| |
3CMX
| Mechanism of homologous recombination from the RecA-ssDNA/dsDNA structures | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, DNA (5'-D(*DAP*DAP*DAP*DAP*DAP*DAP*DAP*DAP*DAP*DAP*DAP*DA)-3'), DNA (5'-D(*DTP*DTP*DTP*DTP*DTP*DTP*DTP*DTP*DTP*DTP*DTP*DTP*DTP*DTP*DT)-3'), ... | Authors: | Pavletich, N.P. | Deposit date: | 2008-03-24 | Release date: | 2008-05-20 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Mechanism of homologous recombination from the RecA-ssDNA/dsDNA structures. Nature, 453, 2008
|
|
3CMW
| |
3CMV
| |
3CMU
| |
7JY6
| |
7JY9
| Structure of a 9 base pair RecA-D loop complex | Descriptor: | DNA (27-MER), DNA (42-MER), MAGNESIUM ION, ... | Authors: | Pavletich, N.P. | Deposit date: | 2020-08-29 | Release date: | 2020-11-04 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Mechanism of strand exchange from RecA-DNA synaptic and D-loop structures. Nature, 586, 2020
|
|
7JY8
| |
7JY7
| Structure of a 12 base pair RecA-D loop complex | Descriptor: | DNA (27-MER), DNA (48-MER), MAGNESIUM ION, ... | Authors: | Pavletich, N.P. | Deposit date: | 2020-08-29 | Release date: | 2020-11-04 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Mechanism of strand exchange from RecA-DNA synaptic and D-loop structures. Nature, 586, 2020
|
|
1IYJ
| STRUCTURE OF A BRCA2-DSS1 COMPLEX | Descriptor: | Deleted in split hand/split foot protein 1, breast cancer susceptibility | Authors: | Pavletich, N.P, Jeffrey, P.D, Yang, H.J. | Deposit date: | 2002-08-28 | Release date: | 2002-10-02 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure. Science, 297, 2002
|
|
1J8F
| |
7SIC
| Human ATM Dimer | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Serine-protein kinase ATM | Authors: | Warren, C, Pavletich, N.P. | Deposit date: | 2021-10-13 | Release date: | 2022-02-02 | Method: | ELECTRON MICROSCOPY (2.51 Å) | Cite: | Structure of the human ATM kinase and mechanism of Nbs1 binding. Elife, 11, 2022
|
|
7SID
| Human ATM Dimer Bound to Nbs1 | Descriptor: | MAGNESIUM ION, Nibrin, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | Authors: | Warren, C, Pavletich, N.P. | Deposit date: | 2021-10-13 | Release date: | 2022-02-02 | Method: | ELECTRON MICROSCOPY (2.53 Å) | Cite: | Structure of the human ATM kinase and mechanism of Nbs1 binding. Elife, 11, 2022
|
|
1D5R
| Crystal Structure of the PTEN Tumor Suppressor | Descriptor: | L(+)-TARTARIC ACID, PHOSPHOINOSITIDE PHOSPHATASE PTEN | Authors: | Lee, J.O, Yang, H, Georgescu, M.-M, Di Cristofano, A, Pavletich, N.P. | Deposit date: | 1999-10-11 | Release date: | 1999-11-04 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association. Cell(Cambridge,Mass.), 99, 1999
|
|
1D5F
| STRUCTURE OF E6AP: INSIGHTS INTO UBIQUITINATION PATHWAY | Descriptor: | E6AP HECT CATALYTIC DOMAIN, E3 LIGASE | Authors: | Huang, L, Kinnucan, E, Wang, G, Beaudenon, S, Howley, P.M, Huibregtse, J.M, Pavletich, N.P. | Deposit date: | 1999-10-07 | Release date: | 1999-11-17 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascade. Science, 286, 1999
|
|
1CF7
| STRUCTURAL BASIS OF DNA RECOGNITION BY THE HETERODIMERIC CELL CYCLE TRANSCRIPTION FACTOR E2F-DP | Descriptor: | DNA (5'-D(*AP*TP*TP*TP*TP*CP*GP*CP*GP*CP*GP*GP*TP*TP*TP*T)-3'), DNA (5'-D(*TP*AP*AP*AP*AP*CP*CP*GP*CP*GP*CP*GP*AP*AP*AP*A)-3'), PROTEIN (TRANSCRIPTION FACTOR DP-2), ... | Authors: | Zheng, N, Fraenkel, E, Pabo, C.O, Pavletich, N.P. | Deposit date: | 1999-03-24 | Release date: | 1999-04-02 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural basis of DNA recognition by the heterodimeric cell cycle transcription factor E2F-DP. Genes Dev., 13, 1999
|
|
6MGN
| mouse Id1 (51-104) - human hE47 (348-399) complex | Descriptor: | DNA-binding protein inhibitor ID-1, Transcription factor E2-alpha | Authors: | Benezra, R, Pavletich, N.P, Gall, A.-L, Goldgur, Y. | Deposit date: | 2018-09-14 | Release date: | 2019-09-18 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.901 Å) | Cite: | A Small-Molecule Pan-Id Antagonist Inhibits Pathologic Ocular Neovascularization. Cell Rep, 29, 2019
|
|