4RIB

FAN1 Nuclease bound to 5' phosphorylated p(dT) single flap DNA

Summary for 4RIB

• Entry DOI: 10.2210/pdb4rib/pdb
• Related: 4RI8 4RI9 4RIA 4RIC 4RID
• Descriptor: Fanconi-associated nuclease 1, DNA (5'-D(P*TP*AP*GP*CP*CP*AP*CP*GP*CP*CP*TP*AP*GP*AP*CP*TP*CP*CP*TP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*GP*GP*AP*GP*TP*CP*T)-3'), ... (5 entities in total)
• Functional Keywords: nuclease, hydrolase-dna complex, hydrolase/dna
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus : Q9Y2M0
• Total number of polymer chains: 8
• Total formula weight: 176064.46

Authors

Pavletich, N.P.,Wang, R. (deposition date: 2014-10-05, release date: 2014-12-03, Last modification date: 2024-02-28)

• Primary citation: Wang, R.,Persky, N.S.,Yoo, B.,Ouerfelli, O.,Smogorzewska, A.,Elledge, S.J.,Pavletich, N.P.; DNA repair. Mechanism of DNA interstrand cross-link processing by repair nuclease FAN1.; Science, 346:1127-1130, 2014; PubMed: 25430771; DOI: 10.1126/science.1258973

Experimental method

X-RAY DIFFRACTION (3.25 Å)