1D5R

Crystal Structure of the PTEN Tumor Suppressor

Summary for 1D5R

Entry DOI	10.2210/pdb1d5r/pdb
Descriptor	PHOSPHOINOSITIDE PHOSPHATASE PTEN, L(+)-TARTARIC ACID (3 entities in total)
Functional Keywords	c2 domain, phosphotidylinositol, phosphatase, hydrolase
Biological source	Homo sapiens (human) More
Cellular location	Cytoplasm . Isoform alpha: Secreted : P60484
Total number of polymer chains	1
Total formula weight	38646.27
Authors	Lee, J.O.,Yang, H.,Georgescu, M.-M.,Di Cristofano, A.,Pavletich, N.P. (deposition date: 1999-10-11, release date: 1999-11-04, Last modification date: 2024-02-07)
Primary citation	Lee, J.O.,Yang, H.,Georgescu, M.M.,Di Cristofano, A.,Maehama, T.,Shi, Y.,Dixon, J.E.,Pandolfi, P.,Pavletich, N.P. Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association. Cell(Cambridge,Mass.), 99:323-334, 1999 Cited by PubMed: 10555148 DOI: 10.1016/S0092-8674(00)81663-3 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation