1D5R

Crystal Structure of the PTEN Tumor Suppressor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016311	biological_process	dephosphorylation
A	0016791	molecular_function	phosphatase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE TLA A 1352

Chain	Residue
A	ASP92
A	HOH1439
A	HIS93
A	CYS124
A	LYS125
A	ALA126
A	GLY129
A	ARG130
A	GLN171
A	HOH1381

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Functional Information from PROSITE/UniProt

site_id	PS00383
Number of Residues	11
Details	TYR_PHOSPHATASE_1 Tyrosine specific protein phosphatases active site. IHCkaGkgRTG

Chain	Residue	Details
A	ILE122-GLY132

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Phosphocysteine intermediate => ECO:0000255|PROSITE-ProRule:PRU00590

Chain	Residue	Details
A	CYS124

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:O08586

Chain	Residue	Details
A	VAL317

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site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0000269|PubMed:26166433

Chain	Residue	Details
A	THR319
A	THR321

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphotyrosine; by FRK => ECO:0000269|PubMed:19345329

Chain	Residue	Details
A	TYR336

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site_id	SWS_FT_FI5
Number of Residues	3
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:18716620

Chain	Residue	Details
A	LYS13
A	ASP312

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	a catalytic site defined by CSA, PubMed 9593664, 10555148

Chain	Residue	Details
A	ASP92

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site_id	MCSA1
Number of Residues	3
Details	M-CSA 456

Chain	Residue	Details
A	ASP92	proton shuttle (general acid/base)
A	CYS124	covalent catalysis
A	ARG130	transition state stabiliser

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