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PDB: 62 件
4M4Q
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6-(4-fluorophenyl)-3-hydroxy-5-[4-(1H-1,2,3,4-tetrazol-5-yl)phenyl] -1,2-dihydropyridin-2-one bound to influenza 2009 H1N1 endonuclease
分子名称: 6-(4-fluorophenyl)-5-[4-(1H-tetrazol-5-yl)phenyl]pyridine-2,3-diol, MAGNESIUM ION, MANGANESE (II) ION, ...
著者Bauman, J.D, Patel, D, Das, K, Arnold, E.
登録日2013-08-07
公開日2013-09-18
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.502 Å)
主引用文献Crystallographic fragment screening and structure-based optimization yields a new class of influenza endonuclease inhibitors.
Acs Chem.Biol., 8, 2013
4M5U
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BU of 4m5u by Molmil
5-(4-FLUOROPHENYL)-3-HYDROXY-6-[4-(1H-1,2,3,4-TETRAZOL-5-YL)PHENYL]-1,2-DIHYDROPYRIDIN-2-ONE bound to influenza 2009 pH1N1 endonuclease
分子名称: 5-(4-fluorophenyl)-3-hydroxy-6-[4-(1H-tetrazol-5-yl)phenyl]pyridin-2(1H)-one, MANGANESE (II) ION, Polymerase PA, ...
著者Bauman, J.D, Patel, D, Das, K, Arnold, E.
登録日2013-08-08
公開日2013-09-25
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Phenyl substituted 3-hydroxypyridin-2(1H)-ones: inhibitors of influenza A endonuclease.
Bioorg.Med.Chem., 21, 2013
4M5Q
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BU of 4m5q by Molmil
High-resolution apo influenza 2009 H1N1 endonuclease structure
分子名称: 1,2-ETHANEDIOL, MANGANESE (II) ION, Polymerase PA
著者Bauman, J.D, Patel, D, Das, K, Arnold, E.
登録日2013-08-08
公開日2013-09-18
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.534 Å)
主引用文献Crystallographic fragment screening and structure-based optimization yields a new class of influenza endonuclease inhibitors.
Acs Chem.Biol., 8, 2013
4MK1
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BU of 4mk1 by Molmil
5-bromopyridine-2,3-diol bound to influenza 2009 pH1N1 endonuclease
分子名称: 1,2-ETHANEDIOL, 5-bromo-3-hydroxypyridin-2(1H)-one, MANGANESE (II) ION, ...
著者Bauman, J.D, Patel, D, Das, K, Arnold, E.
登録日2013-09-04
公開日2013-09-25
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Crystallographic fragment screening and structure-based optimization yields a new class of influenza endonuclease inhibitors.
Acs Chem.Biol., 8, 2013
4MK5
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BU of 4mk5 by Molmil
6-(3-methoxyphenyl)pyridine-2,3-diol bound to influenza 2009 pH1N1 endonuclease
分子名称: 1,2-ETHANEDIOL, 3-hydroxy-6-(3-methoxyphenyl)pyridin-2(5H)-one, MANGANESE (II) ION, ...
著者Bauman, J.D, Patel, D, Das, K, Arnold, E.
登録日2013-09-04
公開日2013-09-25
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystallographic fragment screening and structure-based optimization yields a new class of influenza endonuclease inhibitors.
Acs Chem.Biol., 8, 2013
4MK2
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3-(5-hydroxy-6-oxo-1,6-dihydropyridin-3-yl)benzonitrile bound to influenza 2009 pH1N1 endonuclease
分子名称: 1,2-ETHANEDIOL, 3-(5-hydroxy-6-oxo-1,6-dihydropyridin-3-yl)benzonitrile, MANGANESE (II) ION, ...
著者Bauman, J.D, Patel, D, Das, K, Arnold, E.
登録日2013-09-04
公開日2013-09-25
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Crystallographic fragment screening and structure-based optimization yields a new class of influenza endonuclease inhibitors.
Acs Chem.Biol., 8, 2013
4M5O
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BU of 4m5o by Molmil
3-HYDROXY-6-PHENYL-1,2-DIHYDROPYRIDIN-2-ONE bound to influenza 2009 H1N1 endonuclease
分子名称: 1,2-ETHANEDIOL, 3-hydroxy-6-phenylpyridin-2(5H)-one, MANGANESE (II) ION, ...
著者Bauman, J.D, Patel, D, Das, K, Arnold, E.
登録日2013-08-08
公開日2013-09-18
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystallographic fragment screening and structure-based optimization yields a new class of influenza endonuclease inhibitors.
Acs Chem.Biol., 8, 2013
2L69
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BU of 2l69 by Molmil
Solution NMR Structure of de novo designed protein, P-loop NTPase fold, Northeast Structural Genomics Consortium Target OR28
分子名称: Rossmann 2x3 fold protein
著者Liu, G, Koga, N, Koga, R, Xiao, R, Mao, A, Mao, B, Patel, D, Ciccosanti, C, Hamilton, K, Acton, T.B, Baker, D, Montelione, G.T, Northeast Structural Genomics Consortium (NESG)
登録日2010-11-17
公開日2011-01-12
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Solution NMR structure of de novo designed rossmann 2x3 fold protein, Northeast Structural Genomics Consortium Target OR28
To be Published
2LA5
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BU of 2la5 by Molmil
RNA Duplex-Quadruplex Junction Complex with FMRP RGG peptide
分子名称: Fragile X mental retardation 1 protein, RNA (36-MER)
著者Phan, A, Kuryavyi, V, Darnell, J, Serganov, A, Majumdar, A, Ilin, S, Darnell, R, Patel, D.
登録日2011-03-03
公開日2011-06-08
最終更新日2024-05-01
実験手法SOLUTION NMR
主引用文献Structure-function studies of FMRP RGG peptide recognition of an RNA duplex-quadruplex junction.
Nat.Struct.Mol.Biol., 18, 2011
4DIU
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BU of 4diu by Molmil
Crystal Structure of Engineered Protein. Northeast Structural Genomics Consortium Target OR94
分子名称: Engineered Protein PF00326
著者Seetharaman, J, Lew, S, Wang, D, Kohan, E, Patel, D, Whitehead, T, Fleishman, S, Ciccosanti, C, Xiao, R, Everett, J.K, Acton, T.B, Baker, D, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG)
登録日2012-01-31
公開日2012-04-11
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal Structure of Engineered Protein. Northeast Structural Genomics Consortium Target OR94
To be Published
5JA4
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BU of 5ja4 by Molmil
Crystal structure of human TONSL and MCM2 HBDs binding to a histone H3-H4 tetramer
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, DNA replication licensing factor MCM2, GLYCEROL, ...
著者Huang, H, Patel, D.
登録日2016-04-11
公開日2016-06-15
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.424 Å)
主引用文献H4K20me0 marks post-replicative chromatin and recruits the TONSL-MMS22L DNA repair complex.
Nature, 534, 2016
5K7E
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BU of 5k7e by Molmil
The structure of pistol ribozyme, soaked with Mn2+
分子名称: DNA/RNA 11-MER, MANGANESE (II) ION, RNA 47-MER
著者Ren, A, Patel, D.
登録日2016-05-26
公開日2016-07-13
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.27 Å)
主引用文献Pistol ribozyme adopts a pseudoknot fold facilitating site-specific in-line cleavage.
Nat.Chem.Biol., 12, 2016
5K7C
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BU of 5k7c by Molmil
The native structure of native pistol ribozyme
分子名称: DNA/RNA 11-MER, MAGNESIUM ION, RNA 47-MER
著者Ren, A, Patel, D.
登録日2016-05-26
公開日2016-07-13
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.73 Å)
主引用文献Pistol ribozyme adopts a pseudoknot fold facilitating site-specific in-line cleavage.
Nat.Chem.Biol., 12, 2016
5K7D
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BU of 5k7d by Molmil
The structure of native pistol ribozyme, bound to Iridium
分子名称: DNA/RNA 11-MER, IRIDIUM HEXAMMINE ION, MAGNESIUM ION, ...
著者Ren, A, Patel, D.
登録日2016-05-26
公開日2016-07-13
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.68 Å)
主引用文献Pistol ribozyme adopts a pseudoknot fold facilitating site-specific in-line cleavage.
Nat.Chem.Biol., 12, 2016
5KDM
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BU of 5kdm by Molmil
Crystal structure of EBV tegument protein BNRF1 in complex with histone chaperone DAXX and histones H3.3-H4
分子名称: Death domain-associated protein 6, Histone H3.3, Histone H4, ...
著者Huang, H, Patel, D.
登録日2016-06-08
公開日2016-09-07
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献Structural basis underlying viral hijacking of a histone chaperone complex.
Nat Commun, 7, 2016
1SI2
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BU of 1si2 by Molmil
Crystal structure of the PAZ domain of human eIF2c1 in complex with a 9-mer siRNA-like duplex of deoxynucleotide overhang
分子名称: 5'-R(*CP*GP*UP*GP*AP*CP*U)-D(P*CP*T)-3', Eukaryotic translation initiation factor 2C 1
著者Ye, K, Ma, J.B, Patel, D.
登録日2004-02-26
公開日2004-05-25
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural basis for overhang-specific small interfering RNA recognition by the PAZ domain.
Nature, 429, 2004
5DDO
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BU of 5ddo by Molmil
Structural and Dynamic Basis for Low Affinity-High Selectivity Binding of L-glutamine by the Gln-riboswitch
分子名称: L-glutamine riboswitch (58-MER), U1 small nuclear ribonucleoprotein A
著者Ren, A, Patel, D.
登録日2015-08-25
公開日2015-12-23
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Structural and Dynamic Basis for Low-Affinity, High-Selectivity Binding of L-Glutamine by the Glutamine Riboswitch.
Cell Rep, 13, 2015
1SI3
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BU of 1si3 by Molmil
Crystal structure of the PAZ domain of human eIF2c1 in complex with a 9-mer siRNA-like duplex
分子名称: 5'-R(*CP*GP*UP*GP*AP*CP*UP*CP*U)-3', Eukaryotic translation initiation factor 2C 1
著者Ye, K, Ma, J.B, Patel, D.
登録日2004-02-27
公開日2004-05-25
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural basis for overhang-specific small interfering RNA recognition by the PAZ domain.
Nature, 429, 2004
2KRT
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BU of 2krt by Molmil
Solution NMR Structure of a Conserved Hypothetical Membrane Lipoprotein Obtained from Ureaplasma parvum: Northeast Structural Genomics Consortium Target UuR17A (139-239)
分子名称: Conserved hypothetical membrane lipoprotein
著者Mani, R, Swapna, G, Janjua, H, Ciccosanti, C, Huang, Y, Patel, D, Xiao, R, Acton, T, Everett, J, Montelione, G.T, Northeast Structural Genomics Consortium (NESG)
登録日2009-12-22
公開日2010-01-05
最終更新日2024-05-08
実験手法SOLUTION NMR
主引用文献NMR Solution Structure of a Conserved Hypothetical Membrane Lipoprotein obtained from Ureaplasma parvum : Northeast Structural Genomics Consortium Target UuR17A (139-239)
To be Published
2L81
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BU of 2l81 by Molmil
Solution NMR Structure of the serine-rich domain of hEF1 (Enhancer of filamentation 1) from Homo sapiens, Northeast Structural Genomics Consortium Target HR5554A
分子名称: Enhancer of filamentation 1
著者Liu, G, Xiao, R, Huang, Y.J, Patel, D, Ciccosanti, C.T, Acton, T.B, Tong, S, Everett, J.T, Montelione, G.T, Northeast Structural Genomics Consortium (NESG)
登録日2010-12-31
公開日2011-02-09
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Northeast Structural Genomics Consortium Target HR5554A
To be Published
4G1Q
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BU of 4g1q by Molmil
Crystal structure of HIV-1 reverse transcriptase (RT) in complex with Rilpivirine (TMC278, Edurant), a non-nucleoside rt-inhibiting drug
分子名称: 1,2-ETHANEDIOL, 4-{[4-({4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile, MAGNESIUM ION, ...
著者Bauman, J.D, Patel, D, Das, K, Arnold, E.
登録日2012-07-11
公開日2013-02-06
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.51 Å)
主引用文献Snapshot of the equilibrium dynamics of a drug bound to HIV-1 reverse transcriptase.
Nat Chem, 5, 2013
3PGR
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BU of 3pgr by Molmil
Asp348Arg mutant of EcFadL
分子名称: (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, Long-chain fatty acid transport protein
著者Lepore, B.W, van den Berg, B, Indic, M, Hearn, E, Patel, D, Pham, H.
登録日2010-11-02
公開日2011-05-25
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献From the Cover: Ligand-gated diffusion across the bacterial outer membrane.
Proc.Natl.Acad.Sci.USA, 108, 2011
3PGU
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BU of 3pgu by Molmil
Phe3Glu mutant of EcFadL
分子名称: (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, Long-chain fatty acid transport protein, NICKEL (II) ION, ...
著者Lepore, B.W, Indic, M, Pham, H, Hearn, E, Patel, D, van den Berg, B.
登録日2010-11-02
公開日2011-05-25
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献From the Cover: Ligand-gated diffusion across the bacterial outer membrane.
Proc.Natl.Acad.Sci.USA, 108, 2011
2KU7
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BU of 2ku7 by Molmil
Solution structure of MLL1 PHD3-Cyp33 RRM chimeric protein
分子名称: MLL1 PHD3-Cyp33 RRM chimeric protein
著者Song, J, Wang, Z, Patel, D.
登録日2010-02-12
公開日2010-07-07
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献Pro isomerization in MLL1 PHD3-bromo cassette connects H3K4me readout to CyP33 and HDAC-mediated repression.
Cell(Cambridge,Mass.), 141, 2010
3PF1
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BU of 3pf1 by Molmil
E. coli FadL Asp348Ala mutant
分子名称: (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, LAURYL DIMETHYLAMINE-N-OXIDE, Long-chain fatty acid transport protein
著者Vandenberg, B, Lepore, B.W, Hearn, E.M, Indic, M, Patel, D.
登録日2010-10-27
公開日2011-05-25
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献From the Cover: Ligand-gated diffusion across the bacterial outer membrane.
Proc.Natl.Acad.Sci.USA, 108, 2011

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