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PDB: 153 件
3KEN
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BU of 3ken by Molmil
Human Eg5 in complex with S-trityl-L-cysteine
分子名称: ADENOSINE-5'-DIPHOSPHATE, Kinesin-like protein KIF11, MAGNESIUM ION, ...
著者Parke, C.L, Wojcik, E.J, Kim, S, Worthylake, D.K.
登録日2009-10-26
公開日2010-03-16
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Allosteric drug discrimination is coupled to mechanochemical changes in the kinesin-5 motor core.
J.Biol.Chem., 285, 2010
3HQD
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BU of 3hqd by Molmil
Human kinesin Eg5 motor domain in complex with AMPPNP and Mg2+
分子名称: Kinesin-like protein KIF11, MAGNESIUM ION, PHOSPHATE ION, ...
著者Parke, C.L, Wojcik, E.J, Kim, S, Worthylake, D.K.
登録日2009-06-05
公開日2009-12-08
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.19 Å)
主引用文献ATP Hydrolysis in Eg5 Kinesin Involves a Catalytic Two-water Mechanism.
J.Biol.Chem., 285, 2010
1M82
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BU of 1m82 by Molmil
SOLUTION STRUCTURE OF THE COMPLEMENTARY RNA PROMOTER OF INFLUENZA A VIRUS
分子名称: RNA (25-MER): THE COMPLEMENTARY RNA PROMOTER OF INFLUENZA A VIRUS
著者Park, C.-J, Bae, S.-H, Lee, M.-K, Varani, G, Choi, B.-S.
登録日2002-07-24
公開日2003-06-03
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献Solution structure of the influenza A virus cRNA promoter: implications for differential recognition of viral promoter structures by RNA-dependent RNA polymerase
NUCLEIC ACIDS RES., 31, 2003
3GN7
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BU of 3gn7 by Molmil
PARP complexed with A861696
分子名称: 2-[(2S)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-7-carboxamide, Poly [ADP-ribose] polymerase 1
著者Park, C.H.
登録日2009-03-16
公開日2010-03-16
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献PARP complexed with A861696
To be Published
3GJW
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BU of 3gjw by Molmil
PARP complexed with A968427
分子名称: 7-(pyrrolidin-1-ylmethyl)pyrrolo[1,2-a]quinoxalin-4(5H)-one, Poly [ADP-ribose] polymerase 1
著者Park, C.H.
登録日2009-03-09
公開日2010-03-09
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Synthesis and SAR of novel tricyclic quinoxalinone inhibitors of poly(ADP-ribose)polymerase-1 (PARP-1)
Bioorg.Med.Chem.Lett., 19, 2009
3L3L
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BU of 3l3l by Molmil
PARP complexed with A906894
分子名称: 3-oxo-2-piperidin-4-yl-2,3-dihydro-1H-isoindole-4-carboxamide, Poly [ADP-ribose] polymerase 1
著者Park, C.H.
登録日2009-12-17
公開日2010-12-22
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Discovery and SAR of substituted 3-oxoisoindoline-4-carboxamides as potent inhibitors of poly(ADP-ribose) polymerase (PARP) for the treatment of cancer.
Bioorg.Med.Chem.Lett., 20, 2010
1YNX
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BU of 1ynx by Molmil
Solution structure of DNA binding domain A (DBD-A) of S.cerevisiae Replication Protein A (RPA)
分子名称: Replication factor-A protein 1
著者Park, C.J, Lee, J.H, Choi, B.S.
登録日2005-01-26
公開日2006-01-10
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Solution structure of the DNA-binding domain of RPA from Saccharomyces cerevisiae and its interaction with single-stranded DNA and SV40 T antigen
Nucleic Acids Res., 33, 2005
5UER
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BU of 5uer by Molmil
BRD4_BD2_A-1359930
分子名称: Bromodomain-containing protein 4, N-[3-(3-methyl-4-oxo-4,5,6,7-tetrahydro-2H-isoindol-1-yl)-4-phenoxyphenyl]methanesulfonamide
著者Park, C.H.
登録日2017-01-03
公開日2017-06-14
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (1.87 Å)
主引用文献Complex structure of BRD4_BD2_A-1359930
To Be Published
5UEP
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BU of 5uep by Molmil
BRD4_BD2_A-581577
分子名称: Bromodomain-containing protein 4, ethyl 3-methyl-4-oxo-4,5,6,7-tetrahydro-2H-isoindole-1-carboxylate
著者Park, C.H.
登録日2017-01-03
公開日2017-06-14
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.77 Å)
主引用文献Complex structure of BRD4_BD2_A-581577
To Be Published
5UET
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BU of 5uet by Molmil
BRD4_BD2_A-1308586
分子名称: 2-methyl-5-phenyl-1H-pyrrole-3-carboxamide, Bromodomain-containing protein 4
著者Park, C.H.
登録日2017-01-03
公開日2017-06-14
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.29 Å)
主引用文献Complex structure of BRD4_BD2_A-1308586
To Be Published
3OWB
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BU of 3owb by Molmil
Crystal Structure of HSP90 with VER-49009
分子名称: 5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-(4-METHOXYPHENYL)-1H-PYRAZOLE-3-CARBOXAMIDE, Heat shock protein HSP 90-alpha
著者Park, C.H.
登録日2010-09-17
公開日2011-09-21
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献N-aryl-benzimidazolones as novel small molecule HSP90 inhibitors.
Bioorg.Med.Chem.Lett., 20, 2010
3OW6
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BU of 3ow6 by Molmil
Crystal Structure of HSP90 with N-Aryl-benzimidazolone I
分子名称: 1-(2,4-dihydroxyphenyl)-1,3-dihydro-2H-benzimidazol-2-one, Heat shock protein HSP 90-alpha
著者Park, C.H.
登録日2010-09-17
公開日2011-09-21
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献N-aryl-benzimidazolones as novel small molecule HSP90 inhibitors.
Bioorg.Med.Chem.Lett., 20, 2010
3OWD
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BU of 3owd by Molmil
Crystal Structure of HSP90 with N-Aryl-benzimidazolone II
分子名称: Heat shock protein HSP 90-alpha, N-{[1-(5-chloro-2,4-dihydroxyphenyl)-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl]methyl}naphthalene-1-sulfonamide
著者Park, C.H.
登録日2010-09-17
公開日2011-09-21
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.63 Å)
主引用文献N-aryl-benzimidazolones as novel small molecule HSP90 inhibitors.
Bioorg.Med.Chem.Lett., 20, 2010
1C9X
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BU of 1c9x by Molmil
H119A VARIANT OF RIBONUCLEASE A
分子名称: CHLORIDE ION, RIBONUCLEASE A
著者Park, C, Schultz, L.W, Raines, R.T.
登録日1999-08-03
公開日2001-06-27
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Contribution of the active site histidine residues of ribonuclease A to nucleic acid binding.
Biochemistry, 40, 2001
1C9V
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BU of 1c9v by Molmil
H12A VARIANT OF RIBONUCLEASE A
分子名称: CHLORIDE ION, RIBONUCLEASE A
著者Park, C, Schultz, L.W, Raines, R.T.
登録日1999-08-03
公開日2001-06-27
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Contribution of the active site histidine residues of ribonuclease A to nucleic acid binding.
Biochemistry, 40, 2001
1YW7
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BU of 1yw7 by Molmil
h-MetAP2 complexed with A444148
分子名称: 5-METHYL-2-[(PHENYLSULFONYL)AMINO]BENZOIC ACID, MANGANESE (II) ION, Methionine aminopeptidase 2
著者Park, C.H.
登録日2005-02-17
公開日2006-02-21
最終更新日2024-11-13
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Discovery and optimization of anthranilic acid sulfonamides as inhibitors of methionine aminopeptidase-2: a structural basis for the reduction of albumin binding.
J.Med.Chem., 49, 2006
1YW8
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BU of 1yw8 by Molmil
h-MetAP2 complexed with A751277
分子名称: 2-[(PHENYLSULFONYL)AMINO]-5,6,7,8-TETRAHYDRONAPHTHALENE-1-CARBOXYLIC ACID, MANGANESE (II) ION, Methionine aminopeptidase 2
著者Park, C.H.
登録日2005-02-17
公開日2006-02-21
最終更新日2024-11-20
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Discovery and optimization of anthranilic acid sulfonamides as inhibitors of methionine aminopeptidase-2: a structural basis for the reduction of albumin binding.
J.Med.Chem., 49, 2006
1YW9
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BU of 1yw9 by Molmil
h-MetAP2 complexed with A849519
分子名称: 2-[({2-[(1Z)-3-(DIMETHYLAMINO)PROP-1-ENYL]-4-FLUOROPHENYL}SULFONYL)AMINO]-5,6,7,8-TETRAHYDRONAPHTHALENE-1-CARBOXYLIC ACID, MANGANESE (II) ION, Methionine aminopeptidase 2
著者Park, C.H.
登録日2005-02-17
公開日2006-02-21
最終更新日2024-11-13
実験手法X-RAY DIFFRACTION (1.64 Å)
主引用文献Discovery and optimization of anthranilic acid sulfonamides as inhibitors of methionine aminopeptidase-2: a structural basis for the reduction of albumin binding.
J.Med.Chem., 49, 2006
1HXW
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BU of 1hxw by Molmil
HIV-1 PROTEASE DIMER COMPLEXED WITH A-84538
分子名称: HIV-1 PROTEASE, RITONAVIR
著者Park, C.H, Nienaber, V, Kong, X.P.
登録日1997-01-24
公開日1998-02-04
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献ABT-538 is a potent inhibitor of human immunodeficiency virus protease and has high oral bioavailability in humans.
Proc.Natl.Acad.Sci.USA, 92, 1995
5UEV
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BU of 5uev by Molmil
BRD4_BD2_A-556343
分子名称: 1-[5-(2-aminophenyl)-2-methyl-1H-pyrrol-3-yl]ethan-1-one, Bromodomain-containing protein 4
著者Park, C.H.
登録日2017-01-03
公開日2017-06-14
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.94 Å)
主引用文献Complex structure of BRD4_BD2_A-556343
To Be Published
5UES
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BU of 5ues by Molmil
BRD4_BD2_A-1344772
分子名称: 5-[2-(4-chlorophenoxy)phenyl]-2-methyl-1H-pyrrole-3-carboxamide, Bromodomain-containing protein 4
著者Park, C.H.
登録日2017-01-03
公開日2017-06-28
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.62 Å)
主引用文献Complex structure of BRD4_BD2_A-1344772
To Be Published
5UVU
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BU of 5uvu by Molmil
BRD4_BD2_A-1461028
分子名称: 7-(cyclopropylmethyl)-2-methyl-10-[(methylsulfonyl)methyl]-2,4,6,7-tetrahydro-3H-2,4,7-triazadibenzo[cd,f]azulen-3-one, Bromodomain-containing protein 4
著者Park, C.H.
登録日2017-02-20
公開日2017-06-21
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (1.66 Å)
主引用文献Complex structure of BRD4_BD2_A-1461028
To Be Published
5UVZ
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BU of 5uvz by Molmil
BRD4 Bromodomain 2 with A-1354689
分子名称: 3-methyl-5-(2-phenoxyphenyl)pyridin-2(1H)-one, Bromodomain-containing protein 4
著者Park, C.H.
登録日2017-02-20
公開日2017-06-14
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (1.63 Å)
主引用文献BRD4 Bromodomain 2 with A-1354689
To Be Published
5UEQ
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BU of 5ueq by Molmil
BRD4_BD2_A-1390146
分子名称: Bromodomain-containing protein 4, N-[3-(7-methyl-1-oxo-2,6-dihydro-1H-pyrrolo[3,4-d]pyridazin-5-yl)-4-phenoxyphenyl]ethanesulfonamide
著者Park, C.H.
登録日2017-01-03
公開日2017-06-14
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Complex structure of BRD4_BD2_A-1390146
To Be Published
5UVT
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BU of 5uvt by Molmil
BRD4_BD2_A-1454056
分子名称: 7-(cyclopropylmethyl)-2-methyl-10-[(propan-2-yl)sulfonyl]-2,4,6,7-tetrahydro-3H-2,4,7-triazadibenzo[cd,f]azulen-3-one, Bromodomain-containing protein 4
著者Park, C.H.
登録日2017-02-20
公開日2017-06-21
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.67 Å)
主引用文献Complex structure of BRD4_BD2_A-1454056
To Be Published

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