3OWD

Crystal Structure of HSP90 with N-Aryl-benzimidazolone II

Summary for 3OWD

Entry DOI	10.2210/pdb3owd/pdb
Related	3OW6 3OWB
Descriptor	Heat shock protein HSP 90-alpha, N-{[1-(5-chloro-2,4-dihydroxyphenyl)-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl]methyl}naphthalene-1-sulfonamide (3 entities in total)
Functional Keywords	hsp90, chaperone
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P07900
Total number of polymer chains	1
Total formula weight	23644.19
Authors	Park, C.H. (deposition date: 2010-09-17, release date: 2011-09-21, Last modification date: 2024-02-21)
Primary citation	Bruncko, M.,Tahir, S.K.,Song, X.,Chen, J.,Ding, H.,Huth, J.R.,Jin, S.,Judge, R.A.,Madar, D.J.,Park, C.H.,Park, C.M.,Petros, A.M.,Tse, C.,Rosenberg, S.H.,Elmore, S.W. N-aryl-benzimidazolones as novel small molecule HSP90 inhibitors. Bioorg.Med.Chem.Lett., 20:7503-7506, 2010 Cited by PubMed: 21106457 DOI: 10.1016/j.bmcl.2010.10.010 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.63 Å)

Structure validation