7U5W
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7U5X
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6UX9
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![BU of 6ux9 by Molmil](/molmil-images/mine/6ux9) | Crystal Structure Analysis of PIP4K2A | 分子名称: | N-[4-(5-{(Z)-[(2E)-2-imino-4-oxo-1,3-thiazolidin-5-ylidene]methyl}pyridin-3-yl)phenyl]methanesulfonamide, Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha | 著者 | Seo, H.-S, Dhe-Paganon, S. | 登録日 | 2019-11-07 | 公開日 | 2020-12-09 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.71 Å) | 主引用文献 | Discovery and Structure-Activity Relationship Study of ( Z )-5-Methylenethiazolidin-4-one Derivatives as Potent and Selective Pan-phosphatidylinositol 5-Phosphate 4-Kinase Inhibitors. J.Med.Chem., 63, 2020
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7S7G
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![BU of 7s7g by Molmil](/molmil-images/mine/7s7g) | Crystal Structure Analysis of Human VLCAD | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, Very long-chain specific acyl-CoA dehydrogenase, mitochondrial | 著者 | Seo, H.-S, Dhe-Paganon, S. | 登録日 | 2021-09-15 | 公開日 | 2022-09-28 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (1.34 Å) | 主引用文献 | Structural basis for defective membrane targeting of mutant enzyme in human VLCAD deficiency. Nat Commun, 13, 2022
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6VO4
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6V4E
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6V4G
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6V4H
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6V4F
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6VQM
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![BU of 6vqm by Molmil](/molmil-images/mine/6vqm) | Crystal Structure Analysis of human ACK1 | 分子名称: | 2-({4-[(3R,5S)-3,5-dimethylpiperazin-1-yl]-2-methoxyphenyl}amino)-9-methyl-5,7-dihydro-6H-pyrimido[5,4-d][1,3]benzodiazepin-6-one, Activated CDC42 kinase 1, SULFATE ION | 著者 | Seo, H.-S, Dhe-Paganon, S. | 登録日 | 2020-02-05 | 公開日 | 2021-02-10 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.87 Å) | 主引用文献 | Crystal Structure Analysis of human ACK1 To Be Published
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6XAW
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5TWX
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![BU of 5twx by Molmil](/molmil-images/mine/5twx) | Crystal Structure of BRD9 bromodomain | 分子名称: | Bromodomain-containing protein 9, N-[6-({2-[(3S)-2,6-dioxopiperidin-3-yl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}oxy)hexyl]-2-(4-{2-[N-(1,1-dioxo-1lambda~6~-thian-4-yl)carbamimidoyl]-5-methyl-4-oxo-4,5-dihydrothieno[3,2-c]pyridin-7-yl}-2-methoxyphenoxy)acetamide | 著者 | Seo, H.-S, Dhe-Paganon, S. | 登録日 | 2016-11-15 | 公開日 | 2017-09-27 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | Degradation of the BAF Complex Factor BRD9 by Heterobifunctional Ligands. Angew. Chem. Int. Ed. Engl., 56, 2017
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5TWU
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![BU of 5twu by Molmil](/molmil-images/mine/5twu) | Structure of Maternal Embryonic Leucine Zipper Kinase | 分子名称: | Maternal embryonic leucine zipper kinase | 著者 | Li, Q, Seo, H.-S, Huang, H.-T, Gray, N.S, Dhe-Paganon, S, Eck, M.J. | 登録日 | 2016-11-14 | 公開日 | 2017-11-22 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.603 Å) | 主引用文献 | MELK is not necessary for the proliferation of basal-like breast cancer cells. Elife, 6, 2017
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5TWL
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![BU of 5twl by Molmil](/molmil-images/mine/5twl) | Structure of Maternal Embryonic Leucine Zipper Kinase | 分子名称: | 9-(3,5-dichloro-4-hydroxyphenyl)-1-{trans-4-[(dimethylamino)methyl]cyclohexyl}-3,4-dihydropyrimido[5,4-c]quinolin-2(1H)-one, Maternal embryonic leucine zipper kinase | 著者 | Seo, H.-S, Huang, H.-T, Gray, N.S, Dhe-Paganon, S. | 登録日 | 2016-11-14 | 公開日 | 2017-11-22 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.42 Å) | 主引用文献 | MELK is not necessary for the proliferation of basal-like breast cancer cells. Elife, 6, 2017
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5TX3
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![BU of 5tx3 by Molmil](/molmil-images/mine/5tx3) | Structure of Maternal Embryonic Leucine Zipper Kinase | 分子名称: | 7-[(1S)-4-hydroxy-2,3-dihydro-1H-inden-1-yl]-5,5-dimethyl-2-({3-[(pyrrolidin-1-yl)methyl]phenyl}amino)-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one, Maternal embryonic leucine zipper kinase | 著者 | Li, Q, Seo, H.-S, Huang, H.-T, Gray, N.S, Dhe-Paganon, S, Eck, M.J. | 登録日 | 2016-11-15 | 公開日 | 2017-11-22 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | MELK is not necessary for the proliferation of basal-like breast cancer cells. Elife, 6, 2017
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5TWY
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2AWF
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![BU of 2awf by Molmil](/molmil-images/mine/2awf) | Structure of human Ubiquitin-conjugating enzyme E2 G1 | 分子名称: | Ubiquitin-conjugating enzyme E2 G1 | 著者 | Walker, J.R, Avvakumov, G.V, Xue, S, Newman, E.M, Finerty, P, Mackenzie, F, Weigelt, J, Sundstrom, M, Arrowsmith, C, Edwards, A, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | 登録日 | 2005-09-01 | 公開日 | 2005-09-20 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | A human ubiquitin conjugating enzyme (E2)-HECT E3 ligase structure-function screen. Mol Cell Proteomics, 11, 2012
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2F4W
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![BU of 2f4w by Molmil](/molmil-images/mine/2f4w) | Human ubiquitin-conjugating enzyme E2 J2 | 分子名称: | ubiquitin-conjugating enzyme E2, J2 | 著者 | Walker, J.R, Avvakumov, G.V, Xue, S, Finerty Jr, P.J, Newman, E.M, Mackenzie, F, Weigelt, J, Sundstrom, M, Arrowsmith, C, Edwards, A, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | 登録日 | 2005-11-24 | 公開日 | 2005-12-27 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | A human ubiquitin conjugating enzyme (E2)-HECT E3 ligase structure-function screen. Mol Cell Proteomics, 11, 2012
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6XDJ
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![BU of 6xdj by Molmil](/molmil-images/mine/6xdj) | Crystal Structure Analysis of MBP-SIN3 | 分子名称: | Maltodextrin-binding protein,Transcriptional regulatory protein SIN3, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranose | 著者 | Seo, H.-S, Dhe-Paganon, S. | 登録日 | 2020-06-10 | 公開日 | 2021-06-16 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal Structure Analysis of MBP-SIN3 To be published
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5TWZ
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3N3K
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![BU of 3n3k by Molmil](/molmil-images/mine/3n3k) | The catalytic domain of USP8 in complex with a USP8 specific inhibitor | 分子名称: | Ubiquitin, Ubiquitin carboxyl-terminal hydrolase 8, ZINC ION | 著者 | Walker, J.R, Avvakumov, G.V, Xue, S, Li, Y, Allali-Hassani, A, Lam, R, Ernst, A, Sidhu, S, Weigelt, J, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium, Structural Genomics Consortium (SGC) | 登録日 | 2010-05-20 | 公開日 | 2010-06-23 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | A strategy for modulation of enzymes in the ubiquitin system. Science, 339, 2013
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2ESL
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![BU of 2esl by Molmil](/molmil-images/mine/2esl) | Human Cyclophilin C in Complex with Cyclosporin A | 分子名称: | CALCIUM ION, CYCLOSPORIN A, Peptidyl-prolyl cis-trans isomerase C, ... | 著者 | Walker, J.R, Davis, T, Newman, E.M, Finerty Jr, P.J, Mackenzie, F, Weigelt, J, Sundstrom, M, Arrowsmith, C, Edwards, A, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | 登録日 | 2005-10-26 | 公開日 | 2005-12-13 | 最終更新日 | 2018-02-07 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases. PLoS Biol., 8, 2010
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2FAZ
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![BU of 2faz by Molmil](/molmil-images/mine/2faz) | Ubiquitin-Like Domain of Human Nuclear Zinc Finger Protein NP95 | 分子名称: | Ubiquitin-like containing PHD and RING finger domains protein 1 | 著者 | Walker, J.R, Wybenga-Groot, L, Doherty, R.S, Finerty Jr, P.J, Newman, E, Mackenzie, F.M, Weigelt, J, Sundstrom, M, Arrowsmith, C, Edwards, A, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | 登録日 | 2005-12-08 | 公開日 | 2005-12-20 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Ubiquitin-Like Domain of Human Nuclear Zinc Finger Protein NP95 To be Published
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5TVT
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![BU of 5tvt by Molmil](/molmil-images/mine/5tvt) | Structure of Maternal Embryonic Leucine Zipper Kinase | 分子名称: | 9-(3,5-dichloro-4-hydroxyphenyl)-1-{trans-4-[(dimethylamino)methyl]cyclohexyl}-3-methyl-3,4-dihydropyrimido[5,4-c][1,5]naphthyridin-2(1H)-one, Maternal embryonic leucine zipper kinase | 著者 | Seo, H.-Y, Huang, H, Gray, N.S, Dhe-Paganon, S. | 登録日 | 2016-11-10 | 公開日 | 2017-11-15 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.28 Å) | 主引用文献 | Structure of Maternal Embryonic Leucine Zipper Kinase To Be Published
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2FK9
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![BU of 2fk9 by Molmil](/molmil-images/mine/2fk9) | Human protein kinase C, eta | 分子名称: | protein kinase C, eta type | 著者 | Walker, J.R, Littler, D.R, Finerty Jr, P.J, MacKenzie, F, Newman, E.M, Weigelt, J, Sundstrom, M, Arrowsmith, C, Edwards, A, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | 登録日 | 2006-01-04 | 公開日 | 2006-01-17 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Structure of human protein kinase C eta (PKCeta) C2 domain and identification of phosphorylation sites. Biochem.Biophys.Res.Commun., 349, 2006
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