5TWL
Structure of Maternal Embryonic Leucine Zipper Kinase
Summary for 5TWL
Entry DOI | 10.2210/pdb5twl/pdb |
Related | 5TVT 5TWU 5TWY 5TWZ |
Descriptor | Maternal embryonic leucine zipper kinase, 9-(3,5-dichloro-4-hydroxyphenyl)-1-{trans-4-[(dimethylamino)methyl]cyclohexyl}-3,4-dihydropyrimido[5,4-c]quinolin-2(1H)-one (3 entities in total) |
Functional Keywords | kinase inhibitor, basal-like breast cancer, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 39881.07 |
Authors | Seo, H.-S.,Huang, H.-T.,Gray, N.S.,Dhe-Paganon, S. (deposition date: 2016-11-14, release date: 2017-11-22, Last modification date: 2024-03-06) |
Primary citation | Huang, H.T.,Seo, H.S.,Zhang, T.,Wang, Y.,Jiang, B.,Li, Q.,Buckley, D.L.,Nabet, B.,Roberts, J.M.,Paulk, J.,Dastjerdi, S.,Winter, G.E.,McLauchlan, H.,Moran, J.,Bradner, J.E.,Eck, M.J.,Dhe-Paganon, S.,Zhao, J.J.,Gray, N.S. MELK is not necessary for the proliferation of basal-like breast cancer cells. Elife, 6:-, 2017 Cited by PubMed: 28926338DOI: 10.7554/eLife.26693 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.42 Å) |
Structure validation
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