6E3Z
 
 | | Structure of Bace-1 in complex with Ligand 8 | | Descriptor: | Beta-secretase 1, N-{3-[(2R,3R)-5-amino-3-methyl-2-(trifluoromethyl)-3,6-dihydro-2H-1,4-oxazin-3-yl]-4-fluorophenyl}-3,5-dichloropyridine-2-carboxamide | | Authors: | Shaffer, P.L. | | Deposit date: | 2018-07-16 | | Release date: | 2019-09-11 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (1.94 Å) | | Cite: | Discovery and Chemical Development of JNJ-50138803, a Clinical Candidate BACE1 Inhibitor
Acs Symp.Ser., 1307, 2020
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4MAL
 | | TPR3 of FimV from P. aeruginosa (PAO1) | | Descriptor: | Motility protein FimV | | Authors: | Nguyen, Y, Zhang, K, Daniel-Ivad, M, Sugiman-Marangos, S.N, Junop, M.S, Burrows, L.L, Howell, P.L. | | Deposit date: | 2013-08-16 | | Release date: | 2014-08-20 | | Last modified: | 2016-02-24 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Crystal structure of TPR2 from FimV
To be Published
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3K90
 | | The Abscisic acid receptor PYR1 in complex with Abscisic Acid | | Descriptor: | (2Z,4E)-5-[(1S)-1-hydroxy-2,6,6-trimethyl-4-oxocyclohex-2-en-1-yl]-3-methylpenta-2,4-dienoic acid, ACETIC ACID, GLYCEROL, ... | | Authors: | Dupeux, F.D, Santiago, J, Rodriguez, P.L, Marquez, J.A. | | Deposit date: | 2009-10-15 | | Release date: | 2009-11-10 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | The abscisic acid receptor PYR1 in complex with abscisic acid.
Nature, 462, 2009
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5WFT
 | | PelB 319-436 from Pseudomonas aeruginosa PAO1 | | Descriptor: | PelB | | Authors: | Marmont, L.S, Howell, P.L. | | Deposit date: | 2017-07-12 | | Release date: | 2017-10-04 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (2.821 Å) | | Cite: | PelA and PelB proteins form a modification and secretion complex essential for Pel polysaccharide-dependent biofilm formation in Pseudomonas aeruginosa.
J. Biol. Chem., 292, 2017
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2AFP
 | | THE SOLUTION STRUCTURE OF TYPE II ANTIFREEZE PROTEIN REVEALS A NEW MEMBER OF THE LECTIN FAMILY | | Descriptor: | PROTEIN (SEA RAVEN TYPE II ANTIFREEZE PROTEIN) | | Authors: | Gronwald, W, Loewen, M.C, Lix, B, Daugulis, A.J, Sonnichsen, F.D, Davies, P.L, Sykes, B.D. | | Deposit date: | 1998-12-14 | | Release date: | 1998-12-23 | | Last modified: | 2024-10-09 | | Method: | SOLUTION NMR | | Cite: | The solution structure of type II antifreeze protein reveals a new member of the lectin family.
Biochemistry, 37, 1998
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6UH5
 | | Structural basis of COMPASS eCM recognition of the H2Bub nucleosome | | Descriptor: | Bre2, DNA (146-MER), H3 N-terminus, ... | | Authors: | Hsu, P.L, Shi, H, Zheng, N. | | Deposit date: | 2019-09-26 | | Release date: | 2019-11-20 | | Last modified: | 2019-12-18 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Structural Basis of H2B Ubiquitination-Dependent H3K4 Methylation by COMPASS.
Mol.Cell, 76, 2019
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8MSI
 | | TYPE III ANTIFREEZE PROTEIN ISOFORM HPLC 12 N14SQ44T | | Descriptor: | PROTEIN (ANTIFREEZE PROTEIN TYPE III) | | Authors: | Graether, S.P, Deluca, C.I, Baardsnes, J, Hill, G.A, Davies, P.L, Jia, Z. | | Deposit date: | 1999-01-24 | | Release date: | 1999-04-29 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Quantitative and qualitative analysis of type III antifreeze protein structure and function.
J.Biol.Chem., 274, 1999
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6AME
 | | TYPE III ANTIFREEZE PROTEIN ISOFORM HPLC 12 M21A | | Descriptor: | PROTEIN (ANTIFREEZE PROTEIN TYPE III) | | Authors: | Graether, S.P, Deluca, C.I, Baardsnes, J, Hill, G.A, Davies, P.L, Jia, Z. | | Deposit date: | 1999-01-24 | | Release date: | 1999-04-29 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Quantitative and qualitative analysis of type III antifreeze protein structure and function.
J.Biol.Chem., 274, 1999
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6LA8
 | | 349 bp di-nucleosome harboring cohesive DNA termini assembled with linker histone H1.0 | | Descriptor: | CALCIUM ION, DNA (349-MER), Histone H1.0, ... | | Authors: | Adhireksan, Z, Lee, P.L, Sharma, D, Davey, C.A. | | Deposit date: | 2019-11-12 | | Release date: | 2020-10-07 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (3.4 Å) | | Cite: | Near-atomic resolution structures of interdigitated nucleosome fibres.
Nat Commun, 11, 2020
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2POA
 | | Schistosoma mansoni Sm14 Fatty Acid-Binding Protein: improvement of protein stability by substitution of the single Cys62 residue | | Descriptor: | 14 kDa fatty acid-binding protein | | Authors: | Ramos, C.R.R, Oyama Jr, S, Sforca, M.L, Pertinhez, T.A, Ho, P.L, Spisni, A. | | Deposit date: | 2007-04-26 | | Release date: | 2008-06-10 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Stability improvement of the fatty acid binding protein Sm14 from S. mansoni by Cys replacement: Structural and functional characterization of a vaccine candidate.
Biochim.Biophys.Acta, 1794, 2009
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3BOW
 | | Structure of M-calpain in complex with Calpastatin | | Descriptor: | CALCIUM ION, Calpain small subunit 1, Calpain-2 catalytic subunit, ... | | Authors: | Hanna, R.A, Campbell, R.L, Davies, P.L. | | Deposit date: | 2007-12-17 | | Release date: | 2008-11-25 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Calcium-bound structure of calpain and its mechanism of inhibition by calpastatin.
Nature, 456, 2008
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6R62
 | | Crystal structure of a class II pyruvate aldolase from Sphingomonas wittichii RW1 in complex with hydroxypyruvate | | Descriptor: | 3-HYDROXYPYRUVIC ACID, ACETATE ION, BROMIDE ION, ... | | Authors: | Marsden, S.R, Mestrom, L, Hagedoorn, P.L, Bento, I, McMillan, D.G.G, Hanefeld, U. | | Deposit date: | 2019-03-26 | | Release date: | 2019-05-29 | | Last modified: | 2024-05-15 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | CH-Pi Interactions Promote the Conversion of Hydroxypyruvate in a Class II Pyruvate Aldolase
Adv.Synth.Catal., 2019
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4WCJ
 | | Structure of IcaB from Ammonifex degensii | | Descriptor: | CHLORIDE ION, Polysaccharide deacetylase, ZINC ION | | Authors: | Little, D.J, Bamford, N.C, Pokrovskaya, V, Robinson, H, Nitz, M, Howell, P.L. | | Deposit date: | 2014-09-04 | | Release date: | 2014-11-12 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Structural Basis for the De-N-acetylation of Poly-beta-1,6-N-acetyl-d-glucosamine in Gram-positive Bacteria.
J.Biol.Chem., 289, 2014
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4WCX
 | | Crystal structure of HydG: A maturase of the [FeFe]-hydrogenase | | Descriptor: | ALANINE, Biotin and thiamin synthesis associated, FE (III) ION, ... | | Authors: | Dinis, P.C, Harmer, J.E, Driesener, R.C, Roach, P.L. | | Deposit date: | 2014-09-05 | | Release date: | 2015-02-04 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.59 Å) | | Cite: | X-ray crystallographic and EPR spectroscopic analysis of HydG, a maturase in [FeFe]-hydrogenase H-cluster assembly.
Proc.Natl.Acad.Sci.USA, 112, 2015
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3BL6
 | | Crystal structure of Staphylococcus aureus 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase in complex with formycin A | | Descriptor: | (1S)-1-(7-amino-1H-pyrazolo[4,3-d]pyrimidin-3-yl)-1,4-anhydro-D-ribitol, 5'-methylthioadenosine nucleosidase/S-adenosylhomocysteine nucleosidase | | Authors: | Siu, K.K.W, Lee, J.E, Smith, G.D, Horvatin, C, Howell, P.L. | | Deposit date: | 2007-12-10 | | Release date: | 2008-06-10 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Structure of Staphylococcus aureus 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
Acta Crystallogr.,Sect.F, 64, 2008
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2QSU
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8Y9C
 | | De novo design mini-binder in complex with TcdB4 | | Descriptor: | De novo design Minibinder, Toxin B, ZINC ION | | Authors: | Lv, X.C, Lu, P.L. | | Deposit date: | 2024-02-06 | | Release date: | 2024-08-28 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | De novo design of mini-protein binders broadly neutralizing Clostridioides difficile toxin B variants.
Nat Commun, 15, 2024
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8Y9B
 | | TcdB1 in complex with mini-binder | | Descriptor: | De novo design mini-binder, Toxin B, ZINC ION | | Authors: | Lv, X.C, Lu, P.L. | | Deposit date: | 2024-02-06 | | Release date: | 2024-08-28 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | De novo design of mini-protein binders broadly neutralizing Clostridioides difficile toxin B variants.
Nat Commun, 15, 2024
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7AME
 | | TYPE III ANTIFREEZE PROTEIN ISOFORM HPLC 12 T15A | | Descriptor: | PROTEIN (ANTIFREEZE PROTEIN TYPE III) | | Authors: | Graether, S.P, Deluca, C.I, Baardsnes, J, Hill, G.A, Davies, P.L, Jia, Z. | | Deposit date: | 1999-01-24 | | Release date: | 1999-04-29 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Quantitative and qualitative analysis of type III antifreeze protein structure and function.
J.Biol.Chem., 274, 1999
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6SHT
 | | Molecular structure of mouse apoferritin resolved at 2.7 Angstroms with the Glacios cryo-microscope | | Descriptor: | FE (III) ION, Ferritin heavy chain, MAGNESIUM ION | | Authors: | Hamdi, F, Tueting, C, Semchonok, D, Kyrilis, F, Meister, A, Skalidis, I, Schmidt, L, Parthier, C, Stubbs, M.T, Kastritis, P.L. | | Deposit date: | 2019-08-08 | | Release date: | 2020-05-13 | | Last modified: | 2024-05-22 | | Method: | ELECTRON MICROSCOPY (2.73 Å) | | Cite: | 2.7 angstrom cryo-EM structure of vitrified M. musculus H-chain apoferritin from a compact 200 keV cryo-microscope.
Plos One, 15, 2020
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4U0P
 | | The Crystal Structure of Lipoyl Synthase in Complex with S-Adenosyl Homocysteine | | Descriptor: | IRON/SULFUR CLUSTER, Lipoyl synthase 2, S-ADENOSYL-L-HOMOCYSTEINE, ... | | Authors: | Harmer, J.E, Hiscox, M.J, Sandy, J, Dinis, P.C, Roach, P.L. | | Deposit date: | 2014-07-13 | | Release date: | 2014-08-20 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.623 Å) | | Cite: | Structures of lipoyl synthase reveal a compact active site for controlling sequential sulfur insertion reactions.
Biochem.J., 464, 2014
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7BGJ
 | | C. thermophilum Pyruvate Dehydrogenase Complex Core | | Descriptor: | Acetyltransferase component of pyruvate dehydrogenase complex | | Authors: | Tueting, C, Kastritis, P.L. | | Deposit date: | 2021-01-07 | | Release date: | 2021-02-10 | | Last modified: | 2024-05-01 | | Method: | ELECTRON MICROSCOPY (6.9 Å) | | Cite: | Integrative structure of a 10-megadalton eukaryotic pyruvate dehydrogenase complex from native cell extracts.
Cell Rep, 34, 2021
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5LLF
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4U0O
 | | Crystal structure of Thermosynechococcus elongatus Lipoyl Synthase 2 complexed with MTA and DTT | | Descriptor: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 5'-DEOXY-5'-METHYLTHIOADENOSINE, IRON/SULFUR CLUSTER, ... | | Authors: | Harmer, J.E, Hiscox, M.J, Dinis, P.C, Sandy, J, Roach, P.L. | | Deposit date: | 2014-07-13 | | Release date: | 2014-08-20 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Structures of lipoyl synthase reveal a compact active site for controlling sequential sulfur insertion reactions.
Biochem.J., 464, 2014
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2XVC
 | | Molecular and structural basis of ESCRT-III recruitment to membranes during archaeal cell division | | Descriptor: | CADMIUM ION, CDVA, SSO0911, ... | | Authors: | Samson, R.Y, Obita, T, Hodgson, B, Shaw, M.K, Chong, P.L, Williams, R.L, Bell, S.D. | | Deposit date: | 2010-10-25 | | Release date: | 2011-02-02 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Molecular and Structural Basis of Escrt-III Recruitment to Membranes During Archaeal Cell Division.
Mol.Cell, 41, 2011
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