6E3Z

Structure of Bace-1 in complex with Ligand 8

Summary for 6E3Z

Entry DOI	10.2210/pdb6e3z/pdb
Descriptor	Beta-secretase 1, N-{3-[(2R,3R)-5-amino-3-methyl-2-(trifluoromethyl)-3,6-dihydro-2H-1,4-oxazin-3-yl]-4-fluorophenyl}-3,5-dichloropyridine-2-carboxamide (3 entities in total)
Functional Keywords	bace protease, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	3
Total formula weight	146194.30
Authors	Shaffer, P.L. (deposition date: 2018-07-16, release date: 2019-09-11, Last modification date: 2024-10-23)
Primary citation	Gijsen, H.J.M.,Lin, J.,Houpis, Y. Discovery and Chemical Development of JNJ-50138803, a Clinical Candidate BACE1 Inhibitor Acs Symp.Ser., 1307:-, 2020 Cited by DOI: 10.1021/bk-2018-1307.ch004 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.94 Å)

Structure validation