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PDB: 45910 results

5EGS
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BU of 5egs by Molmil
Human PRMT6 with bound fragment-type inhibitor
Descriptor: 2-[4-(phenylmethyl)piperidin-1-yl]ethanamine, Protein arginine N-methyltransferase 6, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Steuber, H, Egner, U, Kania, J, Wu, H, Brown, P.J.
Deposit date:2015-10-27
Release date:2016-02-03
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Discovery of a Potent Class I Protein Arginine Methyltransferase Fragment Inhibitor.
J.Med.Chem., 59, 2016
2WW5
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BU of 2ww5 by Molmil
3D-structure of the modular autolysin LytC from Streptococcus pneumoniae at 1.6 A resolution
Descriptor: 1,4-BETA-N-ACETYLMURAMIDASE, CHLORIDE ION, CHOLINE ION, ...
Authors:Perez-Dorado, I, Sanles, R, Hermoso, J.A, Gonzalez, A, Garcia, A, Garcia, P, Garcia, J.L, Menendez, M.
Deposit date:2009-10-21
Release date:2010-04-21
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.61 Å)
Cite:Insights Into Pneumococcal Fratricide from the Crystal Structures of the Modular Killing Factor Lytc.
Nat.Struct.Mol.Biol., 17, 2010
3I5K
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BU of 3i5k by Molmil
Crystal structure of the NS5B polymerase from Hepatitis C Virus (HCV) strain JFH1
Descriptor: PHOSPHATE ION, RNA-directed RNA polymerase
Authors:Simister, P.C, Schmitt, M, Lohmann, V, Bressanelli, S.
Deposit date:2009-07-05
Release date:2009-09-22
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural and functional analysis of hepatitis C virus strain JFH1 polymerase
J.Virol., 83, 2009
5EHC
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BU of 5ehc by Molmil
Co-crystal structure of eIF4E with nucleotide mimetic inhibitor.
Descriptor: 3-[[(2~{R},3~{S},4~{R},5~{R})-5-[2-azanyl-7-[(3-chlorophenyl)methyl]-6-oxidanylidene-1~{H}-purin-7-ium-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methylamino]-4-oxidanyl-cyclobut-3-ene-1,2-dione, Eukaryotic translation initiation factor 4 gamma 1, Eukaryotic translation initiation factor 4E
Authors:Nowicki, M.W, Walkinshaw, M.D, Fischer, P.M.
Deposit date:2015-10-28
Release date:2016-09-07
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Design of nucleotide-mimetic and non-nucleotide inhibitors of the translation initiation factor eIF4E: Synthesis, structural and functional characterisation.
Eur.J.Med.Chem., 124, 2016
5NUN
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BU of 5nun by Molmil
Engineered beta-lactoglobulin: variant F105L-L39A-M107F in complex with chlorpromazine (LG-LAF-CLP)
Descriptor: 3-(2-chloro-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-amine, Beta-lactoglobulin
Authors:Loch, J.I, Bonarek, P, Towrzydlo, M, Lazinskia, I, Szydlowska, J, Lewinski, K.
Deposit date:2017-04-30
Release date:2018-04-04
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:The engineered beta-lactoglobulin with complementarity to the chlorpromazine chiral conformers.
Int. J. Biol. Macromol., 114, 2018
4X3F
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BU of 4x3f by Molmil
Crystal structure of the intracellular domain of the M. tuberculosis Ser/Thr kinase PknA
Descriptor: Serine/threonine-protein kinase PknA
Authors:Wagner, T, Wehenkel, A, Alzari, P.M, Bellinzoni, M.
Deposit date:2014-11-28
Release date:2015-01-21
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:The crystal structure of the catalytic domain of the ser/thr kinase PknA from M. tuberculosis shows an Src-like autoinhibited conformation.
Proteins, 83, 2015
5NZS
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BU of 5nzs by Molmil
The structure of the COPI coat leaf in complex with the ArfGAP2 uncoating factor
Descriptor: ADP-ribosylation factor 1, ADP-ribosylation factor GTPase-activating protein 2, Coatomer subunit alpha, ...
Authors:Dodonova, S.O, Aderhold, P, Kopp, J, Ganeva, I, Roehling, S, Hagen, W.J.H, Sinning, I, Wieland, F, Briggs, J.A.G.
Deposit date:2017-05-15
Release date:2017-06-28
Last modified:2024-07-10
Method:ELECTRON MICROSCOPY (10.1 Å)
Cite:9 angstrom structure of the COPI coat reveals that the Arf1 GTPase occupies two contrasting molecular environments.
Elife, 6, 2017
5ULG
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BU of 5ulg by Molmil
Crystal structure of RPE65 in complex with MB-008 and palmitate
Descriptor: (3S)-3-({3-[(1R)-3-amino-1-hydroxypropyl]phenoxy}methyl)hexan-1-ol, FE (II) ION, PALMITIC ACID, ...
Authors:Kiser, P.D, Palczewski, K.
Deposit date:2017-01-24
Release date:2017-05-17
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Rational Tuning of Visual Cycle Modulator Pharmacodynamics.
J. Pharmacol. Exp. Ther., 362, 2017
1LGV
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BU of 1lgv by Molmil
Structure of a Human Bence-Jones Dimer Crystallized in U.S. Space Shuttle Mission STS-95: 100K
Descriptor: IMMUNOGLOBULIN LAMBDA LIGHT CHAIN
Authors:Terzyan, S.S, DeWitt, C.R, Ramsland, P.A, Bourne, P.C, Edmundson, A.B.
Deposit date:2002-04-16
Release date:2003-07-01
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Comparison of the three-dimensional structures of a human Bence-Jones dimer crystallized on Earth and aboard US Space Shuttle Mission STS-95
J.MOL.RECOG., 16, 2003
8VT3
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BU of 8vt3 by Molmil
cryo-EM structure of HMPV (MPV-2cREKR)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Prefusion of HMPV (MPV-2cREKR), ...
Authors:Yu, X, Langedijk, J.P.M.
Deposit date:2024-01-25
Release date:2024-07-31
Last modified:2024-08-07
Method:ELECTRON MICROSCOPY (3.33 Å)
Cite:Efficacious human metapneumovirus vaccine based on AI-guided engineering of a closed prefusion trimer.
Nat Commun, 15, 2024
1OXL
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BU of 1oxl by Molmil
INHIBITION OF PHOSPHOLIPASE A2 (PLA2) BY (2-CARBAMOYLMETHYL-5-PROPYL-OCTAHYDRO-INDOL-7-YL)-ACETIC ACID (INDOLE): CRYSTAL STRUCTURE OF THE COMPLEX FORMED BETWEEN PLA2 FROM RUSSELL'S VIPER AND INDOLE AT 1.8 RESOLUTION
Descriptor: (2-CARBAMOYLMETHYL-5-PROPYL-OCTAHYDRO-INDOL-7-YL)ACETIC ACID, CARBONATE ION, Phospholipase A2 VRV-PL-VIIIa, ...
Authors:Chandra, V, Balasubramanya, R, Kaur, P, Singh, T.P.
Deposit date:2003-04-02
Release date:2004-04-06
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of the complex of the secretory phospholipase A2 from Daboia russelli pulchella with an endogenic indole derivative, 2-carbamoylmethyl-5-propyl-octahydro-indol-7-yl-acetic acid at 1.8 A resolution.
Biochim.Biophys.Acta, 1752, 2005
5UNQ
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BU of 5unq by Molmil
Crystal Structure of Pt0534 Inactivated by 2-Oxo-3-pentynoate
Descriptor: Putative tautomerase
Authors:LeVieux, J, Baas, B.J, Zhang, Y.J, Whitman, C.P.
Deposit date:2017-01-31
Release date:2017-11-22
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.976 Å)
Cite:A global view of structure-function relationships in the tautomerase superfamily.
J. Biol. Chem., 293, 2018
1P4E
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BU of 1p4e by Molmil
Flpe W330F mutant-DNA Holliday Junction Complex
Descriptor: 33-MER, 5'-D(*TP*AP*AP*GP*TP*TP*CP*CP*TP*AP*TP*TP*C)-3', 5'-D(*TP*TP*TP*AP*AP*AP*AP*GP*AP*AP*TP*AP*GP*GP*AP*AP*CP*TP*TP*C)-3', ...
Authors:Rice, P.A, Chen, Y.
Deposit date:2003-04-23
Release date:2003-05-20
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The role of the conserved Trp330 in Flp-mediated recombination. Functional and structural analysis
J.Biol.Chem., 278, 2003
4WST
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BU of 4wst by Molmil
The crystal structure of hemagglutinin from A/Taiwan/1/2013 influenza virus
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin HA1 chain, Hemagglutinin HA2 chain
Authors:Yang, H, Carney, P.J, Chang, J, Villanueva, J.M, Stevens, J.
Deposit date:2014-10-28
Release date:2015-02-25
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure and receptor binding preferences of recombinant hemagglutinins from avian and human h6 and h10 influenza a virus subtypes.
J.Virol., 89, 2015
6NTI
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BU of 6nti by Molmil
Neutron/X-ray crystal structure of AAC-VIa bound to kanamycin b
Descriptor: (1R,2S,3S,4R,6S)-4,6-DIAMINO-3-[(3-AMINO-3-DEOXY-ALPHA-D-GLUCOPYRANOSYL)OXY]-2-HYDROXYCYCLOHEXYL 2,6-DIAMINO-2,6-DIDEOXY-ALPHA-D-GLUCOPYRANOSIDE, Aminoglycoside N(3)-acetyltransferase, MAGNESIUM ION
Authors:Cuneo, M.J, Kumar, P.
Deposit date:2019-01-29
Release date:2019-09-25
Last modified:2024-04-03
Method:NEUTRON DIFFRACTION (2.3 Å), X-RAY DIFFRACTION
Cite:Low-Barrier and Canonical Hydrogen Bonds Modulate Activity and Specificity of a Catalytic Triad.
Angew.Chem.Int.Ed.Engl., 58, 2019
5LUR
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BU of 5lur by Molmil
An avidin mutant
Descriptor: Avidin, CHLORIDE ION, PROGESTERONE
Authors:Agrawal, N, Lehtonen, S.I, Riihimaki, T.A, Kulomaa, M.S, Hytonen, V.P, Johnson, M.S, Airenne, T.T.
Deposit date:2016-09-09
Release date:2017-09-20
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:An avidin mutant
TO BE PUBLISHED
8WCH
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BU of 8wch by Molmil
Crystal structure of SAR11_0655 bound to a co-purified ligand, L-pyroglutamate
Descriptor: PYROGLUTAMIC ACID, Probable Leu/Ile/Val-binding protein, SODIUM ION
Authors:Clifton, B.E, Laurino, P.
Deposit date:2023-09-12
Release date:2024-07-17
Method:X-RAY DIFFRACTION (1.519 Å)
Cite:Crystal structure of SAR11_0655 bound to a co-purified ligand, L-pyroglutamate
To be published
4YXM
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BU of 4yxm by Molmil
Structure of Thermotoga maritima DisA D75N mutant with reaction product c-di-AMP
Descriptor: (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8 ]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide, (4S)-2-METHYL-2,4-PENTANEDIOL, DNA integrity scanning protein DisA
Authors:Mueller, M, Deimling, T, Hopfner, K.-P, Witte, G.
Deposit date:2015-03-23
Release date:2015-06-03
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural analysis of the diadenylate cyclase reaction of DNA-integrity scanning protein A (DisA) and its inhibition by 3'-dATP.
Biochem.J., 469, 2015
7LNW
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BU of 7lnw by Molmil
I146A mutant of the isopentenyl phosphate kinase from Candidatus methanomethylophilus alvus
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Isopentenyl phosphate kinase, [(~{Z})-5-[(azanylidene-$l^{4}-azanylidene)amino]-3-methyl-pent-2-enyl] dihydrogen phosphate
Authors:Thomas, L.M, Singh, S, Johnson, B.P.
Deposit date:2021-02-08
Release date:2021-12-22
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:Molecular Basis for the Substrate Promiscuity of Isopentenyl Phosphate Kinase from Candidatus methanomethylophilus alvus .
Acs Chem.Biol., 17, 2022
7LNX
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BU of 7lnx by Molmil
I146A mutant of the isopentenyl phosphate kinase from Candidatus methanomethylophilus alvus
Descriptor: (2E)-3-methylhept-2-en-1-yl dihydrogen phosphate, (2Z)-3-methylhept-2-en-1-yl trihydrogen diphosphate, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Thomas, L.M, Singh, S, Johnson, B.P.
Deposit date:2021-02-08
Release date:2021-12-22
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Molecular Basis for the Substrate Promiscuity of Isopentenyl Phosphate Kinase from Candidatus methanomethylophilus alvus .
Acs Chem.Biol., 17, 2022
1P5G
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BU of 1p5g by Molmil
Enzyme-ligand complex of P. aeruginosa PMM/PGM
Descriptor: 6-O-phosphono-alpha-D-glucopyranose, Phosphomannomutase, ZINC ION
Authors:Regni, C, Tipton, P.A, Beamer, L.J.
Deposit date:2003-04-26
Release date:2004-01-20
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.61 Å)
Cite:Structural basis of diverse substrate recognition by the enzyme PMM/PGM from P. aeruginosa.
Structure, 12, 2004
2GL1
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BU of 2gl1 by Molmil
NMR solution structure of Vigna radiata Defensin 2 (VrD2)
Descriptor: PDF1
Authors:Lin, K.F, Lee, T.R, Tsai, P.H, Hsu, M.P, Chen, C.S, Lyu, P.C.
Deposit date:2006-04-04
Release date:2007-04-03
Last modified:2022-03-09
Method:SOLUTION NMR
Cite:Structure-based protein engineering for alpha-amylase inhibitory activity of plant defensin.
Proteins, 68, 2007
5LIW
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BU of 5liw by Molmil
Crystal structure of human AKR1B10 complexed with NADP+ and the inhibitor MK319
Descriptor: 1,2-ETHANEDIOL, Aldo-keto reductase family 1 member B10, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Cousido-Siah, A, Ruiz, F.X, Mitschler, A, Fanfrlik, J, Kamlar, M, Vesely, J, Hobza, P, Podjarny, A.
Deposit date:2016-07-15
Release date:2016-07-27
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:IDD388 Polyhalogenated Derivatives as Probes for an Improved Structure-Based Selectivity of AKR1B10 Inhibitors.
Acs Chem.Biol., 11, 2016
5G3L
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BU of 5g3l by Molmil
ESCHERICHIA COLI HEAT LABILE ENTEROTOXIN TYPE IIB B-PENTAMER COMPLEXED WITH SIALYLATED SUGAR
Descriptor: HEAT-LABILE ENTEROTOXIN IIB, B CHAIN, N-acetyl-alpha-neuraminic acid, ...
Authors:Zalem, D, Benktander, J, Ribeiro, J.P, Varrot, A, Lebens, M, Imberty, A, Teneberg, S.
Deposit date:2016-04-29
Release date:2016-09-14
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Biochemical and Structural Characterization of the Novel Sialic Acid-Binding Site of Escherichia Coli Heat-Labile Enterotoxin Lt-Iib.
Biochem.J., 473, 2016
1H79
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BU of 1h79 by Molmil
STRUCTURAL BASIS FOR ALLOSTERIC SUBSTRATE SPECIFICITY REGULATION IN CLASS III RIBONUCLEOTIDE REDUCTASES: NRDD IN COMPLEX WITH DTTP
Descriptor: ANAEROBIC RIBONUCLEOTIDE-TRIPHOSPHATE REDUCTASE LARGE CHAIN, FE (II) ION, MAGNESIUM ION, ...
Authors:Larsson, K.-M, Andersson, J, Sjoeberg, B.-M, Nordlund, P, Logan, D.T.
Deposit date:2001-07-04
Release date:2002-03-28
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural Basis for Allosteric Substrate Specificty Regulation in Anaerobic Ribonucleotide Reductase
Structure, 9, 2001

223790

数据于2024-08-14公开中

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