4YXM

Structure of Thermotoga maritima DisA D75N mutant with reaction product c-di-AMP

Summary for 4YXM

• Entry DOI: 10.2210/pdb4yxm/pdb
• Related: 3c1y 3c1z 3c21 3c23 4yvz 4yxj
• Descriptor: DNA integrity scanning protein DisA, (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8 ]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide, (4S)-2-METHYL-2,4-PENTANEDIOL, ... (4 entities in total)
• Functional Keywords: dna binding protein, c-di-amp synthesis, dac domain, inhibitor, pre-reaction state, transferase
• Biological source: Thermotoga maritima
• Total number of polymer chains: 2
• Total formula weight: 86302.59

Authors

Mueller, M.,Deimling, T.,Hopfner, K.-P.,Witte, G. (deposition date: 2015-03-23, release date: 2015-06-03, Last modification date: 2024-01-10)

• Primary citation: Muller, M.,Deimling, T.,Hopfner, K.P.,Witte, G.; Structural analysis of the diadenylate cyclase reaction of DNA-integrity scanning protein A (DisA) and its inhibition by 3'-dATP.; Biochem.J., 469:367-374, 2015; PubMed: 26014055; DOI: 10.1042/BJ20150373

Experimental method

X-RAY DIFFRACTION (2.25 Å)