1OXL

INHIBITION OF PHOSPHOLIPASE A2 (PLA2) BY (2-CARBAMOYLMETHYL-5-PROPYL-OCTAHYDRO-INDOL-7-YL)-ACETIC ACID (INDOLE): CRYSTAL STRUCTURE OF THE COMPLEX FORMED BETWEEN PLA2 FROM RUSSELL'S VIPER AND INDOLE AT 1.8 RESOLUTION

Summary for 1OXL

• Entry DOI: 10.2210/pdb1oxl/pdb
• Related: 1CL5 1FB2
• Descriptor: Phospholipase A2 VRV-PL-VIIIa, (2-CARBAMOYLMETHYL-5-PROPYL-OCTAHYDRO-INDOL-7-YL)ACETIC ACID, CARBONATE ION, ... (5 entities in total)
• Functional Keywords: phospholipase a2, indole derivative, inhibition, hydrolase
• Biological source: Daboia russellii russellii
• Cellular location: Secreted : P59071
• Total number of polymer chains: 2
• Total formula weight: 27749.93

Authors

Chandra, V.,Balasubramanya, R.,Kaur, P.,Singh, T.P. (deposition date: 2003-04-02, release date: 2004-04-06, Last modification date: 2023-08-16)

• Primary citation: Balasubramanya, R.,Chandra, V.,Kaur, P.,Singh, T.P.; Crystal structure of the complex of the secretory phospholipase A2 from Daboia russelli pulchella with an endogenic indole derivative, 2-carbamoylmethyl-5-propyl-octahydro-indol-7-yl-acetic acid at 1.8 A resolution.; Biochim.Biophys.Acta, 1752:177-185, 2005; PubMed: 16122995; DOI: 10.1016/j.bbapap.2005.07.020

Experimental method

X-RAY DIFFRACTION (1.8 Å)