4LOS
 
 | | C1s CUB2-CCP1 | | Descriptor: | CALCIUM ION, Complement C1s subcomponent heavy chain | | Authors: | Wallis, R, Venkatraman Girija, U, Moody, P.C.E, Marshall, J.E, Gingras, A.R. | | Deposit date: | 2013-07-13 | | Release date: | 2013-08-07 | | Last modified: | 2013-09-04 | | Method: | X-RAY DIFFRACTION (1.996 Å) | | Cite: | Structural basis of the C1q/C1s interaction and its central role in assembly of the C1 complex of complement activation.
Proc.Natl.Acad.Sci.USA, 110, 2013
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3QV7
 | | Crystal structure of Leishmania mexicana pyruvate kinase(LmPYK)in complex with ponceau S and acid blue 25. | | Descriptor: | 3-hydroxy-4-[(E)-{2-sulfo-4-[(E)-(4-sulfophenyl)diazenyl]phenyl}diazenyl]naphthalene-2,7-disulfonic acid, 9,10-dioxo-4-(phenylamino)-9,10-dihydroanthracene-2-sulfonic acid, POTASSIUM ION, ... | | Authors: | Morgan, H.P, Auld, D.S, McNae, I.W, Nowicki, M.W, Michels, P.A.M, Fothergill-Gilmore, L.A, Walkinshaw, M.D. | | Deposit date: | 2011-02-25 | | Release date: | 2011-06-29 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | The trypanocidal drug suramin and other trypan blue mimetics are inhibitors of pyruvate kinases and bind to the adenosine site.
J.Biol.Chem., 286, 2011
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5ZRO
 | | M. smegmatis antimutator protein MutT2 in complex with 5mdCTP | | Descriptor: | 1,2-ETHANEDIOL, 2'-DEOXY-5-METHYLCYTIDINE 5'-(TETRAHYDROGEN TRIPHOSPHATE), Putative mutator protein MutT2/NUDIX hydrolase | | Authors: | Singh, A, Arif, S.M, Sang, P.B, Varshney, U, Vijayan, M. | | Deposit date: | 2018-04-24 | | Release date: | 2019-04-24 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.41 Å) | | Cite: | Structural insights into the specificity and catalytic mechanism of mycobacterial nucleotide pool sanitizing enzyme MutT2.
J.Struct.Biol., 204, 2018
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5ZVA
 | | APOBEC3F Chimeric Catalytic Domain in Complex with DNA(dC9) | | Descriptor: | APEBEC3F/ssDNA-C9, CACODYLATE ION, DNA (5'-D(*AP*TP*TP*TP*TP*CP*AP*AP*CP*T)-3'), ... | | Authors: | Cheng, C, Zhang, T.L, Wang, C.X, Lan, W.X, Ding, J.P, Cao, C.Y. | | Deposit date: | 2018-05-09 | | Release date: | 2018-11-21 | | Last modified: | 2018-11-28 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Crystal Structure of Cytidine Deaminase Human APOBEC3F Chimeric Catalytic Domain in Complex with DNA
Chin.J.Chem., 36, 2018
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4LQD
 | | The crystal structures of the Brucella protein TcpB and the TLR adaptor protein TIRAP show structural differences in microbial TIR mimicry | | Descriptor: | GLYCEROL, Toll/interleukin-1 receptor domain-containing adapter protein | | Authors: | Snyder, G.A, Smith, P, Jiang, J, Xiao, T.S. | | Deposit date: | 2013-07-17 | | Release date: | 2013-12-04 | | Last modified: | 2014-04-09 | | Method: | X-RAY DIFFRACTION (2.451 Å) | | Cite: | Crystal structures of the Toll/Interleukin-1 receptor (TIR) domains from the Brucella protein TcpB and host adaptor TIRAP reveal mechanisms of molecular mimicry.
J.Biol.Chem., 289, 2014
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8SF6
 | | Promiscuous amino acid gamma synthase from Caldicellulosiruptor hydrothermalis in closed conformation | | Descriptor: | 2-(2-ETHOXYETHOXY)ETHANOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-{2-[2-2-(METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, ... | | Authors: | Buller, A.R, Zmich, A.P, Bingman, C.A. | | Deposit date: | 2023-04-10 | | Release date: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (1.702 Å) | | Cite: | Multiplexed Assessment of Promiscuous Non-Canonical Amino Acid Synthase Activity in a Pyridoxal Phosphate-Dependent Protein Family.
Acs Catalysis, 13, 2023
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6M5U
 | | The coordinates of the monomeric terminase complex in the presence of the ADP-BeF3 | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, ... | | Authors: | Yang, Y.X, Yang, P, Wang, N, Zhu, L, Zhou, Z.H, Rao, Z.H, Wang, X.X. | | Deposit date: | 2020-03-11 | | Release date: | 2020-10-28 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Architecture of the herpesvirus genome-packaging complex and implications for DNA translocation.
Protein Cell, 11, 2020
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2ZBJ
 | | Crystal structure of Dioclea rostrata lectin | | Descriptor: | CALCIUM ION, Lectin alpha chain, MANGANESE (II) ION, ... | | Authors: | de Oliveira, T.M, Delatorre, P, da Rocha, B.A.M, de Sousa, E.P, Nascimento, K.S, Bezerra, G.A, Moura, T.R, Benevides, R.G, Bezerra, E.H.S, Moreno, F.B.M.B, Freire, V.N, de Azevedo Jr, W.F, Cavada, B.S. | | Deposit date: | 2007-10-22 | | Release date: | 2008-08-19 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Crystal structure of Dioclea rostrata lectin: Insights into understanding the pH-dependent dimer-tetramer equilibrium and the structural basis for carbohydrate recognition in Diocleinae lectins
J.Struct.Biol., 164, 2008
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4LTG
 | | Dehydration/Rehydration of a Nucleic Acid system containing a Polypyridyl Ruthenium Complex at 74% relative humidity (2/7) | | Descriptor: | BARIUM ION, CHLORIDE ION, DNA, ... | | Authors: | Hall, J.P, Sanchez-Weatherby, J, Cardin, C.J. | | Deposit date: | 2013-07-23 | | Release date: | 2014-09-24 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.18 Å) | | Cite: | Controlled Dehydration of a Ruthenium Complex-DNA Crystal Induces Reversible DNA Kinking.
J.Am.Chem.Soc., 136, 2014
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7VT7
 | | Crystal structure of CBM deleted MtGlu5 in complex with CBI | | Descriptor: | Endoglucanase H, GLYCEROL, TRYPTOPHAN, ... | | Authors: | Ye, T.J, Ko, P.T, Huang, K.F, Wu, S.H. | | Deposit date: | 2021-10-28 | | Release date: | 2022-09-07 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.53 Å) | | Cite: | Synergic action of an inserted carbohydrate-binding module in a glycoside hydrolase family 5 endoglucanase.
Acta Crystallogr D Struct Biol, 78, 2022
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3NFI
 | | Crystal structure of tandem winged helix domain of RNA polymerase I subunit A49 | | Descriptor: | 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, DNA-directed RNA polymerase I subunit RPA49 | | Authors: | Geiger, S.R, Lorenzen, K, Schreieck, A, Hanecker, P, Kostrewa, D, Heck, A.J.R, Cramer, P. | | Deposit date: | 2010-06-10 | | Release date: | 2010-09-08 | | Last modified: | 2015-03-25 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | RNA Polymerase I Contains a TFIIF-Related DNA-Binding Subcomplex.
Mol.Cell, 39, 2010
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6MB4
 | | Binary (sisomicin) structure of AAC-IIIb | | Descriptor: | (1S,2S,3R,4S,6R)-4,6-diamino-3-{[(2S,3R)-3-amino-6-(aminomethyl)-3,4-dihydro-2H-pyran-2-yl]oxy}-2-hydroxycyclohexyl 3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranoside, Aac(3)-IIIb protein | | Authors: | Cuneo, M.J, Kumar, P. | | Deposit date: | 2018-08-29 | | Release date: | 2018-11-07 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.302 Å) | | Cite: | Encoding of Promiscuity in an Aminoglycoside Acetyltransferase.
J. Med. Chem., 61, 2018
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5EB6
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2IVO
 | | Structure of UP1 protein | | Descriptor: | TUNGSTATE(VI)ION, UP1 | | Authors: | Hecker, A, Leulliot, N, Graille, M, Dorlet, P, Quevillon-Cheruel, S, Ulryck, N, Van Tilbeurgh, H, Forterre, P. | | Deposit date: | 2006-06-14 | | Release date: | 2007-07-31 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | An Archaeal Orthologue of the Universal Protein Kae1 is an Iron Metalloprotein which Exhibits Atypical DNA-Binding Properties and Apurinic-Endonuclease Activity in Vitro.
Nucleic Acids Res., 35, 2007
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8CEX
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3NG1
 | | N AND GTPASE DOMAINS OF THE SIGNAL SEQUENCE RECOGNITION PROTEIN FFH FROM THERMUS AQUATICUS | | Descriptor: | 1,2-ETHANEDIOL, CADMIUM ION, SIGNAL SEQUENCE RECOGNITION PROTEIN FFH, ... | | Authors: | Freymann, D.M, Stroud, R.M, Walter, P. | | Deposit date: | 1998-09-13 | | Release date: | 1999-07-30 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Functional changes in the structure of the SRP GTPase on binding GDP and Mg2+GDP.
Nat.Struct.Biol., 6, 1999
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3HII
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6MB6
 | | AAC-IIIb binary with CoASH | | Descriptor: | Aac(3)-IIIb protein, COENZYME A, MALONATE ION | | Authors: | Cuneo, M.J, Kumar, P. | | Deposit date: | 2018-08-29 | | Release date: | 2018-11-07 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Encoding of Promiscuity in an Aminoglycoside Acetyltransferase.
J. Med. Chem., 61, 2018
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6EIC
 | | Crystal structure of Rv0183, a Monoglyceride Lipase from Mycobacterium Tuberculosis | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, Mycobacterium Tuberculosis Monoglyceride Lipase, NITRATE ION, ... | | Authors: | Aschauer, P, Pavkov-Keller, T, Oberer, M. | | Deposit date: | 2017-09-19 | | Release date: | 2018-06-27 | | Last modified: | 2024-06-19 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | The crystal structure of monoacylglycerol lipase from M. tuberculosis reveals the basis for specific inhibition.
Sci Rep, 8, 2018
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5DT3
 | | Aurora A Kinase in Complex with ATP in Space Group P6122 | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Aurora kinase A, MAGNESIUM ION, ... | | Authors: | Janecek, M, Rossmann, M, Sharma, P, Emery, A, McKenzie, G.J, Huggins, D.J, Stockwell, S, Stokes, J.A, Almeida, E.G, Hardwick, B, Narvaez, A.J, Hyvonen, M, Spring, D.R, Venkitaraman, A.R. | | Deposit date: | 2015-09-17 | | Release date: | 2016-07-20 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.33 Å) | | Cite: | Allosteric modulation of AURKA kinase activity by a small-molecule inhibitor of its protein-protein interaction with TPX2.
Sci Rep, 6, 2016
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4PNR
 | | Crystal Structure of human Tankyrase 2 in complex with TIQ-A. | | Descriptor: | 4H-thieno[2,3-c]isoquinolin-5-one, ETHANOL, GLYCEROL, ... | | Authors: | Qiu, W, Lam, R, Romanov, V, Gordon, R, Gebremeskel, S, Vodsedalek, J, Thompson, C, Beletskaya, I, Battaile, K.P, Pai, E.F, Chirgadze, N.Y. | | Deposit date: | 2014-05-24 | | Release date: | 2014-10-15 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (1.71 Å) | | Cite: | Insights into the binding of PARP inhibitors to the catalytic domain of human tankyrase-2.
Acta Crystallogr.,Sect.D, 70, 2014
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4HI9
 | | 1.2 structure of integrin-linked kinase ankyrin repeat domain in complex with PINCH1 LIM1 domain collected at wavelength 0.91974 | | Descriptor: | IODIDE ION, Integrin-linked protein kinase, LIM and senescent cell antigen-like-containing domain protein 1, ... | | Authors: | Stiegler, A.L, Jakoncic, J, Stojanoff, V, Chiswell, B.P, Calderwood, D.A, Boggon, T.J. | | Deposit date: | 2012-10-11 | | Release date: | 2013-12-11 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.203 Å) | | Cite: | 1.2 structure of integrin-linked kinase ankyrin repeat domain in complex with PINCH1 LIM1 domain collected at wavelength 0.91974
To be Published
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6UGH
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8CEY
 | | Structure of the mouse 8-oxoguanine DNA Glycosylase mOGG1 in complex with ligand TH11233 | | Descriptor: | N-glycosylase/DNA lyase, NICKEL (II) ION, ~{N}-(3,3-dimethylcyclobutyl)imidazo[5,1-b][1,3]thiazole-3-carboxamide | | Authors: | Kosenina, S, Scaletti, E.R, Stenmark, P. | | Deposit date: | 2023-02-02 | | Release date: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Structure of the mouse 8-oxoguanine DNA Glycosylase mOGG1 in complex with ligand TH11233
To Be Published
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3HRZ
 | | Cobra Venom Factor (CVF) in complex with human factor B | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cobra venom factor, ... | | Authors: | Janssen, B.J.C, Gomes, L, Koning, R.I, Svergun, D.I, Koster, A.J, Fritzinger, D.C, Vogel, C.-W, Gros, P. | | Deposit date: | 2009-06-10 | | Release date: | 2009-07-07 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Insights into complement convertase formation based on the structure of the factor B-cobra venom factor complex
Embo J., 28, 2009
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