7R4N
| Structure of human hydroxyacid oxidase 1 bound with 5-bromo-N-methyl-1H-indazole-3-carboxamide | 分子名称: | 1,2-ETHANEDIOL, 5-bromanyl-N-methyl-1H-indazole-3-carboxamide, FLAVIN MONONUCLEOTIDE, ... | 著者 | Mackinnon, S, Bezerra, G.A, Krojer, T, Bradley, A.R, Talon, R, Brandeo-Neto, J, Douangamath, A, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Oppermann, U, Brennan, P.E, Yue, W.W. | 登録日 | 2022-02-08 | 公開日 | 2022-03-02 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structure of human hydroxyacid oxidase 1 bound with 5-bromo-N-methyl-1H-indazole-3-carboxamide To Be Published
|
|
6NWD
| X-ray Crystallographic structure of Gloeobacter rhodopsin | 分子名称: | 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, DECANE, DODECANE, ... | 著者 | Ernst, O.P, Morizumi, T, Ou, W.L. | 登録日 | 2019-02-06 | 公開日 | 2019-08-14 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | X-ray Crystallographic Structure and Oligomerization of Gloeobacter Rhodopsin. Sci Rep, 9, 2019
|
|
7RHQ
| Cryo-EM structure of Xenopus Patched-1 in complex with GAS1 and Sonic Hedgehog | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Huang, P, Lian, T, Wierbowski, B, Garcia-Linares, S, Jiang, J, Salic, A. | 登録日 | 2021-07-18 | 公開日 | 2022-03-02 | 最終更新日 | 2022-03-23 | 実験手法 | ELECTRON MICROSCOPY (3.53 Å) | 主引用文献 | Structural basis for catalyzed assembly of the Sonic hedgehog-Patched1 signaling complex. Dev.Cell, 57, 2022
|
|
7R70
| Crystal Structure of the UbArk2C fusion protein | 分子名称: | GLYCEROL, Ubiquitin,E3 ubiquitin-protein ligase RNF165, ZINC ION | 著者 | Paluda, A, Middleton, A.J, Mace, P.D, Day, C.L. | 登録日 | 2021-06-24 | 公開日 | 2022-03-09 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.499 Å) | 主引用文献 | Ubiquitin and a charged loop regulate the ubiquitin E3 ligase activity of Ark2C. Nat Commun, 13, 2022
|
|
6NWT
| RORgamma Ligand Binding Domain | 分子名称: | 1,1,1,3,3,3-hexafluoro-2-[2-fluoro-4'-({4-[(pyridin-4-yl)methyl]piperazin-1-yl}methyl)[1,1'-biphenyl]-4-yl]propan-2-ol, Nuclear receptor ROR-gamma | 著者 | Strutzenberg, T.S, Park, H, Griffin, P.R. | 登録日 | 2019-02-07 | 公開日 | 2019-07-10 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | HDX-MS reveals structural determinants for ROR gamma hyperactivation by synthetic agonists. Elife, 8, 2019
|
|
7R71
| Crystal Structure of the UbArk2C-UbcH5b~Ub complex | 分子名称: | Ubiquitin, Ubiquitin,E3 ubiquitin-protein ligase RNF165, Ubiquitin-conjugating enzyme E2 D2, ... | 著者 | Paluda, A, Middleton, A.J, Mace, P.D, Day, C.L. | 登録日 | 2021-06-24 | 公開日 | 2022-03-09 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Ubiquitin and a charged loop regulate the ubiquitin E3 ligase activity of Ark2C. Nat Commun, 13, 2022
|
|
8PM6
| Human bile salt export pump (BSEP) in complex with inhibitor GBM in nanodiscs | 分子名称: | 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, Bile salt export pump, CHOLESTEROL | 著者 | Liu, H, Irobalieva, R.N, Kowal, J, Ni, D, Nosol, K, Bang-Sorensen, R, Lancien, L, Stahlberg, H, Stieger, B, Locher, K.P. | 登録日 | 2023-06-28 | 公開日 | 2023-11-22 | 実験手法 | ELECTRON MICROSCOPY (3.22 Å) | 主引用文献 | Structural basis of bile salt extrusion and small-molecule inhibition in human BSEP. Nat Commun, 14, 2023
|
|
6NXW
| Crystal structure of Arabidopsis thaliana cytosolic triosephosphate isomerase C218S mutant | 分子名称: | Triosephosphate isomerase, cytosolic | 著者 | Jimenez-Sandoval, P, Diaz-Quezada, C, Torres-Larios, A, Brieba, L.G. | 登録日 | 2019-02-10 | 公開日 | 2020-02-19 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Structural basis for the modulation of plant cytosolic triosephosphate isomerase activity by mimicry of redox-based modifications. Plant J., 99, 2019
|
|
5YY5
| Structural definition of a unique neutralization epitope on the receptor-binding domain of MERS-CoV spike glycoprotein | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain, Light chain, ... | 著者 | Zhang, S, Wang, P, Zhou, P, Wang, X, Zhang, L. | 登録日 | 2017-12-08 | 公開日 | 2018-08-01 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural Definition of a Unique Neutralization Epitope on the Receptor-Binding Domain of MERS-CoV Spike Glycoprotein Cell Rep, 24, 2018
|
|
8QKK
| Cryo-EM structure of MmpL3 from Mycobacterium smegmatis reconstituted into peptidiscs | 分子名称: | Trehalose monomycolate exporter MmpL3 | 著者 | Couston, J, Guo, Z, Wang, K, Gourdon, P.E, Blaise, M. | 登録日 | 2023-09-15 | 公開日 | 2023-11-15 | 最終更新日 | 2023-12-13 | 実験手法 | ELECTRON MICROSCOPY (3.23 Å) | 主引用文献 | Cryo-EM structure of the trehalose monomycolate transporter, MmpL3, reconstituted into peptidiscs. Curr Res Struct Biol, 6, 2023
|
|
5ZNC
| |
7B5P
| AcrB in cycloalkane amphipol | 分子名称: | Efflux pump membrane transporter | 著者 | Higgins, A.J, Flynn, A.J, Muench, S.P. | 登録日 | 2020-12-05 | 公開日 | 2021-12-08 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Cycloalkane-modified amphiphilic polymers provide direct extraction of membrane proteins for CryoEM analysis. Commun Biol, 4, 2021
|
|
3K22
| Glucocorticoid Receptor with Bound alaninamide 10 with TIF2 peptide | 分子名称: | Glucocorticoid receptor, N-[(1R)-2-amino-1-methyl-2-oxoethyl]-3-(6-methyl-4-{[3,3,3-trifluoro-2-hydroxy-2-(trifluoromethyl)propyl]amino}-1H-indazol-1-yl)benzamide, Transcriptional Intermediary Factor 2, ... | 著者 | Biggadike, K.B, McLay, I.M, Madauss, K.P, Williams, S.P, Bledsoe, R.K. | 登録日 | 2009-09-29 | 公開日 | 2010-08-11 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Design and x-ray crystal structures of high-potency nonsteroidal glucocorticoid agonists exploiting a novel binding site on the receptor. Proc.Natl.Acad.Sci.USA, 106, 2009
|
|
6OJW
| Crystal structure of Sphingomonas paucimobilis TMY1009 holo-LsdA | 分子名称: | FE (III) ION, GLYCEROL, Lignostilbene-alpha,beta-dioxygenase isozyme I, ... | 著者 | Kuatsjah, E, Verstraete, M.M, Kobylarz, M.J, Liu, A.K.N, Murphy, M.E.P, Eltis, L.D. | 登録日 | 2019-04-12 | 公開日 | 2019-07-24 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Identification of functionally important residues and structural features in a bacterial lignostilbene dioxygenase. J.Biol.Chem., 294, 2019
|
|
1OAO
| NiZn[Fe4S4] and NiNi[Fe4S4] clusters in closed and open alpha subunits of acetyl-CoA synthase/carbon monoxide dehydrogenase | 分子名称: | ACETATE ION, BICARBONATE ION, CARBON MONOXIDE DEHYDROGENASE/ACETYL-COA SYNTHASE SUBUNIT ALPHA, ... | 著者 | Darnault, C, Volbeda, A, Kim, E.J, Legrand, P, Vernede, X, Lindahl, P.A, Fontecilla-Camps, J.C. | 登録日 | 2003-01-20 | 公開日 | 2003-04-11 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Ni-Zn-[Fe4-S4] and Ni-Ni-[Fe4-S4] Clusters in Closed and Open Alpha Subunits of Acetyl-Coa Synthase/Carbon Monoxide Dehydrogenase Nat.Struct.Biol., 10, 2003
|
|
8PMJ
| Vanadate-trapped BSEP in nanodiscs | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Bile salt export pump, ... | 著者 | Liu, H, Irobalieva, R.N, Kowal, J, Ni, D, Nosol, K, Bang-Sorensen, R, Lancien, L, Stahlberg, H, Stieger, B, Locher, K.P. | 登録日 | 2023-06-28 | 公開日 | 2023-11-29 | 実験手法 | ELECTRON MICROSCOPY (2.81 Å) | 主引用文献 | Structural basis of bile salt extrusion and small-molecule inhibition in human BSEP. Nat Commun, 14, 2023
|
|
3J9B
| Electron cryo-microscopy of an RNA polymerase | 分子名称: | Polymerase, Polymerase basic protein 2, RNA (5'-R(*UP*UP*UP*UP*UP*A)-3'), ... | 著者 | Chang, S.H, Sun, D.P, Liang, H.H, Wang, J, Li, J, Guo, L, Wang, X.L, Guan, C.C, Boruah, B.M, Yuan, L.M, Feng, F, Yang, M.R, Wojdyla, J, Wang, J.W, Wang, M.T, Wang, H.W, Liu, Y.F. | 登録日 | 2014-12-16 | 公開日 | 2015-02-18 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | 主引用文献 | Cryo-EM Structure of Influenza Virus RNA Polymerase Complex at 4.3 angstrom Resolution. Mol.Cell, 2015
|
|
7LHS
| |
6O5D
| PYOCHELIN | 分子名称: | GLYCEROL, Neutrophil gelatinase-associated lipocalin, SULFATE ION | 著者 | Rupert, P.B, Strong, R.K, Clifton, M.C, Edwards, T.E, Seattle Structural Genomics Center for Infectious Disease (SSGCID) | 登録日 | 2019-03-01 | 公開日 | 2019-09-11 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Parsing the functional specificity of Siderocalin/Lipocalin 2/NGAL for siderophores and related small-molecule ligands. J Struct Biol X, 2, 2019
|
|
3N3M
| |
7MC1
| Solution structure of Miz-1 Zinc finger 10 | 分子名称: | Isoform 2 of Zinc finger and BTB domain-containing protein 17, ZINC ION | 著者 | Boisvert, O, Lavigne, P. | 登録日 | 2021-04-01 | 公開日 | 2021-04-28 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Zinc Fingers 10 and 11 of Miz-1 undergo conformational exchange to achieve specific DNA binding. Structure, 30, 2022
|
|
4NBT
| Crystal structure of FabG from Acholeplasma laidlawii | 分子名称: | 3-oxoacyl-[acyl-carrier-protein] reductase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | 著者 | Pereira, J.H, Mcandrew, R.P, Javidpour, P, Beller, H.R, Adams, P.D. | 登録日 | 2013-10-23 | 公開日 | 2013-12-04 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.48 Å) | 主引用文献 | Biochemical and Structural Studies of NADH-Dependent FabG Used To Increase the Bacterial Production of Fatty Acids under Anaerobic Conditions. Appl.Environ.Microbiol., 80, 2014
|
|
8PMD
| Nucleotide-bound BSEP in nanodiscs | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Bile salt export pump, MAGNESIUM ION | 著者 | Liu, H, Irobalieva, R.N, Kowal, J, Ni, D, Nosol, K, Bang-Sorensen, R, Lancien, L, Stahlberg, H, Stieger, B, Locher, K.P. | 登録日 | 2023-06-28 | 公開日 | 2023-11-22 | 実験手法 | ELECTRON MICROSCOPY (2.95 Å) | 主引用文献 | Structural basis of bile salt extrusion and small-molecule inhibition in human BSEP. Nat Commun, 14, 2023
|
|
7MC2
| |
7Y39
| Ubiquitin-like domain of human ZFAND1 | 分子名称: | AN1-type zinc finger protein 1 | 著者 | Lai, C.H, Ko, K.T, Fan, P.J, Yu, T.A, Chang, C.F, Draczkowski, P, Hsu, S.T.D. | 登録日 | 2022-06-10 | 公開日 | 2022-08-10 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | 主引用文献 | Structural Insight into ZFAND1 and p97 Interaction To Be Published
|
|