7O67
 
 | | Crystal structure of human mitochondrial ferritin (hMTF) Fe(II)-loaded for 15 minutes showing either a dioxygen or a superoxide anion coordinated to iron ions in the ferroxidase site | | 分子名称: | CHLORIDE ION, FE (II) ION, Ferritin, ... | | 著者 | Pozzi, C, Ciambellotti, S, Tassone, G, Turano, P, Mangani, S. | | 登録日 | 2021-04-09 | | 公開日 | 2021-10-13 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | | 主引用文献 | Iron Binding in the Ferroxidase Site of Human Mitochondrial Ferritin.
Chemistry, 27, 2021
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9FMD
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9BLN
 | | The structure of human Pdcd4 bound to the 40S-eIF4A-eIF3-eIF1 complex | | 分子名称: | 40S ribosomal protein S14, ACETIC ACID, Eukaryotic initiation factor 4A-I, ... | | 著者 | Brito Querido, J, Sokabe, M, Diaz-Lopez, I, Gordiyenko, Y, Zuber, P, Yifei, D, Albacete-Albacete, L, Ramakrishnan, V, S Fraser, C. | | 登録日 | 2024-04-30 | | 公開日 | 2024-09-04 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Human tumor suppressor protein Pdcd4 binds at the mRNA entry channel in the 40S small ribosomal subunit.
Nat Commun, 15, 2024
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6NBA
 | | Crystal structure of Human Cystathionine gamma lyase with S-3-Carboxpropyl-L-Cysteine | | 分子名称: | 2-[({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)AMINO]ACRYLIC ACID, Cystathionine gamma-lyase | | 著者 | Kim, H, Yadav, P.K, Banerjee, R, Cho, U.-S. | | 登録日 | 2018-12-06 | | 公開日 | 2019-06-12 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.495 Å) | | 主引用文献 | S-3-Carboxypropyl-l-cysteine specifically inhibits cystathionine gamma-lyase-dependent hydrogen sulfide synthesis.
J.Biol.Chem., 294, 2019
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1Y4G
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3N1N
 | | Crystal structure of the complex of type I ribosome inactivating protein with guanine at 2.2A resolution | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GUANINE, Ribosome inactivating protein | | 著者 | Kushwaha, G.S, Singh, N, Sinha, M, Kaur, P, Betzel, C, Sharma, S, Singh, T.P. | | 登録日 | 2010-05-16 | | 公開日 | 2010-07-14 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.23 Å) | | 主引用文献 | Crystal structures of a type-1 ribosome inactivating protein from Momordica balsamina in the bound and unbound states
Biochim.Biophys.Acta, 1824, 2012
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8WIJ
 | | Crystal structure of E. coli ThrS catalytic domain mutant L489M in complex with Obafluorin | | 分子名称: | N-(2,3-dihydroxybenzoyl)-4-(4-nitrophenyl)-L-threonine, Threonine--tRNA ligase, ZINC ION | | 著者 | Qiao, H, Wang, Z, Wang, J, Fang, P. | | 登録日 | 2023-09-24 | | 公開日 | 2024-07-24 | | 実験手法 | X-RAY DIFFRACTION (3.08 Å) | | 主引用文献 | Specific glycine-dependent enzyme motion determines the potency of conformation selective inhibitors of threonyl-tRNA synthetase.
Commun Biol, 7, 2024
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4MBR
 | | 3.65 Angstrom Crystal Structure of Serine-rich Repeat Protein (Srr2) from Streptococcus agalactiae | | 分子名称: | Serine-rich repeat protein 2 | | 著者 | Minasov, G, Shuvalova, L, Dubrovska, I, Winsor, J, Seo, H.S, Seepersaud, R, Doran, K.S, Iverson, T.M, Sullam, P.M, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) | | 登録日 | 2013-08-19 | | 公開日 | 2013-11-06 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (3.65 Å) | | 主引用文献 | Characterization of Fibrinogen Binding by Glycoproteins Srr1 and Srr2 of Streptococcus agalactiae.
J.Biol.Chem., 288, 2013
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4MC6
 | | HIV protease in complex with SA499 | | 分子名称: | 1,2-ETHANEDIOL, 1-tert-butyl-3-{(2S,3R)-4-[(4R)-7-fluoro-1,1-dioxido-4-(propan-2-yl)-4,5-dihydro-1,2-benzothiazepin-2(3H)-yl]-3-hydroxy-1-phenylbutan-2-yl}urea, CHLORIDE ION, ... | | 著者 | Ganguly, A.K, Alluri, S.S, Wang, C, Antropow, A, White, A, Caroccia, D, Biswas, D, Kang, E, Zhang, L, Carroll, S.S, Burlein, C, Munshi, V, Orth, P, Strickland, C. | | 登録日 | 2013-08-21 | | 公開日 | 2014-04-02 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.31 Å) | | 主引用文献 | Structural Optimization of Cyclic Sulfonamide based Novel HIV-1 Protease Inhibitors to Pico Molar Affinities guided by X-ray Crystallographic Analysis
Tetrahedron, 2014
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6NIY
 | | A high-resolution cryo-electron microscopy structure of a calcitonin receptor-heterotrimeric Gs protein complex | | 分子名称: | Calcitonin, Calcitonin receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | dal Maso, E, Glukhova, A, Zhu, Y, Garcia-Nafria, J, Tate, C.G, Atanasio, S, Reynolds, C.A, Ramirez-Aportela, E, Carazo, J.-M, Hick, C.A, Furness, S.G.B, Hay, D.L, Liang, Y.-L, Miller, L.J, Christopoulos, A, Wang, M.-W, Wootten, D, Sexton, P.M. | | 登録日 | 2019-01-02 | | 公開日 | 2019-01-23 | | 最終更新日 | 2020-04-08 | | 実験手法 | ELECTRON MICROSCOPY (3.34 Å) | | 主引用文献 | The Molecular Control of Calcitonin Receptor Signaling.
Acs Pharmacol Transl Sci, 2, 2019
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4M5Z
 | | Crystal structure of broadly neutralizing antibody 5J8 bound to 2009 pandemic influenza hemagglutinin, HA1 subunit | | 分子名称: | Fab 5J8 heavy chain, Fab 5J8 light chain, Hemagglutinin HA1 chain | | 著者 | Hong, M, Lee, P.S, Wilson, I.A. | | 登録日 | 2013-08-08 | | 公開日 | 2013-09-25 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Antibody Recognition of the Pandemic H1N1 Influenza Virus Hemagglutinin Receptor Binding Site.
J.Virol., 87, 2013
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1YAD
 | | Structure of TenI from Bacillus subtilis | | 分子名称: | Regulatory protein tenI, SULFATE ION, TRIS-HYDROXYMETHYL-METHYL-AMMONIUM | | 著者 | Toms, A.V, Haas, A.L, Park, J.-H, Begley, T.P, Ealick, S.E. | | 登録日 | 2004-12-17 | | 公開日 | 2005-02-22 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structural characterization of the regulatory proteins TenA and TenI from Bacillus subtilis and identification of TenA as a thiaminase II.
Biochemistry, 44, 2005
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8WIA
 | | Crystal structure of E. coli ThrS catalytic domain mutant G463S | | 分子名称: | Threonine--tRNA ligase, ZINC ION | | 著者 | Qiao, H, Wang, Z, Wang, J, Fang, P. | | 登録日 | 2023-09-24 | | 公開日 | 2024-07-24 | | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | | 主引用文献 | Specific glycine-dependent enzyme motion determines the potency of conformation selective inhibitors of threonyl-tRNA synthetase.
Commun Biol, 7, 2024
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8WIG
 | | Crystal structure of E. coli ThrS catalytic domain mutant G463S/Q484A | | 分子名称: | Threonine--tRNA ligase, ZINC ION | | 著者 | Qiao, H, Wang, Z, Wang, J, Fang, P. | | 登録日 | 2023-09-24 | | 公開日 | 2024-07-24 | | 実験手法 | X-RAY DIFFRACTION (3.22 Å) | | 主引用文献 | Specific glycine-dependent enzyme motion determines the potency of conformation selective inhibitors of threonyl-tRNA synthetase.
Commun Biol, 7, 2024
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7OA6
 | | Pseudo-atomic model for Hsp26 residues 63 to 214. Please be advised that the target map is not of sufficient resolution to unambiguously position backbone or side chain atoms. This model represents a likely fit. | | 分子名称: | Heat shock protein 26 | | 著者 | Muehlhofer, M, Peters, C, Kriehuber, T, Kreuzeder, M, Kazman, P, Rodina, N, Reif, B, Haslbeck, M, Weinkauf, S, Buchner, J. | | 登録日 | 2021-04-19 | | 公開日 | 2021-11-24 | | 最終更新日 | 2024-07-10 | | 実験手法 | ELECTRON MICROSCOPY (7.8 Å) | | 主引用文献 | Phosphorylation activates the yeast small heat shock protein Hsp26 by weakening domain contacts in the oligomer ensemble.
Nat Commun, 12, 2021
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6NNW
 | | Tsn15 in complex with substrate intermediate | | 分子名称: | (3E)-3-{(1S,4S,4aS,5R,8aS)-1-[(2E,4R,7S,8E,10S)-1,7-dihydroxy-10-{(2R,3S,5R)-5-[(1S)-1-methoxyethyl]-3-methyloxolan-2-yl}-4-methylundeca-2,8-dien-2-yl]-4,5-dimethyloctahydro-3H-2-benzopyran-3-ylidene}oxolane-2,4-dione, PHOSPHATE ION, PROPANOIC ACID, ... | | 著者 | Paiva, F.C.R, Little, R, Leadlay, P, Dias, M.V.B. | | 登録日 | 2019-01-15 | | 公開日 | 2019-10-23 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Unexpected enzyme-catalysed [4+2] cycloaddition and rearrangement in polyether antibiotic biosynthesis
Nat Catal, 2019
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4MEN
 | | Crystal Structure of the first bromodomain of human BRD4 in complex with a 5-methyl-triazolopyrimidine ligand | | 分子名称: | 1,2-ETHANEDIOL, Bromodomain-containing protein 4, N,5-dimethyl-N-(4-methylbenzyl)[1,2,4]triazolo[1,5-a]pyrimidin-7-amine | | 著者 | Filippakopoulos, P, Picaud, S, Felletar, I, Martin, S, Fedorov, O, Vidler, L.R, Brown, N, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Hoelder, S, Knapp, S, Structural Genomics Consortium (SGC) | | 登録日 | 2013-08-27 | | 公開日 | 2013-09-25 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.81 Å) | | 主引用文献 | Discovery of Novel Small-Molecule Inhibitors of BRD4 Using Structure-Based Virtual Screening.
J.Med.Chem., 56, 2013
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7TB4
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8WIH
 | | Crystal structure of E. coli ThrS catalytic domain mutant G463A in complex with ATP | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Threonine--tRNA ligase, ZINC ION | | 著者 | Qiao, H, Wang, Z, Wang, J, Fang, P. | | 登録日 | 2023-09-24 | | 公開日 | 2024-07-24 | | 実験手法 | X-RAY DIFFRACTION (2.44 Å) | | 主引用文献 | Specific glycine-dependent enzyme motion determines the potency of conformation selective inhibitors of threonyl-tRNA synthetase.
Commun Biol, 7, 2024
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7O6P
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4MAH
 | | Structure of Aspergillus oryzae AA11 Lytic Polysaccharide Monooxygenase with Zn | | 分子名称: | 1,2-ETHANEDIOL, AA11 Lytic Polysaccharide Monooxygenase, CHLORIDE ION, ... | | 著者 | Hemsworth, G.R, Henrissat, B, Walton, P.H, Davies, G.J. | | 登録日 | 2013-08-16 | | 公開日 | 2013-12-18 | | 最終更新日 | 2017-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | Discovery and characterization of a new family of lytic polysaccharide monooxygenases.
Nat.Chem.Biol., 10, 2014
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3NAN
 | | SR Ca(2+)-ATPase in the HnE2 state complexed with a Thapsigargin derivative Boc-(phi)Tg | | 分子名称: | (3S,3aR,4S,6S,6aR,7S,8S,9R,9aS,9bS)-6-(acetyloxy)-4-{[4-(3-{6-[(tert-butoxycarbonyl)amino]hexyl}-4-hydroxyphenyl)butanoyl]oxy}-3,3a-dihydroxy-3,6,9-trimethyl-8-{[(2Z)-2-methylbut-2-enoyl]oxy}-2-oxododecahydroazuleno[4,5-b]furan-7-yl octanoate, MAGNESIUM ION, PHOSPHATIDYLETHANOLAMINE, ... | | 著者 | Winther, A.M.L, Sonntag, Y, Olesen, C, Moller, J.V, Nissen, P. | | 登録日 | 2010-06-02 | | 公開日 | 2010-06-30 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Critical roles of hydrophobicity and orientation of side chains for inactivation of sarcoplasmic reticulum Ca2+-ATPase with thapsigargin and thapsigargin analogs
J.Biol.Chem., 285, 2010
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8WII
 | | Crystal structure of E. coli ThrS catalytic domain mutant G463A in complex with Obafluorin | | 分子名称: | Threonine--tRNA ligase, ZINC ION, ~{N}-[(2~{R},3~{S})-2-[(4-nitrophenyl)methyl]-4-oxidanylidene-oxetan-3-yl]-2,3-bis(oxidanyl)benzamide | | 著者 | Qiao, H, Wang, Z, Wang, J, Fang, P. | | 登録日 | 2023-09-24 | | 公開日 | 2024-07-24 | | 実験手法 | X-RAY DIFFRACTION (2.98 Å) | | 主引用文献 | Specific glycine-dependent enzyme motion determines the potency of conformation selective inhibitors of threonyl-tRNA synthetase.
Commun Biol, 7, 2024
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1K83
 | | Crystal Structure of Yeast RNA Polymerase II Complexed with the Inhibitor Alpha Amanitin | | 分子名称: | ALPHA AMANITIN, DNA-DIRECTED RNA POLYMERASE II 13.6KD POLYPEPTIDE, DNA-DIRECTED RNA POLYMERASE II 14.2KD POLYPEPTIDE, ... | | 著者 | Bushnell, D.A, Cramer, P, Kornberg, R.D. | | 登録日 | 2001-10-22 | | 公開日 | 2002-02-13 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Structural Basis of Transcription: Alpha-Amanitin-RNA Polymerase II Cocrystal at 2.8 A Resolution.
Proc.Natl.Acad.Sci.USA, 99, 2002
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1YHG
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