8PY6
 
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6W03
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8PY7
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8PY8
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8PY9
 | | Isopenicillin N synthase in complex with Fe, O2, ACdV or thioaldehyde after 3s O2 exposure | | 分子名称: | (2S)-2-azanyl-6-[[(2R)-1-[[(2R)-3-methyl-1-oxidanyl-1-oxidanylidene-butan-2-yl]amino]-1-oxidanylidene-3-sulfanylidene-propan-2-yl]amino]-6-oxidanylidene-hexanoic acid, FE (III) ION, Isopenicillin N synthase, ... | | 著者 | Rabe, P, Schofield, C.J. | | 登録日 | 2023-07-25 | | 公開日 | 2024-08-07 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Isopenicillin N synthase in complex with Fe, O2, ACdV or thioaldehyde after 3s O2 exposure
To Be Published
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7SPA
 | | Chlorella virus Hyaluronan Synthase in the GlcNAc-primed, channel-open state | | 分子名称: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, ... | | 著者 | Maloney, F.P, Kuklewicz, J, Zimmer, J. | | 登録日 | 2021-11-02 | | 公開日 | 2022-04-06 | | 最終更新日 | 2022-04-20 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Structure, substrate recognition and initiation of hyaluronan synthase.
Nature, 604, 2022
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8PYA
 | | Isopenicillin N synthase in complex with Fe, O2, ACdV or thioaldehyde after 4s O2 exposure | | 分子名称: | (2S)-2-azanyl-6-[[(2R)-1-[[(2R)-3-methyl-1-oxidanyl-1-oxidanylidene-butan-2-yl]amino]-1-oxidanylidene-3-sulfanylidene-propan-2-yl]amino]-6-oxidanylidene-hexanoic acid, FE (III) ION, Isopenicillin N synthase, ... | | 著者 | Rabe, P, Schofield, C.J. | | 登録日 | 2023-07-25 | | 公開日 | 2024-08-07 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Isopenicillin N synthase in complex with Fe, O2, ACdV or thioaldehyde after 4s O2 exposure
To Be Published
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7OD1
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5FRM
 | | Crystal structure of the Prototype Foamy Virus (PFV) intasome in complex with magnesium and the INSTI XZ384 (compound 4a) | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 4-azanylidene-N-[[2,4-bis(fluoranyl)phenyl]methyl]-1-oxidanyl-2-oxidanylidene-1,8-naphthyridine-3-carboxamide, 5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP *TP*CP*GP*CP*A)-3', ... | | 著者 | Maskell, D.P, Pye, V.E, Cherepanov, P. | | 登録日 | 2015-12-18 | | 公開日 | 2016-02-17 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.58 Å) | | 主引用文献 | HIV-1 Integrase Strand Transfer Inhibitors with Reduced Susceptibility to Drug Resistant Mutant Integrases.
Acs Chem.Biol., 11, 2016
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7SP6
 | | Chlorella virus hyaluronan synthase | | 分子名称: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, CHOLESTEROL HEMISUCCINATE, Hyaluronan synthase, ... | | 著者 | Maloney, F.P, Kuklewicz, J, Zimmer, J. | | 登録日 | 2021-11-02 | | 公開日 | 2022-04-06 | | 最終更新日 | 2022-04-20 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Structure, substrate recognition and initiation of hyaluronan synthase.
Nature, 604, 2022
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7BI7
 | | An Unexpected P-Cluster like Intermediate En Route to the Nitrogenase FeMo-co | | 分子名称: | FE(8)-S(7) CLUSTER, FeMo cofactor biosynthesis protein NifB, HYDROSULFURIC ACID, ... | | 著者 | Jenner, L.P, Cherrier, M.V, Amara, P, Rubio, L.M, Nicolet, Y. | | 登録日 | 2021-01-12 | | 公開日 | 2021-03-10 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | An unexpected P-cluster like intermediate en route to the nitrogenase FeMo-co.
Chem Sci, 12, 2021
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8TNU
 | | Cryo-EM structure of TRNM-b*01 Fab in complex with HIV-1 Env trimer BG505.DS SOSIP | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BG505 DS-SOSIP Surface protein gp120, ... | | 著者 | Roark, R.S, Morano, N.C, Shapiro, L.S, Kwong, P.D. | | 登録日 | 2023-08-02 | | 公開日 | 2024-08-07 | | 実験手法 | ELECTRON MICROSCOPY (3.36 Å) | | 主引用文献 | Broad and potent HIV-1 neutralization in fusion peptide-primed SHIV-boosted macaques
To Be Published
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8TO7
 | | Cryo-EM structure of HERH-b*01 Fab in complex with HIV-1 Env trimer BG505.DS SOSIP | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, HERH-b*01 heavy chain, ... | | 著者 | Roark, R.S, Hoyt, F, Hansen, B, Fischer, E, Shapiro, L.S, Kwong, P.D. | | 登録日 | 2023-08-03 | | 公開日 | 2024-08-07 | | 実験手法 | ELECTRON MICROSCOPY (3.39 Å) | | 主引用文献 | Broad and potent HIV-1 neutralization in fusion peptide-primed SHIV-boosted macaques
To Be Published
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3C5D
 | | Crystal structure of HIV-1 subtype F DIS extended duplex RNA bound to lividomycin | | 分子名称: | 'HIV-1 subtype F genomic RNA, (2R,3S,4S,5S,6R)-2-((2S,3S,4R,5R,6R)-5-AMINO-2-(AMINOMETHYL)-6-((2R,3S,4R,5S)-5-((1R,2R,3S,5R,6S)-3,5-DIAMINO-2-((2S,3R ,5S,6R)-3-AMINO-5-HYDROXY-6-(HYDROXYMETHYL)-TETRAHYDRO-2H-PYRAN-2-YLOXY)-6-HYDROXYCYCLOHEXYLOXY)-4-HYDROXY-2-(HYDROXYMET HYL)-TETRAHYDROFURAN-3-YLOXY)-4-HYDROXY-TETRAHYDRO-2H-PYRAN-3-YLOXY)-6-(HYDROXYMETHYL)-TETRAHYDRO-2H-PYRAN-3,4,5-TRIOL, POTASSIUM ION | | 著者 | Freisz, S, Lang, K, Micura, R, Dumas, P, Ennifar, E. | | 登録日 | 2008-01-31 | | 公開日 | 2008-05-06 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Binding of aminoglycoside antibiotics to the duplex form of the HIV-1 genomic RNA dimerization initiation site.
Angew.Chem.Int.Ed.Engl., 47, 2008
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8FU2
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8FU5
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7SP8
 | | Chlorella virus Hyaluronan Synthase bound to UDP-GlcNAc | | 分子名称: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, CHOLESTEROL HEMISUCCINATE, Hyaluronan synthase, ... | | 著者 | Maloney, F.P, Kuklewicz, J, Zimmer, J. | | 登録日 | 2021-11-02 | | 公開日 | 2022-04-06 | | 最終更新日 | 2022-04-20 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Structure, substrate recognition and initiation of hyaluronan synthase.
Nature, 604, 2022
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7SP7
 | | Chlorella virus hyaluronan synthase inhibited by UDP | | 分子名称: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, CHOLESTEROL HEMISUCCINATE, Hyaluronan synthase, ... | | 著者 | Maloney, F.P, Kuklewicz, J, Zimmer, J. | | 登録日 | 2021-11-02 | | 公開日 | 2022-04-06 | | 最終更新日 | 2022-04-20 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Structure, substrate recognition and initiation of hyaluronan synthase.
Nature, 604, 2022
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6VR7
 | | Structure of a pseudomurein peptide ligase type C from Methanothermus fervidus | | 分子名称: | ACETOACETIC ACID, GLYCEROL, Mur ligase middle domain protein, ... | | 著者 | Carbone, V, Schofield, L.R, Sutherland-Smith, A.J, Ronimus, R.S, Subedi, B.P. | | 登録日 | 2020-02-06 | | 公開日 | 2021-02-10 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Archaeal pseudomurein and bacterial murein cell wall biosynthesis share a common evolutionary ancestry
FEMS Microbes, 2, 2021
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2KCV
 | | Solution nmr structure of tetratricopeptide repeat domain protein sru_0103 from salinibacter ruber, northeast structural genomics consortium (nesg) target srr115c | | 分子名称: | Tetratricopeptide repeat domain protein | | 著者 | Liu, G, Rossi, P, Wang, D, Nwosu, C, Owens, L, Xiao, R, Liu, J, Baran, M.C, Swapna, G, Acton, T.B, Rost, B, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | | 登録日 | 2008-12-29 | | 公開日 | 2009-01-20 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution nmr structure of tetratricopeptide repeat domain protein sru_0103 from salinibacter ruber, northeast structural genomics consortium (nesg) target srr115c
To be Published
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7O0O
 | | Crystal structure of the B3 metallo-beta-lactamase L1 with hydrolysed ertapenem | | 分子名称: | (2~{S},3~{R},4~{S})-2-[(2~{S},3~{R})-1,3-bis(oxidanyl)-1-oxidanylidene-butan-2-yl]-4-[(3~{S},5~{S})-5-[(3-carboxyphenyl)carbamoyl]pyrrolidin-3-yl]sulfanyl-3-methyl-3,4-dihydro-2~{H}-pyrrole-5-carboxylic acid, Metallo-beta-lactamase L1, SULFATE ION, ... | | 著者 | Hinchliffe, P, Spencer, J. | | 登録日 | 2021-03-26 | | 公開日 | 2021-10-13 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | | 主引用文献 | Crystallography and QM/MM Simulations Identify Preferential Binding of Hydrolyzed Carbapenem and Penem Antibiotics to the L1 Metallo-beta-Lactamase in the Imine Form.
J.Chem.Inf.Model., 61, 2021
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7NRO
 | | Crystal structure of AlkB in complex with manganese and N-(4-((6-((carboxymethyl)carbamoyl)-5-hydroxypyridin-2-yl)amino)phenyl)-N-oxohydroxylammonium | | 分子名称: | 2-[[6-[(4-nitrophenyl)amino]-3-oxidanyl-pyridin-2-yl]carbonylamino]ethanoic acid, Alpha-ketoglutarate-dependent dioxygenase AlkB, MANGANESE (II) ION | | 著者 | Shishodia, S, Maheswaran, P, Leissing, T, Aik, W.S, McDonough, M.A, Schofield, C.J. | | 登録日 | 2021-03-04 | | 公開日 | 2021-10-13 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | | 主引用文献 | Structure-Based Design of Selective Fat Mass and Obesity Associated Protein (FTO) Inhibitors.
J.Med.Chem., 64, 2021
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3C7R
 | | Crystal Structure of HIV-1 subtype F DIS extended duplex RNA bound to neomycin | | 分子名称: | HIV-1 subtype F genomic RNA, NEOMYCIN, POTASSIUM ION | | 著者 | Freisz, S, Lang, K, Micura, R, Dumas, P, Ennifar, E. | | 登録日 | 2008-02-08 | | 公開日 | 2008-05-06 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Binding of aminoglycoside antibiotics to the duplex form of the HIV-1 genomic RNA dimerization initiation site.
Angew.Chem.Int.Ed.Engl., 47, 2008
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5MQL
 | | Crystal structure of dCK mutant C3S in complex with masitinib and UDP | | 分子名称: | 2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE, Deoxycytidine kinase, MAGNESIUM ION, ... | | 著者 | Rebuffet, E, Hammam, K, Saez-Ayala, M, Gros, L, Lopez, S, Hajem, B, Humbert, M, Baudelet, E, Audebert, S, Betzi, S, Lugari, A, Combes, S, Pez, D, Letard, S, Mansfield, C, Moussy, A, de Sepulveda, P, Morelli, X, Dubreuil, P. | | 登録日 | 2016-12-20 | | 公開日 | 2017-11-22 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (3.25 Å) | | 主引用文献 | Dual protein kinase and nucleoside kinase modulators for rationally designed polypharmacology.
Nat Commun, 8, 2017
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6W10
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