6W10

Structure of mouse TREX1 with E198K disease-associated mutation

Summary for 6W10

Entry DOI	10.2210/pdb6w10/pdb
Descriptor	Three-prime repair exonuclease 1 (2 entities in total)
Functional Keywords	nuclease, dnase, innate immunity, autoimmunity, hydrolase
Biological source	Mus musculus (Mouse)
Total number of polymer chains	2
Total formula weight	52822.21
Authors	Zhou, W.,Mohr, L.,Maciejowski, J.,Kranzusch, P.J. (deposition date: 2020-03-03, release date: 2021-02-17, Last modification date: 2023-10-18)
Primary citation	Zhou, W.,Mohr, L.,Maciejowski, J.,Kranzusch, P.J. cGAS phase separation inhibits TREX1-mediated DNA degradation and enhances cytosolic DNA sensing. Mol.Cell, 81:739-755.e7, 2021 Cited by PubMed: 33606975 DOI: 10.1016/j.molcel.2021.01.024 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.80003386368 Å)

Structure validation