3C5D

Crystal structure of HIV-1 subtype F DIS extended duplex RNA bound to lividomycin

Summary for 3C5D

Related2QEK 3C44 3C3Z
Descriptor'HIV-1 subtype F genomic RNA, POTASSIUM ION, (2R,3S,4S,5S,6R)-2-((2S,3S,4R,5R,6R)-5-AMINO-2-(AMINOMETHYL)-6-((2R,3S,4R,5S)-5-((1R,2R,3S,5R,6S)-3,5-DIAMINO-2-((2S,3R,5S,6R)-3-AMINO-5-HYDROXY-6-(HYDROXYMETHYL)-TETRAHYDRO-2H-PYRAN-2-YLOXY)-6-HYDROXYCYCLOHEXYLOXY)-4-HYDROXY-2-(HYDROXYMETHYL)-TETRAHYDROFURAN-3-YLOXY)-4-HYDROXY-TETRAHYDRO-2H-PYRAN-3-YLOXY)-6-(HYDROXYMETHYL)-TETRAHYDRO-2H-PYRAN-3,4,5-TRIOL, ... (4 entities in total)
Functional Keywordshiv-1, rna, aminoglycoside, lividomycin, extended duplex
Total number of polymer chains2
Total molecular weight16528.65
Authors
Freisz, S.,Lang, K.,Micura, R.,Dumas, P.,Ennifar, E. (deposition date: 2008-01-31, release date: 2008-05-06, Last modification date: 2011-07-13)
Primary citation
Freisz, S.,Lang, K.,Micura, R.,Dumas, P.,Ennifar, E.
Binding of aminoglycoside antibiotics to the duplex form of the HIV-1 genomic RNA dimerization initiation site.
Angew.Chem.Int.Ed.Engl., 47:4110-4113, 2008
PubMed: 18435520 (PDB entries with the same primary citation)
DOI: 10.1002/anie.200800726
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.8 Å)
?

Structure validation

RfreeClashscoreRSRZ outliers0.259150MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 3c5d
no rotation
Molmil generated image of 3c5d
rotated about x axis by 90°
Molmil generated image of 3c5d
rotated about y axis by 90°
PDBj@FacebookPDBj@TwitterwwPDBwwPDB Foundation

Copyright © 2013-2019 Protein Data Bank Japan