7NRO
Crystal structure of AlkB in complex with manganese and N-(4-((6-((carboxymethyl)carbamoyl)-5-hydroxypyridin-2-yl)amino)phenyl)-N-oxohydroxylammonium
Summary for 7NRO
Entry DOI | 10.2210/pdb7nro/pdb |
Related | 3T3Y |
Descriptor | Alpha-ketoglutarate-dependent dioxygenase AlkB, 2-[[6-[(4-nitrophenyl)amino]-3-oxidanyl-pyridin-2-yl]carbonylamino]ethanoic acid, MANGANESE (II) ION, ... (4 entities in total) |
Functional Keywords | alpha ketoglutarate and iron dependent oxygenase, dna demethylase, inhibitor complex, oxidoreductase |
Biological source | Escherichia coli K-12 |
Total number of polymer chains | 1 |
Total formula weight | 24491.72 |
Authors | Shishodia, S.,Maheswaran, P.,Leissing, T.,Aik, W.S.,McDonough, M.A.,Schofield, C.J. (deposition date: 2021-03-04, release date: 2021-10-13, Last modification date: 2024-01-31) |
Primary citation | Shishodia, S.,Demetriades, M.,Zhang, D.,Tam, N.Y.,Maheswaran, P.,Clunie-O'Connor, C.,Tumber, A.,Leung, I.K.H.,Ng, Y.M.,Leissing, T.M.,El-Sagheer, A.H.,Salah, E.,Brown, T.,Aik, W.S.,McDonough, M.A.,Schofield, C.J. Structure-Based Design of Selective Fat Mass and Obesity Associated Protein (FTO) Inhibitors. J.Med.Chem., 64:16609-16625, 2021 Cited by PubMed: 34762429DOI: 10.1021/acs.jmedchem.1c01204 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.25 Å) |
Structure validation
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