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PDB: 319 件
2ZNO
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BU of 2zno by Molmil
Human PPAR gamma ligand binding domain in complex with a synthetic agonist TIPP703
分子名称: (2S)-2-(4-propoxy-3-{[({4-[(3S,5S,7S)-tricyclo[3.3.1.1~3,7~]dec-1-yl]phenyl}carbonyl)amino]methyl}benzyl)butanoic acid, Peroxisome proliferator-activated receptor gamma
著者Oyama, T, Waku, T, Kasuga, J, Miyachi, H, Morikawa, K.
登録日2008-04-30
公開日2009-05-05
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Adaptability and selectivity of human peroxisome proliferator-activated receptor (PPAR) pan agonists revealed from crystal structures
Acta Crystallogr.,Sect.D, 65, 2009
2ZNN
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BU of 2znn by Molmil
Human PPAR alpha ligand binding domain in complex with a synthetic agonist TIPP703
分子名称: (2S)-2-(4-propoxy-3-{[({4-[(3S,5S,7S)-tricyclo[3.3.1.1~3,7~]dec-1-yl]phenyl}carbonyl)amino]methyl}benzyl)butanoic acid, Peroxisome proliferator-activated receptor alpha
著者Oyama, T, Toyota, K, Kasuga, J, Miyachi, H, Morikawa, K.
登録日2008-04-30
公開日2009-05-05
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.01 Å)
主引用文献Adaptability and selectivity of human peroxisome proliferator-activated receptor (PPAR) pan agonists revealed from crystal structures
Acta Crystallogr.,Sect.D, 65, 2009
3W0K
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BU of 3w0k by Molmil
Crystal Structure of a glycoside hydrolase
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Bifunctional endomannanase/endoglucanase
著者Oyama, T, Nakamura, H, Morikawa, K, Cann, I.K.O.
登録日2012-10-31
公開日2013-02-20
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Crystal structure of a glycoside hydrolase
To be Published
3WMH
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BU of 3wmh by Molmil
Human PPAR gamma ligand binding domain in complex with a gammma selective synthetic partial agonist MEKT75
分子名称: N-(phenylsulfonyl)-4-propoxy-3-({[4-(pyrimidin-2-yl)benzoyl]amino}methyl)benzamide, Peroxisome proliferator-activated receptor gamma
著者Oyama, T, Ohashi, M, Miyachi, H, Kusunoki, M.
登録日2013-11-19
公開日2014-11-19
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Human PPRR gamma ligand binding domain in complex with a gammma selective synthetic partial agonist MEKT75
TO BE PUBLISHED
3ANW
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BU of 3anw by Molmil
A protein complex essential initiation of DNA replication
分子名称: Putative uncharacterized protein
著者Oyama, T, Shirai, T, Nagasawa, N, Ishino, Y, Morikawa, K.
登録日2010-09-10
公開日2011-07-27
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Architectures of archaeal GINS complexes, essential DNA replication initiation factors
Bmc Biol., 9, 2011
2ZJ5
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BU of 2zj5 by Molmil
Archaeal DNA helicase Hjm complexed with ADP in form 1
分子名称: ADENOSINE-5'-DIPHOSPHATE, Putative ski2-type helicase, SULFATE ION
著者Oyama, T, Oka, H, Fujikane, R, Ishino, Y, Morikawa, K.
登録日2008-02-29
公開日2009-02-10
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Atomic structures and functional implications of the archaeal RecQ-like helicase Hjm
Bmc Struct.Biol., 9, 2009
2ZJA
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BU of 2zja by Molmil
Archaeal DNA helicase Hjm complexed with AMPPCP in form 2
分子名称: PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, Putative ski2-type helicase
著者Oyama, T, Oka, H, Fujikane, R, Ishino, Y, Morikawa, K.
登録日2008-02-29
公開日2009-02-10
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Atomic structures and functional implications of the archaeal RecQ-like helicase Hjm
Bmc Struct.Biol., 9, 2009
2ZJ2
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BU of 2zj2 by Molmil
Archaeal DNA helicase Hjm apo state in form 1
分子名称: Putative ski2-type helicase, SULFATE ION
著者Oyama, T, Oka, H, Fujikane, R, Ishino, Y, Morikawa, K.
登録日2008-02-29
公開日2009-02-10
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Atomic structures and functional implications of the archaeal RecQ-like helicase Hjm
Bmc Struct.Biol., 9, 2009
2ZJ8
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BU of 2zj8 by Molmil
Archaeal DNA helicase Hjm apo state in form 2
分子名称: Putative ski2-type helicase
著者Oyama, T, Oka, H, Fujikane, R, Ishino, Y, Morikawa, K.
登録日2008-02-29
公開日2009-02-10
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Atomic structures and functional implications of the archaeal RecQ-like helicase Hjm
Bmc Struct.Biol., 9, 2009
3AN3
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BU of 3an3 by Molmil
Human PPAR gamma ligand binding domain in complex with a gamma selective agonist MO3S
分子名称: (2S)-2-benzyl-3-(4-propoxy-3-{[({4-[(3S,5S,7S)-tricyclo[3.3.1.1~3,7~]dec-1-yl]phenyl}carbonyl)amino]methyl}phenyl)propanoic acid, Peroxisome proliferator-activated receptor gamma
著者Oyama, T, Ohashi, M, Waku, T, Miyachi, H, Morikawa, K.
登録日2010-08-30
公開日2011-07-27
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Design, Synthesis, and Structural Analysis of Phenylpropanoic Acid-Type PPAR gamma-Selective Agonists: Discovery of Reversed Stereochemistry-Activity Relationship
J.Med.Chem., 54, 2011
3AN4
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BU of 3an4 by Molmil
Human PPAR gamma ligand binding domain in complex with a gamma selective agonist MO4R
分子名称: (2R)-2-benzyl-3-(4-propoxy-3-{[({4-[(3S,5S,7S)-tricyclo[3.3.1.1~3,7~]dec-1-yl]phenyl}carbonyl)amino]methyl}phenyl)propanoic acid, Peroxisome proliferator-activated receptor gamma
著者Oyama, T, Ohashi, M, Waku, T, Miyachi, H, Morikawa, K.
登録日2010-08-30
公開日2011-07-27
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Design, Synthesis, and Structural Analysis of Phenylpropanoic Acid-Type PPAR gamma-Selective Agonists: Discovery of Reversed Stereochemistry-Activity Relationship
J.Med.Chem., 54, 2011
6KGB
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BU of 6kgb by Molmil
Crystal structure of E61K mutated transthyretin
分子名称: CALCIUM ION, Transthyretin
著者Yokoyama, T, Mizuguchi, M.
登録日2019-07-11
公開日2020-07-22
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献A low amyloidogenic E61K transthyretin mutation may cause familial amyloid polyneuropathy.
J.Neurochem., 156, 2021
3U2J
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BU of 3u2j by Molmil
Neutron crystal structure of human Transthyretin
分子名称: Transthyretin
著者Yokoyama, T, Mizuguchi, M, Nabeshima, Y, Kusaka, K, Yamada, T, Hosoya, T, Ohhara, T, Kurihara, K, Tomoyori, K, Tanaka, I, Niimura, N.
登録日2011-10-03
公開日2012-02-22
最終更新日2023-11-01
実験手法NEUTRON DIFFRACTION (2 Å)
主引用文献Hydrogen-bond network and pH sensitivity in transthyretin: Neutron crystal structure of human transthyretin
J.Struct.Biol., 177, 2012
3U2I
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X-ray crystal structure of human Transthyretin at room temperature
分子名称: Transthyretin
著者Yokoyama, T, Mizuguchi, M, Nabeshima, Y, Kusaka, K, Yamada, T, Hosoya, T, Ohhara, T, Kurihara, K, Tomoyori, K, Tanaka, I, Niimura, N.
登録日2011-10-03
公開日2012-02-22
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Hydrogen-bond network and pH sensitivity in transthyretin: Neutron crystal structure of human transthyretin
J.Struct.Biol., 177, 2012
8WGT
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BU of 8wgt by Molmil
Crystal structure of V30M-TTR in complex with compound 7
分子名称: Transthyretin, [4,7-bis(chloranyl)-2-ethyl-1-benzofuran-3-yl]-[3,5-bis(iodanyl)-4-oxidanyl-phenyl]methanone
著者Yokoyama, T.
登録日2023-09-22
公開日2024-05-15
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (1.696 Å)
主引用文献Development of Benziodarone Analogues with Enhanced Potency for Selective Binding to Transthyretin in Human Plasma.
J.Med.Chem., 67, 2024
8WGS
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BU of 8wgs by Molmil
Crystal structure of V30M-TTR in complex with compound 4
分子名称: Transthyretin, [3,5-bis(iodanyl)-4-oxidanyl-phenyl]-(2-ethyl-4-iodanyl-1-benzofuran-3-yl)methanone
著者Yokoyama, T.
登録日2023-09-22
公開日2024-05-15
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (1.801 Å)
主引用文献Development of Benziodarone Analogues with Enhanced Potency for Selective Binding to Transthyretin in Human Plasma.
J.Med.Chem., 67, 2024
8WGU
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BU of 8wgu by Molmil
Crystal structure of V30M-TTR in complex with compound 20
分子名称: Transthyretin, [3,5-bis(iodanyl)-4-oxidanyl-phenyl]-[2-ethyl-4,7-bis(fluoranyl)-1-benzofuran-3-yl]methanone
著者Yokoyama, T.
登録日2023-09-22
公開日2024-05-15
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (1.508 Å)
主引用文献Development of Benziodarone Analogues with Enhanced Potency for Selective Binding to Transthyretin in Human Plasma.
J.Med.Chem., 67, 2024
3J0E
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BU of 3j0e by Molmil
Models for the T. thermophilus ribosome recycling factor and the E. coli elongation factor G bound to the E. coli post-termination complex
分子名称: 30S ribosomal protein S12, Elongation factor G, Ribosome-recycling factor, ...
著者Yokoyama, T, Shaikh, T.R, Iwakura, N, Kaji, H, Kaji, A, Agrawal, R.K.
登録日2011-06-29
公開日2012-04-25
最終更新日2024-02-21
実験手法ELECTRON MICROSCOPY (9.9 Å)
主引用文献Structural insights into initial and intermediate steps of the ribosome-recycling process.
Embo J., 31, 2012
6IP6
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BU of 6ip6 by Molmil
Cryo-EM structure of the CMV-stalled human 80S ribosome with HCV IRES (Structure iii)
分子名称: 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ...
著者Yokoyama, T, Shigematsu, H, Shirouzu, M, Imataka, H, Ito, T.
登録日2018-11-02
公開日2019-05-29
最終更新日2019-11-06
実験手法ELECTRON MICROSCOPY (4.5 Å)
主引用文献HCV IRES Captures an Actively Translating 80S Ribosome.
Mol.Cell, 74, 2019
6IP8
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BU of 6ip8 by Molmil
Cryo-EM structure of the HCV IRES dependently initiated CMV-stalled 80S ribosome (Structure iv)
分子名称: 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ...
著者Yokoyama, T, Shigematsu, H, Shirouzu, M, Imataka, H, Ito, T.
登録日2018-11-02
公開日2019-05-29
最終更新日2019-11-06
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献HCV IRES Captures an Actively Translating 80S Ribosome.
Mol.Cell, 74, 2019
6IP5
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BU of 6ip5 by Molmil
Cryo-EM structure of the CMV-stalled human 80S ribosome (Structure ii)
分子名称: 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ...
著者Yokoyama, T, Shigematsu, H, Shirouzu, M, Imataka, H, Ito, T.
登録日2018-11-02
公開日2019-05-29
最終更新日2019-11-06
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献HCV IRES Captures an Actively Translating 80S Ribosome.
Mol.Cell, 74, 2019
5H0Z
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BU of 5h0z by Molmil
Crystal structure of P113A mutated human transthyretin
分子名称: CHLORIDE ION, SULFATE ION, Transthyretin
著者Yokoyama, T, Hanawa, Y, Obita, T, Mizuguchi, M.
登録日2016-10-07
公開日2017-06-14
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (1.735 Å)
主引用文献Stability and crystal structures of His88 mutant human transthyretins
FEBS Lett., 591, 2017
5H0V
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BU of 5h0v by Molmil
Crystal structure of H88A mutated human transthyretin
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, MAGNESIUM ION, Transthyretin
著者Yokoyama, T, Hanawa, Y, Obita, T, Mizuguchi, M.
登録日2016-10-07
公開日2017-06-14
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (1.58 Å)
主引用文献Stability and crystal structures of His88 mutant human transthyretins
FEBS Lett., 591, 2017
5H0X
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BU of 5h0x by Molmil
Crystal structure of H88S mutated human transthyretin
分子名称: Transthyretin
著者Yokoyama, T, Hanawa, Y, Obita, T, Mizuguchi, M.
登録日2016-10-07
公開日2017-06-14
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (1.573 Å)
主引用文献Stability and crystal structures of His88 mutant human transthyretins
FEBS Lett., 591, 2017
5H0W
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Crystal structure of H88F mutated human transthyretin
分子名称: SULFATE ION, Transthyretin
著者Yokoyama, T, Hanawa, Y, Obita, T, Mizuguchi, M.
登録日2016-10-07
公開日2017-06-14
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (1.904 Å)
主引用文献Stability and crystal structures of His88 mutant human transthyretins
FEBS Lett., 591, 2017

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