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PDB: 471 results

7OQA
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BU of 7oqa by Molmil
Ternary complex of 14-3-3 sigma, Pin1pS72 phosphopeptide, and WQ162
Descriptor: 14-3-3 protein sigma, CHLORIDE ION, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, ...
Authors:Centorrino, F, Ottmann, C.
Deposit date:2021-06-02
Release date:2022-08-10
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A crystallography-based study of fragment extensions into the 14-3-3 binding groove
To Be Published
7OQ9
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BU of 7oq9 by Molmil
Ternary complex of 14-3-3 sigma, Pin1pS72 phosphopeptide, and WQ136
Descriptor: 14-3-3 protein sigma, CHLORIDE ION, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, ...
Authors:Centorrino, F, Ottmann, C.
Deposit date:2021-06-02
Release date:2022-08-10
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A crystallography-based study of fragment extensions into the 14-3-3 binding groove
To Be Published
4N7G
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BU of 4n7g by Molmil
Crystal structure of 14-3-3zeta in complex with a peptide derived from ExoS
Descriptor: 14-3-3 protein zeta/delta, Exoenzyme S, HEXAETHYLENE GLYCOL
Authors:Bier, D, Glas, A, Hahne, G, Grossmann, T, Ottmann, C.
Deposit date:2013-10-15
Release date:2014-02-19
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Constrained peptides with target-adapted cross-links as inhibitors of a pathogenic protein-protein interaction.
Angew.Chem.Int.Ed.Engl., 53, 2014
4QLI
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BU of 4qli by Molmil
A novel phospho-switch in the linker region of the snail zinc finger protein which regulates 14-3-3 association, DNA binding and epithelial-mesenchymal differentiation
Descriptor: 14-3-3 protein sigma, GLYCEROL, MAGNESIUM ION, ...
Authors:Bier, D, Ottmann, C.
Deposit date:2014-06-12
Release date:2015-06-17
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:A novel phospho-switch in the linker region of the snail zinc finger protein which regulates 14-3-3 association, DNA binding and epithelial-mesenchymal differentiation
To be Published
4J24
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BU of 4j24 by Molmil
Estrogen Receptor in complex with proline-flanked LXXLL peptides
Descriptor: 19-mer peptide, ESTRADIOL, Estrogen receptor beta
Authors:Fuchs, S, Nguyen, H.D, Phan, T, Burton, M, Nieto, L, de Vries-van Leeuwen, I, Schmidt, A, Goodarzifard, M, Agten, S, Rose, R, Ottmann, C, Milroy, L.G, Brunsveld, L.
Deposit date:2013-02-04
Release date:2013-03-13
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Proline primed helix length as a modulator of the nuclear receptor-coactivator interaction
J.Am.Chem.Soc., 135, 2013
6ZCJ
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BU of 6zcj by Molmil
14-3-3sigma in complex with SLP76pS376 phosphopeptide crystal structure
Descriptor: 14-3-3 protein sigma, MAGNESIUM ION, SLP76pS376
Authors:Soini, L, Leysen, S, Davis, J, Ottmann, C.
Deposit date:2020-06-11
Release date:2020-12-02
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:The 14-3-3/SLP76 protein-protein interaction in T-cell receptor signalling: a structural and biophysical characterization.
Febs Lett., 595, 2021
5D3E
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BU of 5d3e by Molmil
Crystal structure of human 14-3-3 gamma in complex with CFTR R-domain peptide pS768-pS795
Descriptor: 14-3-3 protein gamma, Cystic fibrosis transmembrane conductance regulator
Authors:Stevers, L.M, Leysen, S.F.R, Ottmann, C.
Deposit date:2015-08-06
Release date:2016-03-16
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Characterization and small-molecule stabilization of the multisite tandem binding between 14-3-3 and the R domain of CFTR.
Proc.Natl.Acad.Sci.USA, 113, 2016
7B15
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BU of 7b15 by Molmil
14-3-3sigma in complex with SHN3pT869 phosphopeptide crystal structure
Descriptor: 14-3-3 protein sigma, MAGNESIUM ION, SHN3pT869
Authors:Soini, L, Leysen, S, Davis, J, Ottmann, C.
Deposit date:2020-11-23
Release date:2021-09-29
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:14-3-3 sigma in complex with phosphopeptides
To Be Published
7B13
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BU of 7b13 by Molmil
14-3-3sigma in complex with SHN3pS542 phosphopeptide crystal structure
Descriptor: 14-3-3 protein sigma, MAGNESIUM ION, SHN3pS542
Authors:Soini, L, Leysen, S, Davis, J, Ottmann, C.
Deposit date:2020-11-23
Release date:2021-09-29
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.37 Å)
Cite:14-3-3 sigma in complex with phosphopeptides
To Be Published
5D3F
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BU of 5d3f by Molmil
Crystal structure of human 14-3-3 zeta in complex with CFTR R-domain peptide pS753-pS768 and stabilizer fusicoccin-A
Descriptor: 14-3-3 protein zeta/delta, Cystic fibrosis transmembrane conductance regulator, FUSICOCCIN
Authors:Stevers, L.M, Leysen, S.F.R, Ottmann, C.
Deposit date:2015-08-06
Release date:2016-03-16
Last modified:2019-03-13
Method:X-RAY DIFFRACTION (2.74 Å)
Cite:Characterization and small-molecule stabilization of the multisite tandem binding between 14-3-3 and the R domain of CFTR.
Proc.Natl.Acad.Sci.USA, 113, 2016
6ZVC
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BU of 6zvc by Molmil
14-3-3 Sigma in complex with phosphorylated Gab2pT391 peptide - 48h incubation
Descriptor: 14-3-3 protein sigma, MAGNESIUM ION, phosphorylated Gab2pT391 peptide
Authors:Ballone, A, Lau, R.A, Zweipfenning, F.P.A, Ottmann, C.
Deposit date:2020-07-24
Release date:2021-08-04
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:A new soaking procedure for X-ray crystallography structural determination of protein-peptide complexes
To Be Published
6ZVB
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BU of 6zvb by Molmil
14-3-3 Sigma in complex with phosphorylated Gab2pT391 peptide - 24h incubation
Descriptor: 14-3-3 protein sigma, MAGNESIUM ION, phosphorylated Gab2pT391 peptide
Authors:Ballone, A, Lau, R.A, Zweipfenning, F.P.A, Ottmann, C.
Deposit date:2020-07-24
Release date:2021-08-04
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:A new soaking procedure for X-ray crystallography structural determination of protein-peptide complexes
To Be Published
6ZVE
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BU of 6zve by Molmil
14-3-3 Sigma in complex with phosphorylated Gab2pT391 peptide - 1h incubation
Descriptor: 14-3-3 protein sigma, MAGNESIUM ION, phosphorylated Gab2pT391 peptide
Authors:Ballone, A, Lau, R.A, Zweipfenning, F.P.A, Ottmann, C.
Deposit date:2020-07-24
Release date:2021-08-04
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:A new soaking procedure for X-ray crystallography structural determination of protein-peptide complexes
To Be Published
6ZVD
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BU of 6zvd by Molmil
14-3-3 Sigma in complex with phosphorylated Gab2pT391 peptide - 96h incubation
Descriptor: 14-3-3 protein sigma, MAGNESIUM ION, phosphorylated Gab2pT391 peptide
Authors:Ballone, A, Lau, R.A, Zweipfenning, F.P.A, Ottmann, C.
Deposit date:2020-07-24
Release date:2021-08-04
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A new soaking procedure for X-ray crystallography structural determination of protein-peptide complexes
To Be Published
5D2D
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BU of 5d2d by Molmil
Crystal structure of human 14-3-3 zeta in complex with CFTR R-domain peptide pS753-pS768
Descriptor: 14-3-3 protein zeta/delta, CHLORIDE ION, Cystic fibrosis transmembrane conductance regulator, ...
Authors:Stevers, L.M, Leysen, S.F.R, Ottmann, C.
Deposit date:2015-08-05
Release date:2016-03-16
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Characterization and small-molecule stabilization of the multisite tandem binding between 14-3-3 and the R domain of CFTR.
Proc.Natl.Acad.Sci.USA, 113, 2016
7AXN
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BU of 7axn by Molmil
14-3-3 sigma in complex with Pin1 binding site pS72 and covalently bound TCF521-026
Descriptor: 14-3-3 protein sigma, 3-chloranyl-4-imidazol-1-yl-benzaldehyde, CALCIUM ION, ...
Authors:Wolter, M, Dijck, L.v, Ottmann, C.
Deposit date:2020-11-10
Release date:2021-06-16
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions.
J.Am.Chem.Soc., 143, 2021
7AYF
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BU of 7ayf by Molmil
14-3-3 sigma with Pin1 binding site pS72 and covalently bound TCF521-110
Descriptor: 14-3-3 protein sigma, 6-(2-bromanylimidazol-1-yl)pyridine-3-carbaldehyde, CALCIUM ION, ...
Authors:Wolter, M, Dijck, L.v, Ottmann, C.
Deposit date:2020-11-12
Release date:2021-06-16
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.752 Å)
Cite:Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions.
J.Am.Chem.Soc., 143, 2021
7AZ2
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BU of 7az2 by Molmil
14-3-3 sigma with Pin1 binding site pS72 and covalently bound LvD1014
Descriptor: 1-[4-methyl-2-(trifluoromethyl)phenyl]-2-phenyl-imidazole, 14-3-3 protein sigma, CALCIUM ION, ...
Authors:Wolter, M, Dijck, L.v, Ottmann, C.
Deposit date:2020-11-14
Release date:2021-06-16
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.081 Å)
Cite:Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions.
J.Am.Chem.Soc., 143, 2021
7AOG
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BU of 7aog by Molmil
14-3-3 sigma in complex with Pin1 binding site pS72
Descriptor: 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ...
Authors:Wolter, M, Dijck, L.v, Cossar, P.J, Ottmann, C.
Deposit date:2020-10-14
Release date:2021-06-16
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions.
J.Am.Chem.Soc., 143, 2021
7AZ1
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BU of 7az1 by Molmil
14-3-3 sigma with Pin1 binding site pS72 and covalently bound LvD1013
Descriptor: 1-[4-methyl-3-(trifluoromethyl)phenyl]-2-phenyl-imidazole, 14-3-3 protein sigma, CALCIUM ION, ...
Authors:Wolter, M, Dijck, L.v, Ottmann, C.
Deposit date:2020-11-14
Release date:2021-06-16
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions.
J.Am.Chem.Soc., 143, 2021
4J26
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BU of 4j26 by Molmil
Estrogen Receptor in complex with proline-flanked LXXLL peptides
Descriptor: 12-mer Peptide, ESTRADIOL, Estrogen receptor beta
Authors:Fuchs, S, Nguyen, H.D, Phan, T, Burton, M, Nieto, L, de Vries-van Leeuwen, I, Schmidt, A, Goodarzifard, M, Agten, S, Rose, R, Ottmann, C, Milroy, L.G, Brunsveld, L.
Deposit date:2013-02-04
Release date:2013-03-13
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Proline primed helix length as a modulator of the nuclear receptor-coactivator interaction
J.Am.Chem.Soc., 135, 2013
5MK4
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BU of 5mk4 by Molmil
Crystal structure of the Retinoid X Receptor alpha in complex with synthetic honokiol derivative 7 and a fragment of the TIF2 co-activator.
Descriptor: (~{E})-3-[3-(2-methyl-5-phenyl-phenyl)-4-oxidanyl-phenyl]prop-2-enoic acid, CHLORIDE ION, Nuclear receptor coactivator 2, ...
Authors:Andrei, S.A, Scheepstra, M, Brunsveld, L, Ottmann, C.
Deposit date:2016-12-02
Release date:2017-11-08
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2 Å)
Cite:Ligand Dependent Switch from RXR Homo- to RXR-NURR1 Heterodimerization.
ACS Chem Neurosci, 8, 2017
4DAT
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BU of 4dat by Molmil
Structure of 14-3-3 sigma in complex with PADI6 14-3-3 binding motif II
Descriptor: 14-3-3 protein sigma, MAGNESIUM ION, Peptidylarginine Deiminase type VI
Authors:Rose, R, Rose, M, Ottmann, C.
Deposit date:2012-01-13
Release date:2012-06-13
Last modified:2012-10-24
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Identification and structural characterization of two 14-3-3 binding sites in the human peptidylarginine deiminase type VI.
J.Struct.Biol., 180, 2012
4DHS
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BU of 4dhs by Molmil
Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening
Descriptor: (2-{2-[(3,5-dichlorophenyl)amino]-2-oxoethoxy}phenyl)phosphonic acid, 14-3-3 PROTEIN SIGMA, CHLORIDE ION, ...
Authors:Thiel, P, Roeglin, L, Kohlbacher, O, Ottmann, C.
Deposit date:2012-01-30
Release date:2013-07-31
Last modified:2013-09-04
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Virtual screening and experimental validation reveal novel small-molecule inhibitors of 14-3-3 protein-protein interactions.
Chem.Commun.(Camb.), 49, 2013
4DHN
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BU of 4dhn by Molmil
Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening
Descriptor: 14-3-3 protein sigma, CHLORIDE ION, GLYCEROL, ...
Authors:Thiel, P, Roeglin, L, Kohlbacher, O, Ottmann, C.
Deposit date:2012-01-30
Release date:2013-07-31
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Virtual screening and experimental validation reveal novel small-molecule inhibitors of 14-3-3 protein-protein interactions.
Chem.Commun.(Camb.), 49, 2013

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数据于2024-06-26公开中

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