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PDB: 127 件
4R07
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BU of 4r07 by Molmil
Crystal structure of human TLR8 in complex with ORN06
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3'-O-[(R)-{[(2R,3aR,4R,6R,6aR)-6-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-2-hydroxy-2-oxidotetrahydrofuro[3,4-d][1,3,2]dioxaphosphol-4-yl]methoxy}(hydroxy)phosphoryl]uridine 5'-(dihydrogen phosphate), ...
著者Tanji, H, Ohto, U, Shibata, T, Taoka, M, Yamauchi, Y, Isobe, T, Miyake, K, Shimizu, T.
登録日2014-07-30
公開日2015-01-14
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Toll-like receptor 8 senses degradation products of single-stranded RNA
Nat.Struct.Mol.Biol., 22, 2015
4R09
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BU of 4r09 by Molmil
Crystal structure of human TLR8 in complex with ORN06S
分子名称: 1-[(2R,3aR,4R,6R,6aR)-2-hydroxy-6-(hydroxymethyl)-2-sulfidotetrahydrofuro[3,4-d][1,3,2]dioxaphosphol-4-yl]pyrimidine-2,4(1H,3H)-dione, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Tanji, H, Ohto, U, Shimizu, T.
登録日2014-07-30
公開日2015-01-14
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.62 Å)
主引用文献Toll-like receptor 8 senses degradation products of single-stranded RNA.
Nat.Struct.Mol.Biol., 22, 2015
3WF2
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BU of 3wf2 by Molmil
Crystal structure of human beta-galactosidase in complex with NBT-DGJ
分子名称: (2R,3S,4R,5S)-N-butyl-3,4,5-trihydroxy-2-(hydroxymethyl)piperidine-1-carbothioamide, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Suzuki, H, Ohto, U, Shimizu, T.
登録日2013-07-16
公開日2014-04-16
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural basis of pharmacological chaperoning for human beta-galactosidase
to be published
3WF0
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BU of 3wf0 by Molmil
Crystal structure of human beta-galactosidase in complex with 6S-NBI-DGJ
分子名称: (3Z,6S,7R,8S,8aS)-3-(butylimino)hexahydro[1,3]thiazolo[3,4-a]pyridine-6,7,8-triol, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Suzuki, H, Ohto, U, Shimizu, T.
登録日2013-07-16
公開日2014-04-23
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural basis of pharmacological chaperoning for human beta-galactosidase
to be published
4ZLC
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BU of 4zlc by Molmil
Crystal structure of the ROQ domain of human Roquin-2
分子名称: Roquin-2
著者Sakurai, S, Ohto, U, Shimizu, T.
登録日2015-05-01
公開日2015-08-19
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structure of human Roquin-2 and its complex with constitutive-decay element RNA
Acta Crystallogr.,Sect.F, 71, 2015
4ZLD
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BU of 4zld by Molmil
Crystal structure of human Roquin-2 ROQ domain in complex with Roquin CDE RNA
分子名称: GLYCEROL, RNA (5'-R(*UP*AP*AP*CP*UP*UP*CP*UP*GP*UP*GP*AP*AP*GP*UP*UP*G)-3'), Roquin-2
著者Sakurai, S, Ohto, U, Shimizu, T.
登録日2015-05-01
公開日2015-08-19
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structure of human Roquin-2 and its complex with constitutive-decay element RNA
Acta Crystallogr.,Sect.F, 71, 2015
5AWB
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BU of 5awb by Molmil
Crystal structure of human TLR8 in complex with N1-3-aminomethylbenzyl (meta-amine)
分子名称: 1-[[3-(aminomethyl)phenyl]methyl]-2-butyl-imidazo[4,5-c]quinolin-4-amine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Tanji, H, Ohto, U, Shimizu, T.
登録日2015-07-03
公開日2015-09-23
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structure-Based Design of Human TLR8-Specific Agonists with Augmented Potency and Adjuvanticity.
J.Med.Chem., 58, 2015
5AWC
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BU of 5awc by Molmil
Crystal structure of human TLR8 in complex with MB-564
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-(4-azanylbutyl)-3-pentyl-quinolin-2-amine, ...
著者Tanji, H, Ohto, U, Shimizu, T.
登録日2015-07-03
公開日2016-07-20
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structure-based Design of Human TLR8-specific Agonists with Augmented Potency and Adjuvanticity
To Be Published
5AWA
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BU of 5awa by Molmil
Crystal structure of human TLR8 in complex with MB-568
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-[[3-(aminomethyl)phenyl]methyl]-3-pentyl-quinolin-2-amine, ...
著者Tanji, H, Ohto, U, Shimizu, T.
登録日2015-07-03
公開日2016-07-20
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structure-based Design of Human TLR8-specific Agonists with Augmented Potency and Adjuvanticity
To Be Published
7VAF
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BU of 7vaf by Molmil
Cryo-EM structure of Rat NTCP complexed with YN69202Fab
分子名称: Fab heavy chain from antibody IgG clone number YN69202, Fab light chain from antibody IgG clone number YN69202, Sodium/bile acid cotransporter
著者Asami, J, Shimizu, T, Ohto, U.
登録日2021-08-29
公開日2022-05-25
最終更新日2024-10-23
実験手法ELECTRON MICROSCOPY (3.11 Å)
主引用文献Structure of the bile acid transporter and HBV receptor NTCP.
Nature, 606, 2022
7VAG
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BU of 7vag by Molmil
Cryo-EM structure of human NTCP complexed with YN69202Fab in the presence of myristoylated preS1 peptide
分子名称: Fab heavy chain from antibody IgG clone number YN69202, Fab light chain from antibody IgG clone number YN69202, Sodium/bile acid cotransporter
著者Asami, J, Shimizu, T, Ohto, U.
登録日2021-08-29
公開日2022-05-25
最終更新日2024-10-30
実験手法ELECTRON MICROSCOPY (3.32 Å)
主引用文献Structure of the bile acid transporter and HBV receptor NTCP.
Nature, 606, 2022
7VAD
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BU of 7vad by Molmil
Cryo-EM structure of human NTCP complexed with YN69202Fab
分子名称: Fab heavy chain from antibody IgG clone number YN69202, Fab light chain from antibody IgG clone number YN69202, Sodium/bile acid cotransporter
著者Asami, J, Shimizu, T, Ohto, U.
登録日2021-08-29
公開日2022-05-25
最終更新日2024-10-09
実験手法ELECTRON MICROSCOPY (3.41 Å)
主引用文献Structure of the bile acid transporter and HBV receptor NTCP.
Nature, 606, 2022
7VAE
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BU of 7vae by Molmil
Cryo-EM structure of bovine NTCP complexed with YN69202Fab
分子名称: Fab heavy chain from antibody IgG clone number YN69202, Fab light chain from antibody IgG clone number YN69202, Solute carrier family 10 (Sodium/bile acid cotransporter family), ...
著者Asami, J, Shimizu, T, Ohto, U.
登録日2021-08-29
公開日2022-05-25
最終更新日2024-10-23
実験手法ELECTRON MICROSCOPY (3.55 Å)
主引用文献Structure of the bile acid transporter and HBV receptor NTCP.
Nature, 606, 2022
7VGR
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BU of 7vgr by Molmil
SARS-CoV-2 M protein dimer (long form) in complex with YN7756_1 Fab
分子名称: Membrane protein, YN7756_1 Fab heavy chain, YN7756_1 Fab light chain
著者Zhang, Z, Ohto, U, Shimizu, T.
登録日2021-09-18
公開日2022-08-03
最終更新日2024-10-30
実験手法ELECTRON MICROSCOPY (2.7 Å)
主引用文献Structure of SARS-CoV-2 membrane protein essential for virus assembly.
Nat Commun, 13, 2022
7VGS
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BU of 7vgs by Molmil
SARS-CoV-2 M protein dimer (short form) in complex with YN7717_9 Fab
分子名称: Membrane protein, YN7717_9 Fab heavy chain, YN7717_9 Fab light chain
著者Zhang, Z, Ohto, U, Shimizu, T.
登録日2021-09-18
公開日2022-08-03
最終更新日2023-08-16
実験手法ELECTRON MICROSCOPY (2.8 Å)
主引用文献Structure of SARS-CoV-2 membrane protein essential for virus assembly.
Nat Commun, 13, 2022
7WM4
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BU of 7wm4 by Molmil
Cryo-EM structure of tetrameric TLR3 in complex with dsRNA (90 bp)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, RNA (81-MER), ...
著者Sakaniwa, K, Ohto, U, Shimizu, T.
登録日2022-01-14
公開日2023-01-25
最終更新日2024-10-16
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献TLR3 forms a laterally aligned multimeric complex along double-stranded RNA for efficient signal transduction.
Nat Commun, 14, 2023
5GMH
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BU of 5gmh by Molmil
Crystal structure of monkey TLR7 in complex with R848
分子名称: 1-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-ol, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Zhang, Z, Ohto, U, Shimizu, T.
登録日2016-07-14
公開日2016-11-02
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural Analysis Reveals that Toll-like Receptor 7 Is a Dual Receptor for Guanosine and Single-Stranded RNA
Immunity, 45, 2016
5GMF
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BU of 5gmf by Molmil
Crystal structure of monkey TLR7 in complex with guanosine and polyU
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
著者Zhang, Z, Ohto, U, Shimizu, T.
登録日2016-07-14
公開日2016-11-02
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural Analysis Reveals that Toll-like Receptor 7 Is a Dual Receptor for Guanosine and Single-Stranded RNA
Immunity, 45, 2016
5IRN
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BU of 5irn by Molmil
Crystal structure of rabbit NOD2 in an ADP-bound state (Crystal form1)
分子名称: ADENOSINE-5'-DIPHOSPHATE, Uncharacterized protein
著者Maekawa, S, Ohto, U, Shimizu, T.
登録日2016-03-14
公開日2016-06-29
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.34 Å)
主引用文献Crystal structure of NOD2 and its implications in human disease.
Nat Commun, 7, 2016
5IRM
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BU of 5irm by Molmil
Crystal structure of rabbit NOD2 in an ADP-bound state (Crystal form2)
分子名称: ADENOSINE-5'-DIPHOSPHATE, Uncharacterized protein
著者Maekawa, S, Ohto, U, Shimizu, T.
登録日2016-03-14
公開日2016-06-29
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (3.31 Å)
主引用文献Crystal structure of NOD2 and its implications in human disease.
Nat Commun, 7, 2016
5HDH
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BU of 5hdh by Molmil
Crystal structure of human TLR8 with an uncleaved Z-loop
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Tanji, H, Ohto, U, Shimizu, T.
登録日2016-01-05
公開日2016-03-09
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Autoinhibition and relief mechanism by the proteolytic processing of Toll-like receptor 8
Proc.Natl.Acad.Sci.USA, 113, 2016
5GMG
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BU of 5gmg by Molmil
Crystal structure of monkey TLR7 in complex with loxoribine and polyU
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-azanyl-9-[(2~{R},3~{R},4~{S},5~{R})-5-(hydroxymethyl)-3,4-bis(oxidanyl)oxolan-2-yl]-7-prop-2-enyl-1~{H}-purine-6,8-dione, ...
著者Zhang, Z, Ohto, U, Shimizu, T.
登録日2016-07-14
公開日2016-11-02
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural Analysis Reveals that Toll-like Receptor 7 Is a Dual Receptor for Guanosine and Single-Stranded RNA
Immunity, 45, 2016
5IRL
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BU of 5irl by Molmil
Crystal structure of rabbit NOD2 SER mutant in an ADP-bound state
分子名称: ADENOSINE-5'-DIPHOSPHATE, Uncharacterized protein
著者Maekawa, S, Ohto, U, Shimizu, T.
登録日2016-03-14
公開日2016-06-29
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (3.09 Å)
主引用文献Crystal structure of NOD2 and its implications in human disease.
Nat Commun, 7, 2016
5Y7Y
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BU of 5y7y by Molmil
Crystal structure of AhRR/ARNT complex
分子名称: Aryl hydrocarbon receptor nuclear translocator, Aryl hydrocarbon receptor repressor, GLYCEROL
著者Sakurai, S, Shimizu, T, Ohto, U.
登録日2017-08-18
公開日2017-09-20
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献The crystal structure of the AhRR-ARNT heterodimer reveals the structural basis of the repression of AhR-mediated transcription.
J. Biol. Chem., 292, 2017
5Z15
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BU of 5z15 by Molmil
Crystal structure of human TLR8 in complex with CU-CPT9c
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(7-chloranylquinolin-4-yl)-2-methyl-phenol, ...
著者Tanji, H, Ohto, U, Shimizu, T.
登録日2017-12-25
公開日2018-07-04
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Inhibition of Toll-like Receptor 8 by Specifically Targeting a Unique Allosteric Site and Locking Its Resting State
To Be Published

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件を2024-11-06に公開中

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