4R09

Crystal structure of human TLR8 in complex with ORN06S

Summary for 4R09

Entry DOI	10.2210/pdb4r09/pdb
Related	4R07 4R08 4R0A
Descriptor	Toll-like receptor 8, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
Functional Keywords	leucine rich repeat, rna, glycosylation, innate immunity, rna recognition, ssrna, rna receptor, rna binding, antiviral binding, antitumor drug binding, immune system
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	383588.75
Authors	Tanji, H.,Ohto, U.,Shimizu, T. (deposition date: 2014-07-30, release date: 2015-01-14, Last modification date: 2020-07-29)
Primary citation	Tanji, H.,Ohto, U.,Shibata, T.,Taoka, M.,Yamauchi, Y.,Isobe, T.,Miyake, K.,Shimizu, T. Toll-like receptor 8 senses degradation products of single-stranded RNA. Nat.Struct.Mol.Biol., 22:109-115, 2015 Cited by PubMed: 25599397 DOI: 10.1038/nsmb.2943 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.62 Å)

Structure validation