4R09
Crystal structure of human TLR8 in complex with ORN06S
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Toll-like receptor 8 | polymer | 811 | 92835.4 | 4 | UniProt (Q9NR97) Pfam (PF13855) | Homo sapiens (human) | |
| 2 | E, K (E, K) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 2 | In PDB GlyTouCan (G22768VO) | |||
| 3 | F, G, I, J, M... (F, G, I, J, M...) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 6 | In PDB GlyTouCan (G42666HT) | |||
| 4 | H, L, N (H, L, N) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 3 | In PDB GlyTouCan (G15407YE) | |||
| 5 | AA, P, T, Z (D, A, B) | URIDINE | non-polymer | 244.2 | 4 | Chemie (URI) PubChem (1177) PubChem (6029) PubChem (18323) PubChem (177679014) PubChem (40428662) PubChem (44450699) PubChem (45356795) PubChem (45358305) PubChem (46780471) PubChem (46875324) PubChem (57157461) PubChem (57291238) PubChem (57416896) PubChem (66682873) PubChem (68438530) PubChem (68442208) PubChem (453551) PubChem (466466) PubChem (638039) PubChem (643973) PubChem (1521749) PubChem (170274) PubChem (89495556) PubChem (92131731) PubChem (6604651) PubChem (10169826) PubChem (11064619) PubChem (6559159) PubChem (7059436) PubChem (7059437) PubChem (7059438) PubChem (7059439) PubChem (119106346) PubChem (9859650) PubChem (12219138) PubChem (12219139) PubChem (130312966) PubChem (133687563) PubChem (134694357) PubChem (147417237) PubChem (164540240) PubChem (168266025) PubChem (171699408) | |||
| 6 | BA, Q, U, X (D, A, B, C) | O-[(2R,3S,4R,5R)-5-(2-amino-6-oxo-3,6-dihydro-9H-purin-9-yl)-2-({[(S)-({(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-hydroxy-2-[(thiophosphonooxy)methyl]tetrahydrofuran-3-yl}oxy)(sulfanyl)phosphoryl]oxy}methyl)-4-hydroxytetrahydrofuran-3-yl] dihydrogen (S)-phosphorothioate | non-polymer | 797.6 | 4 | Chemie (06S) | |||
| 7 | CA, R, V, Y (D, A, B, C) | 1-[(2R,3aR,4R,6R,6aR)-2-hydroxy-6-(hydroxymethyl)-2-sulfidotetrahydrofuro[3,4-d][1,3,2]dioxaphosphol-4-yl]pyrimidine-2,4(1H,3H)-dione | non-polymer | 322.2 | 4 | Chemie (UPT) PubChem (6913638) PubChem (139033552) | |||
| 8 | DA, S, W (D, A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) |
Sequence modifications
A, B, C, D: 26 - 827 (UniProt: Q9NR97)
| PDB | External Database | Details |
|---|---|---|
| Arg 22 | - | expression tag |
| Ser 23 | - | expression tag |
| Pro 24 | - | expression tag |
| Trp 25 | - | expression tag |
| Glu 828 | - | expression tag |
| Phe 829 | - | expression tag |
| Leu 830 | - | expression tag |
| Val 831 | - | expression tag |
| Pro 832 | - | expression tag |
| Arg 833 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 371341.5 | |
| Branched | Number of molecules | 11 |
| Total formula weight | 6127.7 | |
| Non-Polymers* | Number of molecules | 15 |
| Total formula weight | 6119.6 | |
| All* | Total formula weight | 383588.8 |
