4R09
Crystal structure of human TLR8 in complex with ORN06S
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Toll-like receptor 8 | polymer | 811 | 92835.4 | 4 | UniProt (Q9NR97) Pfam (PF13855) In PDB | Homo sapiens (human) | |
2 | E, K | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 2 | In PDB GlyTouCan (G22768VO) | |||
3 | F, G, I, J, M... | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 6 | In PDB GlyTouCan (G42666HT) | |||
4 | H, L, N | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 3 | In PDB GlyTouCan (G15407YE) | |||
5 | D, A, B | URIDINE | non-polymer | 244.2 | 4 | Chemie (URI) | |||
6 | D, A, B, C | O-[(2R,3S,4R,5R)-5-(2-amino-6-oxo-3,6-dihydro-9H-purin-9-yl)-2-({[(S)-({(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-hydroxy-2-[(thiophosphonooxy)methyl]tetrahydrofuran-3-yl}oxy)(sulfanyl)phosphoryl]oxy}methyl)-4-hydroxytetrahydrofuran-3-yl] dihydrogen (S)-phosphorothioate | non-polymer | 797.6 | 4 | Chemie (06S) | |||
7 | D, A, B, C | 1-[(2R,3aR,4R,6R,6aR)-2-hydroxy-6-(hydroxymethyl)-2-sulfidotetrahydrofuro[3,4-d][1,3,2]dioxaphosphol-4-yl]pyrimidine-2,4(1H,3H)-dione | non-polymer | 322.2 | 4 | Chemie (UPT) | |||
8 | D, A, B | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) |
Sequence modifications
A, B, C, D: 26 - 827 (UniProt: Q9NR97)
PDB | External Database | Details |
---|---|---|
Arg 22 | - | expression tag |
Ser 23 | - | expression tag |
Pro 24 | - | expression tag |
Trp 25 | - | expression tag |
Glu 828 | - | expression tag |
Phe 829 | - | expression tag |
Leu 830 | - | expression tag |
Val 831 | - | expression tag |
Pro 832 | - | expression tag |
Arg 833 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 371341.5 | |
Branched | Number of molecules | 11 |
Total formula weight | 6127.7 | |
Non-Polymers* | Number of molecules | 15 |
Total formula weight | 6119.6 | |
All* | Total formula weight | 383588.8 |