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PDB: 126 件
4G8A
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BU of 4g8a by Molmil
Crystal structure of human TLR4 polymorphic variant D299G and T399I in complex with MD-2 and LPS
分子名称: (R)-((2R,3S,4R,5R,6R)-3-HYDROXY-2-(HYDROXYMETHYL)-5-((R)-3-HYDROXYTETRADECANAMIDO)-6-(PHOSPHONOOXY)TETRAHYDRO-2H-PYRAN-4-YL) 3-HYDROXYTETRADECANOATE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Ohto, U, Shimizu, T.
登録日2012-07-23
公開日2012-10-17
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural analyses of human Toll-like receptor 4 polymorphisms D299G and T399I
J.Biol.Chem., 287, 2012
1UJ3
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Crystal structure of a humanized Fab fragment of anti-tissue-factor antibody in complex with tissue factor
分子名称: IgG Fab heavy chain, IgG Fab light chain, tissue factor
著者Ohto, U, Mizutani, R, Nakamura, M, Adachi, H, Satow, Y.
登録日2003-07-25
公開日2004-07-25
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal structure of a humanized Fab fragment of anti-tissue-factor antibody in complex with tissue factor.
J.Synchrotron Radiat., 11, 2004
8WX5
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BU of 8wx5 by Molmil
Cryo-EM structure of human SLC15A4 in complex with TASL (inward-facing open)
分子名称: Solute carrier family 15 member 4, TASL (TASL-SLC15A4 fusion protein)
著者Ohto, U, Zhang, Z, Fujimura, A, Shimizu, T.
登録日2023-10-27
公開日2023-12-13
実験手法ELECTRON MICROSCOPY (3.91 Å)
主引用文献Cryo-EM structure of human SLC15A4 in complex with TASL (inward-facing open)
To Be Published
2E59
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BU of 2e59 by Molmil
Crystal structure of human MD-2 in complex with lipid IVa
分子名称: (R)-((2R,3S,4R,5R,6R)-3-HYDROXY-2-(HYDROXYMETHYL)-5-((R)-3-HYDROXYTETRADECANAMIDO)-6-(PHOSPHONOOXY)TETRAHYDRO-2H-PYRAN-4-YL) 3-HYDROXYTETRADECANOATE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-deoxy-3-O-[(3R)-3-hydroxytetradecanoyl]-2-{[(3R)-3-hydroxytetradecanoyl]amino}-4-O-phosphono-beta-D-glucopyranose, ...
著者Ohto, U, Satow, Y.
登録日2006-12-19
公開日2007-06-26
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.21 Å)
主引用文献Crystal structures of human MD-2 and its complex with antiendotoxic lipid IVa
Science, 316, 2007
2E56
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Crystal structure of human MD-2
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Lymphocyte antigen 96, MYRISTIC ACID
著者Ohto, U, Satow, Y.
登録日2006-12-19
公開日2007-06-26
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structures of human MD-2 and its complex with antiendotoxic lipid IVa.
Science, 316, 2007
7VTQ
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BU of 7vtq by Molmil
Cryo-EM structure of mouse NLRP3 (full-length) dodecamer
分子名称: 1-[4-(2-oxidanylpropan-2-yl)furan-2-yl]sulfonyl-3-(1,2,3,5-tetrahydro-s-indacen-4-yl)urea, ADENOSINE-5'-DIPHOSPHATE, NACHT, ...
著者Ohto, U, Shimizu, T.
登録日2021-10-30
公開日2022-03-09
最終更新日2022-03-23
実験手法ELECTRON MICROSCOPY (3.55 Å)
主引用文献Structural basis for the oligomerization-mediated regulation of NLRP3 inflammasome activation.
Proc.Natl.Acad.Sci.USA, 119, 2022
7VTP
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BU of 7vtp by Molmil
Cryo-EM structure of PYD-deleted human NLRP3 hexamer
分子名称: 1-[4-(2-oxidanylpropan-2-yl)furan-2-yl]sulfonyl-3-(1,2,3,5-tetrahydro-s-indacen-4-yl)urea, ADENOSINE-5'-DIPHOSPHATE, NACHT, ...
著者Ohto, U, Shimizu, T.
登録日2021-10-30
公開日2022-03-09
最終更新日2024-06-26
実験手法ELECTRON MICROSCOPY (3.23 Å)
主引用文献Structural basis for the oligomerization-mediated regulation of NLRP3 inflammasome activation.
Proc.Natl.Acad.Sci.USA, 119, 2022
3B2D
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BU of 3b2d by Molmil
Crystal structure of human RP105/MD-1 complex
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CD180 antigen, ...
著者Ohto, U, Shimizu, T.
登録日2011-07-29
公開日2011-11-09
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal Structures of Mouse and Human RP105/MD-1 Complexes Reveal Unique Dimer Organization of the Toll-Like Receptor Family.
J.Mol.Biol., 413, 2011
7C77
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BU of 7c77 by Molmil
Cryo-EM structure of mouse TLR3 in complex with UNC93B1
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Protein unc-93 homolog B1, ...
著者Ohto, U, Ishida, H, Shimizu, T.
登録日2020-05-23
公開日2021-01-06
最終更新日2021-02-24
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Cryo-EM structures of Toll-like receptors in complex with UNC93B1.
Nat.Struct.Mol.Biol., 28, 2021
7CYN
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BU of 7cyn by Molmil
Cryo-EM structure of human TLR7 in complex with UNC93B1
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Protein unc-93 homolog B1, ...
著者Ohto, U, Ishida, H, Shimizu, T.
登録日2020-09-03
公開日2021-01-06
最終更新日2021-02-24
実験手法ELECTRON MICROSCOPY (4.2 Å)
主引用文献Cryo-EM structures of Toll-like receptors in complex with UNC93B1.
Nat.Struct.Mol.Biol., 28, 2021
7C76
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BU of 7c76 by Molmil
Cryo-EM structure of human TLR3 in complex with UNC93B1
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Protein unc-93 homolog B1, ...
著者Ohto, U, Ishida, H, Shimizu, T.
登録日2020-05-23
公開日2021-01-06
最終更新日2021-02-24
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Cryo-EM structures of Toll-like receptors in complex with UNC93B1.
Nat.Struct.Mol.Biol., 28, 2021
5Y3J
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BU of 5y3j by Molmil
Crystal structure of horse TLR9 in complex with two DNAs (CpG DNA and TCGCAC DNA)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DNA (5'-D(*AP*GP*GP*CP*GP*TP*TP*TP*TP*T)-3'), ...
著者Ohto, U, Ishida, H, Shimizu, T.
登録日2017-07-29
公開日2018-04-18
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.81 Å)
主引用文献Toll-like Receptor 9 Contains Two DNA Binding Sites that Function Cooperatively to Promote Receptor Dimerization and Activation
Immunity, 48, 2018
5Y3K
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BU of 5y3k by Molmil
Crystal structure of horse TLR9 in complex with two DNAs (CpG DNA and GCGCAC DNA)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DNA (5'-D(*AP*GP*GP*CP*GP*TP*TP*TP*TP*T)-3'), ...
著者Ohto, U, Shimizu, T.
登録日2017-07-29
公開日2018-04-18
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Toll-like Receptor 9 Contains Two DNA Binding Sites that Function Cooperatively to Promote Receptor Dimerization and Activation
Immunity, 48, 2018
5Y3M
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BU of 5y3m by Molmil
Crystal structure of bovine TLR9 in complex with two DNAs (CpG DNA and TCGTTT DNA)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, DNA (5'-D(*TP*CP*GP*T)-3'), DNA (5'-D(P*GP*GP*CP*GP*TP*T)-3'), ...
著者Ohto, U, Shimizu, T.
登録日2017-07-29
公開日2018-04-18
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Toll-like Receptor 9 Contains Two DNA Binding Sites that Function Cooperatively to Promote Receptor Dimerization and Activation
Immunity, 48, 2018
5Y3L
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BU of 5y3l by Molmil
Crystal structure of horse TLR9 in complex with two DNAs (CpG DNA and CCGCAC DNA)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DNA (5'-D(*AP*GP*GP*CP*GP*TP*TP*TP*TP*T)-3'), ...
著者Ohto, U, Shimizu, T.
登録日2017-07-29
公開日2018-04-18
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Toll-like Receptor 9 Contains Two DNA Binding Sites that Function Cooperatively to Promote Receptor Dimerization and Activation
Immunity, 48, 2018
5JKC
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BU of 5jkc by Molmil
Crystal structure of human IZUMO1-JUNO complex (crystal form 1)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Izumo sperm-egg fusion protein 1, ...
著者Ohto, U, Ishida, H, Shimizu, T.
登録日2016-04-26
公開日2016-06-22
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structure of IZUMO1-JUNO reveals sperm-oocyte recognition during mammalian fertilization
Nature, 534, 2016
5JKD
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BU of 5jkd by Molmil
Crystal structure of human IZUMO1-JUNO complex (crystal form 2)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Izumo sperm-egg fusion protein 1, ...
著者Ohto, U, Ishida, H, Shimizu, T.
登録日2016-04-26
公開日2016-06-22
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structure of IZUMO1-JUNO reveals sperm-oocyte recognition during mammalian fertilization
Nature, 534, 2016
5JKE
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BU of 5jke by Molmil
Crystal structure of human IZUMO1-JUNO complex (crystal form 3)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Izumo sperm-egg fusion protein 1, ...
著者Ohto, U, Ishida, H, Shimizu, T.
登録日2016-04-26
公開日2016-06-22
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.86 Å)
主引用文献Structure of IZUMO1-JUNO reveals sperm-oocyte recognition during mammalian fertilization
Nature, 534, 2016
5JKB
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BU of 5jkb by Molmil
Crystal structure of human JUNO (crystal form 2)
分子名称: CHLORIDE ION, Sperm-egg fusion protein Juno
著者Ohto, U, Ishida, H, Shimizu, T.
登録日2016-04-26
公開日2016-06-22
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (3.23 Å)
主引用文献Structure of IZUMO1-JUNO reveals sperm-oocyte recognition during mammalian fertilization
Nature, 534, 2016
5JKA
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BU of 5jka by Molmil
Crystal structure of human JUNO (crystal form 1)
分子名称: CHLORIDE ION, Sperm-egg fusion protein Juno, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
著者Ohto, U, Ishida, H, Shimizu, T.
登録日2016-04-26
公開日2016-06-22
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structure of IZUMO1-JUNO reveals sperm-oocyte recognition during mammalian fertilization
Nature, 534, 2016
5JK9
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BU of 5jk9 by Molmil
Crystal structure of human IZUMO1
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Izumo sperm-egg fusion protein 1
著者Ohto, U, Ishida, H, Shimizu, T.
登録日2016-04-26
公開日2016-06-22
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structure of IZUMO1-JUNO reveals sperm-oocyte recognition during mammalian fertilization
Nature, 534, 2016
3T6Q
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BU of 3t6q by Molmil
Crystal structure of mouse RP105/MD-1 complex
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CD180 antigen, ...
著者Ohto, U, Shimizu, T.
登録日2011-07-28
公開日2011-11-09
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal Structures of Mouse and Human RP105/MD-1 Complexes Reveal Unique Dimer Organization of the Toll-Like Receptor Family.
J.Mol.Biol., 413, 2011
3THC
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BU of 3thc by Molmil
Crystal structure of human beta-galactosidase in complex with galactose
分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-galactosidase, ...
著者Ohto, U, Shimizu, T.
登録日2011-08-18
公開日2011-12-07
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal structure of human beta-galactosidase: structural basis of Gm1 gangliosidosis and morquio B diseases
J.Biol.Chem., 287, 2012
3THD
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Crystal structure of human beta-galactosidase in complex with 1-deoxygalactonojirimycin
分子名称: (2R,3S,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-triol, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Ohto, U, Shimizu, T.
登録日2011-08-18
公開日2011-12-07
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.79 Å)
主引用文献Crystal structure of human beta-galactosidase: structural basis of Gm1 gangliosidosis and morquio B diseases
J.Biol.Chem., 287, 2012
3VQ1
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BU of 3vq1 by Molmil
Crystal structure of mouse TLR4/MD-2/lipid IVa complex
分子名称: (R)-((2R,3S,4R,5R,6R)-3-HYDROXY-2-(HYDROXYMETHYL)-5-((R)-3-HYDROXYTETRADECANAMIDO)-6-(PHOSPHONOOXY)TETRAHYDRO-2H-PYRAN-4-YL) 3-HYDROXYTETRADECANOATE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Ohto, U, Shimizu, T.
登録日2012-03-17
公開日2012-05-09
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structural basis of species-specific endotoxin sensing by innate immune receptor TLR4/MD-2
Proc.Natl.Acad.Sci.USA, 109, 2012

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