7VPL
 
 | | Cryo-EM structure of the human ATP13A2 (SPM-bound E2Pi state) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, MAGNESIUM ION, Polyamine-transporting ATPase 13A2, ... | | 著者 | Tomita, A, Yamashita, K, Nishizawa, T, Nureki, O. | | 登録日 | 2021-10-17 | | 公開日 | 2021-12-29 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Cryo-EM reveals mechanistic insights into lipid-facilitated polyamine export by human ATP13A2.
Mol.Cell, 81, 2021
|
|
6LMW
 | | Cryo-EM structure of the CALHM chimeric construct (8-mer) | | 分子名称: | Calcium homeostasis modulator 1,Calcium homeostasis modulator protein 2 | | 著者 | Demura, K, Kusakizako, T, Shihoya, W, Hiraizumi, M, Shimada, H, Yamashita, K, Nishizawa, T, Nureki, O. | | 登録日 | 2019-12-26 | | 公開日 | 2020-07-29 | | 最終更新日 | 2020-09-09 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Cryo-EM structures of calcium homeostasis modulator channels in diverse oligomeric assemblies.
Sci Adv, 6, 2020
|
|
7VPI
 | | Cryo-EM structure of the human ATP13A2 (E1-ATP state) | | 分子名称: | MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, Polyamine-transporting ATPase 13A2 | | 著者 | Tomita, A, Yamashita, K, Nishizawa, T, Nureki, O. | | 登録日 | 2021-10-17 | | 公開日 | 2021-12-29 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Cryo-EM reveals mechanistic insights into lipid-facilitated polyamine export by human ATP13A2.
Mol.Cell, 81, 2021
|
|
6LPJ
 | | A2AR crystallized in EROCOC17+4, LCP-SFX at 277 K | | 分子名称: | 4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol, Adenosine receptor A2a,Soluble cytochrome b562,Adenosine receptor A2a, CHOLESTEROL, ... | | 著者 | Ihara, K, Hato, M, Nakane, T, Yamashita, K, Kimura-Someya, T, Hosaka, T, Ishizuka-Katsura, Y, Tanaka, R, Tanaka, T, Sugahara, M, Hirata, K, Yamamoto, M, Nureki, O, Tono, K, Nango, E, Iwata, S, Shirouzu, M. | | 登録日 | 2020-01-10 | | 公開日 | 2020-11-25 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Isoprenoid-chained lipid EROCOC 17+4 : a new matrix for membrane protein crystallization and a crystal delivery medium in serial femtosecond crystallography.
Sci Rep, 10, 2020
|
|
7VPJ
 | | Cryo-EM structure of the human ATP13A2 (E1P-ADP state) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Tomita, A, Yamashita, K, Nishizawa, T, Nureki, O. | | 登録日 | 2021-10-17 | | 公開日 | 2021-12-29 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Cryo-EM reveals mechanistic insights into lipid-facilitated polyamine export by human ATP13A2.
Mol.Cell, 81, 2021
|
|
7WN9
 | |
6JMH
 | | Structure of the Oxomolybdenum Mesoporphyrin IX-Reconstituted CYP102A1 Haem Domain with N-Abietoyl-L-Tryptophan | | 分子名称: | (2S)-2-[[(1R,4aR,4bR,10aR)-1,4a-dimethyl-7-propan-2-yl-2,3,4,4b,5,6,10,10a-octahydrophenanthren-1-yl]carbonylamino]-3-( 1H-indol-3-yl)propanoic acid, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Bifunctional cytochrome P450/NADPH--P450 reductase, ... | | 著者 | Stanfield, J.K, Omura, K, Kasai, C, Sugimoto, H, Shiro, Y, Watanabe, Y, Shoji, O. | | 登録日 | 2019-03-10 | | 公開日 | 2020-03-18 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.46 Å) | | 主引用文献 | Crystals in Minutes: Instant On-Site Microcrystallisation of Various Flavours of the CYP102A1 (P450BM3) Haem Domain.
Angew.Chem.Int.Ed.Engl., 59, 2020
|
|
2GKL
 | | Crystal structure of the zinc carbapenemase CPHA in complex with the inhibitor pyridine-2,4-dicarboxylate | | 分子名称: | Beta-lactamase, GLYCEROL, PYRIDINE-2,4-DICARBOXYLIC ACID, ... | | 著者 | Garau, G, Dideberg, O. | | 登録日 | 2006-04-03 | | 公開日 | 2007-03-13 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | | 主引用文献 | Competitive Inhibitors of the CphA Metallo-{beta}-Lactamase from Aeromonas hydrophila
Antimicrob.Agents Chemother., 51, 2007
|
|
7V6B
 | | Structure of the Dicer-2-R2D2 heterodimer | | 分子名称: | Dicer-2, isoform A, R2D2 | | 著者 | Yamaguchi, S, Nishizawa, T, Kusakizako, T, Yamashita, K, Tomita, A, Hirano, H, Nishimasu, H, Nureki, O. | | 登録日 | 2021-08-20 | | 公開日 | 2022-03-23 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Structure of the Dicer-2-R2D2 heterodimer bound to a small RNA duplex.
Nature, 607, 2022
|
|
7V6C
 | | Structure of the Dicer-2-R2D2 heterodimer bound to small RNA duplex | | 分子名称: | Dicer-2, isoform A, R2D2, ... | | 著者 | Yamaguchi, S, Nishizawa, T, Kusakizako, T, Yamashita, K, Tomita, A, Hirano, H, Nishimasu, H, Nureki, O. | | 登録日 | 2021-08-20 | | 公開日 | 2022-03-23 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Structure of the Dicer-2-R2D2 heterodimer bound to a small RNA duplex.
Nature, 607, 2022
|
|
6M8N
 | | Endo-fucoidan hydrolase P5AFcnA from glycoside hydrolase family 107 | | 分子名称: | CALCIUM ION, MALONATE ION, P5AFcnA | | 著者 | Boraston, A.B, Vickers, C.J, Abe, K, Salama-Alber, O. | | 登録日 | 2018-08-22 | | 公開日 | 2018-10-03 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | Endo-fucoidan hydrolases from glycoside hydrolase family 107 (GH107) display structural and mechanistic similarities to alpha-l-fucosidases from GH29.
J. Biol. Chem., 293, 2018
|
|
7V94
 | | Cryo-EM structure of the Cas12c2-sgRNA-target DNA ternary complex | | 分子名称: | Cas12c2, sgRNA, target DNA (non target strand), ... | | 著者 | Kurihara, N, Hirano, H, Tomita, A, Kobayashi, K, Kusakizako, T, Nishizawa, T, Yamashita, K, Nishimasu, H, Nureki, O. | | 登録日 | 2021-08-24 | | 公開日 | 2022-04-13 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Structure of the type V-C CRISPR-Cas effector enzyme.
Mol.Cell, 82, 2022
|
|
7V93
 | | Cryo-EM structure of the Cas12c2-sgRNA binary complex | | 分子名称: | cas12c2, sgRNA | | 著者 | Kurihara, N, Hirano, H, Tomita, A, Kobayashi, K, Kusakizako, T, Nishizawa, T, Yamashita, K, Nishimasu, H, Nureki, O. | | 登録日 | 2021-08-24 | | 公開日 | 2022-04-13 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Structure of the type V-C CRISPR-Cas effector enzyme.
Mol.Cell, 82, 2022
|
|
6LPL
 | | A2AR crystallized in EROCOC17+4, SS-ROX at 100 K | | 分子名称: | 4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol, Adenosine receptor A2a,Soluble cytochrome b562,Adenosine receptor A2a, CHOLESTEROL, ... | | 著者 | Ihara, K, Hato, M, Nakane, T, Yamashita, K, Kimura-Someya, T, Hosaka, T, Ishizuka-Katsura, Y, Tanaka, R, Tanaka, T, Sugahara, M, Hirata, K, Yamamoto, M, Nureki, O, Tono, K, Nango, E, Iwata, S, Shirouzu, M. | | 登録日 | 2020-01-11 | | 公開日 | 2020-11-25 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Isoprenoid-chained lipid EROCOC 17+4 : a new matrix for membrane protein crystallization and a crystal delivery medium in serial femtosecond crystallography.
Sci Rep, 10, 2020
|
|
7Y1G
 | | Crystal structure of human PRKACA complexed with DS01080522 | | 分子名称: | 1-chloranyl-~{N}-[(~{S})-(3-chloranyl-4-cyano-phenyl)-[(2~{R},4~{S})-4-oxidanylpyrrolidin-2-yl]methyl]-7-methoxy-isoquinoline-6-carboxamide, ZINC ION, cAMP-dependent protein kinase catalytic subunit alpha | | 著者 | Suzuki, M, Ubukata, O, Toyoda, A. | | 登録日 | 2022-06-08 | | 公開日 | 2022-09-28 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Novel protein kinase cAMP-Activated Catalytic Subunit Alpha (PRKACA) inhibitor shows anti-tumor activity in a fibrolamellar hepatocellular carcinoma model.
Biochem.Biophys.Res.Commun., 621, 2022
|
|
6K7N
 | | Cryo-EM structure of the human P4-type flippase ATP8A1-CDC50 (E1P state) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, Cell cycle control protein 50A, ... | | 著者 | Hiraizumi, M, Yamashita, K, Nishizawa, T, Nureki, O. | | 登録日 | 2019-06-07 | | 公開日 | 2019-08-28 | | 最終更新日 | 2021-02-10 | | 実験手法 | ELECTRON MICROSCOPY (2.84 Å) | | 主引用文献 | Cryo-EM structures capture the transport cycle of the P4-ATPase flippase.
Science, 365, 2019
|
|
6K7J
 | | Cryo-EM structure of the human P4-type flippase ATP8A1-CDC50 (E1-ATP state class1) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, Cell cycle control protein 50A, ... | | 著者 | Hiraizumi, M, Yamashita, K, Nishizawa, T, Nureki, O. | | 登録日 | 2019-06-07 | | 公開日 | 2019-08-28 | | 最終更新日 | 2021-02-10 | | 実験手法 | ELECTRON MICROSCOPY (3.08 Å) | | 主引用文献 | Cryo-EM structures capture the transport cycle of the P4-ATPase flippase.
Science, 365, 2019
|
|
7VM1
 | | Crystal Structure of HasAp Capturing Iron Tetra(4-pyridyl)porphyrin | | 分子名称: | Fe-Tetra(4-pyridyl)porphyrin, GLYCEROL, Heme acquisition protein HasAp | | 著者 | Shisaka, Y, Ueda, G, Sakakibara, E, Sugimoto, H, Shoji, O. | | 登録日 | 2021-10-06 | | 公開日 | 2022-08-17 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Tetraphenylporphyrin Enters the Ring: First Example of a Complex between Highly Bulky Porphyrins and a Protein.
Chembiochem, 23, 2022
|
|
6LMT
 | | Cryo-EM structure of the killifish CALHM1 | | 分子名称: | CHOLESTEROL HEMISUCCINATE, Calcium homeostasis modulator 1 | | 著者 | Demura, K, Kusakizako, T, Shihoya, W, Hiraizumi, M, Shimada, H, Yamashita, K, Nishizawa, T, Nureki, O. | | 登録日 | 2019-12-26 | | 公開日 | 2020-07-29 | | 最終更新日 | 2020-09-09 | | 実験手法 | ELECTRON MICROSCOPY (2.66 Å) | | 主引用文献 | Cryo-EM structures of calcium homeostasis modulator channels in diverse oligomeric assemblies.
Sci Adv, 6, 2020
|
|
1FFU
 | | CARBON MONOXIDE DEHYDROGENASE FROM HYDROGENOPHAGA PSEUDOFLAVA WHICH LACKS THE MO-PYRANOPTERIN MOIETY OF THE MOLYBDENUM COFACTOR | | 分子名称: | CUTL, MOLYBDOPROTEIN OF CARBON MONOXIDE DEHYDROGENASE, CUTM, ... | | 著者 | Haenzelmann, P, Dobbek, H, Gremer, L, Huber, R, Meyer, O. | | 登録日 | 2000-07-26 | | 公開日 | 2000-09-15 | | 最終更新日 | 2022-12-21 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | The effect of intracellular molybdenum in Hydrogenophaga pseudoflava on the crystallographic structure of the seleno-molybdo-iron-sulfur flavoenzyme carbon monoxide dehydrogenase.
J.Mol.Biol., 301, 2000
|
|
6K4J
 | | Crystal Structure of the the CD9 | | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, CD9 antigen, NICKEL (II) ION, ... | | 著者 | Umeda, R, Nishizawa, T, Sato, K, Nureki, O. | | 登録日 | 2019-05-24 | | 公開日 | 2020-05-13 | | 実験手法 | X-RAY DIFFRACTION (2.701 Å) | | 主引用文献 | Structural insights into tetraspanin CD9 function.
Nat Commun, 11, 2020
|
|
6K3Q
 | | Crystal Structure of P450BM3 with N-(3-cyclohexylpropanoyl)-L-prolyl-L-phenylalanine | | 分子名称: | (2S)-2-[[(2S)-1-(3-cyclohexylpropanoyl)pyrrolidin-2-yl]carbonylamino]-3-phenyl-propanoic acid, Bifunctional cytochrome P450/NADPH--P450 reductase, DIMETHYL SULFOXIDE, ... | | 著者 | Shoji, O, Yonemura, K. | | 登録日 | 2019-05-21 | | 公開日 | 2020-05-27 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.06 Å) | | 主引用文献 | Systematic Evolution of Decoy Molecules for the Highly Efficient Hydroxylation of Benzene and Small Alkanes Catalyzed by Wild-Type Cytochrome P450BM3
Acs Catalysis, 10, 2020
|
|
1U7J
 | | Solution structure of a diiron protein model | | 分子名称: | Four-helix bundle model, ZINC ION | | 著者 | Maglio, O, Nastri, F, Calhoun, J.R, Lahr, S, Pavone, V, DeGrado, W.F, Lombardi, A. | | 登録日 | 2004-08-04 | | 公開日 | 2005-03-01 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Analysis and Design of Turns in alpha-Helical Hairpins
J.Mol.Biol., 346, 2005
|
|
7ZDM
 | | Complex I from Ovis aries at pH5.5, Closed state | | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, ... | | 著者 | Sazanov, L, Petrova, O. | | 登録日 | 2022-03-29 | | 公開日 | 2022-09-21 | | 最終更新日 | 2022-10-05 | | 実験手法 | ELECTRON MICROSCOPY (3.44 Å) | | 主引用文献 | A universal coupling mechanism of respiratory complex I.
Nature, 609, 2022
|
|
7ZDP
 | | Complex I from Ovis aries at pH9, Open state | | 分子名称: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, ADENOSINE MONOPHOSPHATE, Acyl carrier protein, ... | | 著者 | Sazanov, L, Petrova, O. | | 登録日 | 2022-03-29 | | 公開日 | 2022-09-21 | | 最終更新日 | 2022-10-05 | | 実験手法 | ELECTRON MICROSCOPY (3.88 Å) | | 主引用文献 | A universal coupling mechanism of respiratory complex I.
Nature, 609, 2022
|
|
