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PDB: 36 件
4Q18
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BU of 4q18 by Molmil
Human dCK C4S-S74E mutant in complex with UDP and the inhibitor 4 [1-[5-(4-{[(2,6-diaminopyrimidin-4-yl)sulfanyl]methyl}-5-propyl-1,3-thiazol-2-yl)-2-methoxyphenoxy]-2-methylpropan-2-ol]
分子名称: 1-(5-(4-(((2,6-diaminopyrimidin-4-yl)thio)methyl)-5-propylthiazol-2-yl)-2-methoxyphenoxy)-2-methylpropan-2-ol, Deoxycytidine kinase, URIDINE-5'-DIPHOSPHATE
著者Nomme, J, Lavie, A.
登録日2014-04-03
公開日2014-11-05
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structure-guided development of deoxycytidine kinase inhibitors with nanomolar affinity and improved metabolic stability.
J.Med.Chem., 57, 2014
4YYX
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BU of 4yyx by Molmil
Crystal structure of the ZO-1 PDZ1 domain in complex with the 7-mer Claudin2 C-terminal tail
分子名称: FORMIC ACID, Tight junction protein ZO-1 fused with Claudin-2 C-terminal
著者Nomme, J, Lavie, A.
登録日2015-03-24
公開日2015-04-01
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.79 Å)
主引用文献Structural Basis of a Key Factor Regulating the Affinity between the Zonula Occludens First PDZ Domain and Claudins.
J.Biol.Chem., 290, 2015
8C4Z
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BU of 8c4z by Molmil
ProteinT protease, inactive mutant S224A
分子名称: CALCIUM ION, Extracellular serine proteinase, GLYCEROL, ...
著者Nomme, J, Gavalda, S, Cioci, G, Guicherd, M, Marty, A, Duquesne, S, Ben Khaled, M.
登録日2023-01-05
公開日2024-07-17
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (1.47 Å)
主引用文献An engineered enzyme embedded into PLA to make self-biodegradable plastic.
Nature, 631, 2024
8C4X
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BU of 8c4x by Molmil
PAM Protease
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, ...
著者Nomme, J, Gavalda, S, Cioci, G, Guicherd, M, Marty, A, Duquesne, S, Ben Khaled, M.
登録日2023-01-05
公開日2024-07-17
最終更新日2024-08-07
実験手法X-RAY DIFFRACTION (1.52 Å)
主引用文献An engineered enzyme embedded into PLA to make self-biodegradable plastic.
Nature, 631, 2024
6THS
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BU of 6ths by Molmil
High resolution crystal structure of Leaf-branch cutinase S165A variant
分子名称: 1,4-DIETHYLENE DIOXIDE, LCC
著者Nomme, J.
登録日2019-11-21
公開日2020-04-22
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (1.1 Å)
主引用文献An engineered PET depolymerase to break down and recycle plastic bottles.
Nature, 580, 2020
6THT
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BU of 6tht by Molmil
High resolution crystal structure of a Leaf-branch compost cutinase quintuple variant
分子名称: CITRIC ACID, GLYCEROL, IMIDAZOLE, ...
著者Nomme, J.
登録日2019-11-21
公開日2020-04-15
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.14 Å)
主引用文献An engineered PET depolymerase to break down and recycle plastic bottles.
Nature, 580, 2020
3TSZ
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BU of 3tsz by Molmil
crystal structure of PDZ3-SH3-GUK core module from human ZO-1 in complex with 12mer peptide from human JAM-A cytoplasmic tail
分子名称: Junctional adhesion molecule A, Tight junction protein ZO-1
著者Nomme, J, Lavie, A.
登録日2011-09-13
公開日2011-10-12
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.502 Å)
主引用文献The Src Homology 3 Domain Is Required for Junctional Adhesion Molecule Binding to the Third PDZ Domain of the Scaffolding Protein ZO-1.
J.Biol.Chem., 286, 2011
3TSW
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BU of 3tsw by Molmil
crystal structure of the PDZ3-SH3-GUK core module of Human ZO-1
分子名称: SULFATE ION, Tight junction protein ZO-1
著者Nomme, J, Lavie, A.
登録日2011-09-13
公開日2011-10-12
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.847 Å)
主引用文献The Src Homology 3 Domain Is Required for Junctional Adhesion Molecule Binding to the Third PDZ Domain of the Scaffolding Protein ZO-1.
J.Biol.Chem., 286, 2011
3TSV
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BU of 3tsv by Molmil
crystal structure of the third PDZ domain of the human ZO-1 MAGUK protein
分子名称: Tight junction protein ZO-1
著者Nomme, J, Lavie, A.
登録日2011-09-13
公開日2011-10-12
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.989 Å)
主引用文献The Src Homology 3 Domain Is Required for Junctional Adhesion Molecule Binding to the Third PDZ Domain of the Scaffolding Protein ZO-1.
J.Biol.Chem., 286, 2011
4KCG
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BU of 4kcg by Molmil
Human dCK C4S-S74E mutant in complex with UDP and the DI-39 inhibitor
分子名称: Deoxycytidine kinase, N-{2-[5-(4-{[(4,6-diaminopyrimidin-2-yl)sulfanyl]methyl}-5-propyl-1,3-thiazol-2-yl)-2-methoxyphenoxy]ethyl}methanesulfonamide, URIDINE-5'-DIPHOSPHATE
著者Nomme, J, Lavie, A.
登録日2013-04-24
公開日2014-03-12
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.09 Å)
主引用文献Co-targeting of convergent nucleotide biosynthetic pathways for leukemia eradication.
J.Exp.Med., 211, 2014
4JLJ
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BU of 4jlj by Molmil
Human dCK C4S-S74E mutant in complex with UDP and the F2.1.1 inhibitor (2-[({2-[3-(2-FLUOROETHOXY)-4-METHOXYPHENYL]-1,3-THIAZOL-4-YL}METHYL)SULFANYL]PYRIMIDINE-4,6-DIAMINE)
分子名称: 2-[({2-[3-(2-fluoroethoxy)-4-methoxyphenyl]-1,3-thiazol-4-yl}methyl)sulfanyl]pyrimidine-4,6-diamine, Deoxycytidine kinase, URIDINE-5'-DIPHOSPHATE
著者Nomme, J, Lavie, A.
登録日2013-03-12
公開日2014-01-22
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural characterization of new deoxycytidine kinase inhibitors rationalizes the affinity-determining moieties of the molecules.
Acta Crystallogr.,Sect.D, 70, 2014
4JLN
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BU of 4jln by Molmil
Human dCK C4S-S74E mutant in complex with UDP and the F2.4.1 inhibitor (2-[({2-[3-(2-FLUOROETHOXY)-4-METHOXYPHENYL]-5-PROPYL-1,3-THIAZOL-4-YL}METHYL)SULFANYL]PYRIMIDINE-4,6-DIAMINE)
分子名称: 2-[({2-[3-(2-fluoroethoxy)-4-methoxyphenyl]-5-propyl-1,3-thiazol-4-yl}methyl)sulfanyl]pyrimidine-4,6-diamine, Deoxycytidine kinase, URIDINE-5'-DIPHOSPHATE
著者Nomme, J, Lavie, A.
登録日2013-03-12
公開日2014-01-22
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Structural characterization of new deoxycytidine kinase inhibitors rationalizes the affinity-determining moieties of the molecules.
Acta Crystallogr.,Sect.D, 70, 2014
4JLM
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BU of 4jlm by Molmil
Human dCK C4S-S74E mutant in complex with UDP and the F2.3.1 inhibitor (2-[({5-ETHYL-2-[3-(2-FLUOROETHOXY)-4-METHOXYPHENYL]-1,3-THIAZOL-4-YL}METHYL)SULFANYL]PYRIMIDINE-4,6-DIAMINE)
分子名称: 2-[({5-ethyl-2-[3-(2-fluoroethoxy)-4-methoxyphenyl]-1,3-thiazol-4-yl}methyl)sulfanyl]pyrimidine-4,6-diamine, Deoxycytidine kinase, URIDINE-5'-DIPHOSPHATE
著者Nomme, J, Lavie, A.
登録日2013-03-12
公開日2014-01-22
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.18 Å)
主引用文献Structural characterization of new deoxycytidine kinase inhibitors rationalizes the affinity-determining moieties of the molecules.
Acta Crystallogr.,Sect.D, 70, 2014
4JLK
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BU of 4jlk by Molmil
Human dCK C4S-S74E mutant in complex with UDP and the F2.2.1 inhibitoR (2-[({2-[3-(2-FLUOROETHOXY)-4-METHOXYPHENYL]-5-METHYL-1,3-THIAZOL-4-YL}METHYL)SULFANYL]PYRIMIDINE-4,6-DIAMINE)
分子名称: 2-[({2-[3-(2-fluoroethoxy)-4-methoxyphenyl]-5-methyl-1,3-thiazol-4-yl}methyl)sulfanyl]pyrimidine-4,6-diamine, Deoxycytidine kinase, URIDINE-5'-DIPHOSPHATE
著者Nomme, J, Lavie, A.
登録日2013-03-12
公開日2013-09-18
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.89 Å)
主引用文献Development of new deoxycytidine kinase inhibitors and noninvasive in vivo evaluation using positron emission tomography.
J.Med.Chem., 56, 2013
4L5B
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BU of 4l5b by Molmil
Human dCK C4S-S74E mutant in complex with UDP and the DI-43 inhibitor
分子名称: 1-[5-(4-{[(4,6-diaminopyrimidin-2-yl)sulfanyl]methyl}-5-propyl-1,3-thiazol-2-yl)-2-methoxyphenoxy]-2-methylpropan-2-ol, Deoxycytidine kinase, URIDINE-5'-DIPHOSPHATE
著者Nomme, J, Lavie, A.
登録日2013-06-10
公開日2013-09-18
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.94 Å)
主引用文献Development of new deoxycytidine kinase inhibitors and noninvasive in vivo evaluation using positron emission tomography.
J.Med.Chem., 56, 2013
4O0D
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BU of 4o0d by Molmil
Crystal structure of the human L-asparaginase protein T168S mutant
分子名称: GLYCINE, Isoaspartyl peptidase/L-asparaginase, SODIUM ION
著者Nomme, J, Lavie, A.
登録日2013-12-13
公開日2014-04-30
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Elucidation of the Specific Function of the Conserved Threonine Triad Responsible for Human l-Asparaginase Autocleavage and Substrate Hydrolysis.
J.Mol.Biol., 426, 2014
4O0E
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BU of 4o0e by Molmil
Crystal structure of the human L-asparaginase protein T186V mutant
分子名称: Isoaspartyl peptidase/L-asparaginase, SODIUM ION
著者Nomme, J, Lavie, A.
登録日2013-12-13
公開日2014-04-30
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.71 Å)
主引用文献Elucidation of the Specific Function of the Conserved Threonine Triad Responsible for Human l-Asparaginase Autocleavage and Substrate Hydrolysis.
J.Mol.Biol., 426, 2014
4OSY
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BU of 4osy by Molmil
STRUCTURE of FULLY-CLEAVED GLYCINE-BOUND HUMAN L-ASPARAGINASE PROTEIN
分子名称: GLYCINE, Isoaspartyl peptidase/L-asparaginase, SODIUM ION
著者Nomme, J, Lavie, A.
登録日2014-02-13
公開日2014-03-05
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.91 Å)
主引用文献Free glycine accelerates the autoproteolytic activation of human asparaginase.
Chem.Biol., 20, 2013
4O0F
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BU of 4o0f by Molmil
Crystal structure of the human L-asparaginase protein T219A mutant
分子名称: GLYCINE, Isoaspartyl peptidase/L-asparaginase, SODIUM ION
著者Nomme, J, Lavie, A.
登録日2013-12-13
公開日2014-04-30
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.92 Å)
主引用文献Elucidation of the Specific Function of the Conserved Threonine Triad Responsible for Human l-Asparaginase Autocleavage and Substrate Hydrolysis.
J.Mol.Biol., 426, 2014
4O0C
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BU of 4o0c by Molmil
High resolution crystal structure of uncleaved human L-asparaginase protein
分子名称: CHLORIDE ION, DIMETHYL SULFOXIDE, Isoaspartyl peptidase/L-asparaginase, ...
著者Nomme, J, Lavie, A.
登録日2013-12-13
公開日2014-04-30
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Elucidation of the Specific Function of the Conserved Threonine Triad Responsible for Human l-Asparaginase Autocleavage and Substrate Hydrolysis.
J.Mol.Biol., 426, 2014
4O0G
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BU of 4o0g by Molmil
Crystal structure of the human L-asparaginase protein T219V mutant
分子名称: Isoaspartyl peptidase/L-asparaginase, SODIUM ION
著者Nomme, J, Lavie, A.
登録日2013-12-13
公開日2014-04-30
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Elucidation of the Specific Function of the Conserved Threonine Triad Responsible for Human l-Asparaginase Autocleavage and Substrate Hydrolysis.
J.Mol.Biol., 426, 2014
4O0H
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BU of 4o0h by Molmil
Crystal structure of human L-asparaginase protein with covalently linked substrate L-asparagine
分子名称: BETA-L-ASPARTIC ACID, Isoaspartyl peptidase/L-asparaginase, SODIUM ION
著者Nomme, J, Lavie, A.
登録日2013-12-13
公開日2014-04-30
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.97 Å)
主引用文献Elucidation of the Specific Function of the Conserved Threonine Triad Responsible for Human l-Asparaginase Autocleavage and Substrate Hydrolysis.
J.Mol.Biol., 426, 2014
4OSX
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BU of 4osx by Molmil
STRUCTURE of UNCLEAVED GLYCINE-BOUND HUMAN L-ASPARAGINASE PROTEIN
分子名称: GLYCINE, Isoaspartyl peptidase/L-asparaginase, SODIUM ION
著者Nomme, J, Lavie, A.
登録日2014-02-13
公開日2014-03-05
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Free Glycine Accelerates the Autoproteolytic Activation of Human Asparaginase.
Chem.Biol., 20, 2013
4OEO
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BU of 4oeo by Molmil
High resolution crystal structure of the unliganded ZO-1 PDZ1 domain
分子名称: ACETATE ION, DODECAETHYLENE GLYCOL, SULFATE ION, ...
著者Nomme, J, Lavie, A.
登録日2014-01-13
公開日2015-01-14
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural Basis of a Key Factor Regulating the Affinity between the Zonula Occludens First PDZ Domain and Claudins.
J.Biol.Chem., 290, 2015
4PVR
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BU of 4pvr by Molmil
Crystal structure of partially-cleaved human l-asparaginase protein in complex with l-aspartate
分子名称: ASPARTIC ACID, Isoaspartyl peptidase/L-asparaginase, SODIUM ION
著者Nomme, J, Lavie, A.
登録日2014-03-18
公開日2014-03-26
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Structures of apo and product-bound human L-asparaginase: insights into the mechanism of autoproteolysis and substrate hydrolysis.
Biochemistry, 51, 2012

 

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