3TSZ

crystal structure of PDZ3-SH3-GUK core module from human ZO-1 in complex with 12mer peptide from human JAM-A cytoplasmic tail

Summary for 3TSZ

• Entry DOI: 10.2210/pdb3tsz/pdb
• Related: 3TSV 3TSW
• Descriptor: Tight junction protein ZO-1, Junctional adhesion molecule A (3 entities in total)
• Functional Keywords: pdz3-sh3-guk, scaffolding, jam, tight junction, cell adhesion
• Biological source: Homo sapiens (human); More
• Cellular location: Cell membrane; Peripheral membrane protein; Cytoplasmic side: Q07157; Cell junction, tight junction: Q9Y624
• Total number of polymer chains: 2
• Total formula weight: 46033.41

Authors

Nomme, J.,Lavie, A. (deposition date: 2011-09-13, release date: 2011-10-12, Last modification date: 2023-09-13)

• Primary citation: Nomme, J.,Fanning, A.S.,Caffrey, M.,Lye, M.F.,Anderson, J.M.,Lavie, A.; The Src Homology 3 Domain Is Required for Junctional Adhesion Molecule Binding to the Third PDZ Domain of the Scaffolding Protein ZO-1.; J.Biol.Chem., 286:43352-43360, 2011; PubMed: 22030391; DOI: 10.1074/jbc.M111.304089

Experimental method

X-RAY DIFFRACTION (2.502 Å)