4Q18

Human dCK C4S-S74E mutant in complex with UDP and the inhibitor 4 [1-[5-(4-{[(2,6-diaminopyrimidin-4-yl)sulfanyl]methyl}-5-propyl-1,3-thiazol-2-yl)-2-methoxyphenoxy]-2-methylpropan-2-ol]

Summary for 4Q18

• Entry DOI: 10.2210/pdb4q18/pdb
• Related: 4Q19 4Q1A 4Q1B 4Q1C 4Q1D 4Q1E 4Q1F
• Descriptor: Deoxycytidine kinase, 1-(5-(4-(((2,6-diaminopyrimidin-4-yl)thio)methyl)-5-propylthiazol-2-yl)-2-methoxyphenoxy)-2-methylpropan-2-ol, URIDINE-5'-DIPHOSPHATE, ... (4 entities in total)
• Functional Keywords: phosphoryl transfer, phosphorylation, deoxycytidine, transferase, inhibitor complex, kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus : P27707
• Total number of polymer chains: 2
• Total formula weight: 68114.08

Authors

Nomme, J.,Lavie, A. (deposition date: 2014-04-03, release date: 2014-11-05, Last modification date: 2023-09-20)

• Primary citation: Nomme, J.,Li, Z.,Gipson, R.M.,Wang, J.,Armijo, A.L.,Le, T.,Poddar, S.,Smith, T.,Santarsiero, B.D.,Nguyen, H.A.,Czernin, J.,Alexandrova, A.N.,Jung, M.E.,Radu, C.G.,Lavie, A.; Structure-guided development of deoxycytidine kinase inhibitors with nanomolar affinity and improved metabolic stability.; J.Med.Chem., 57:9480-9494, 2014; PubMed: 25341194; DOI: 10.1021/jm501124j

Experimental method

X-RAY DIFFRACTION (2 Å)