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PDB: 205 件
2BTJ
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BU of 2btj by Molmil
Fluorescent Protein EosFP - red form
分子名称: Green to red photoconvertible GFP-like protein EosFP
著者Nar, H, Nienhaus, K, Wiedenmann, J, Nienhaus, G.U.
登録日2005-06-01
公開日2005-06-23
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural Basis for Photo-Induced Protein Cleavage and Green-to-Red Conversion of Fluorescent Protein Eosfp.
Proc.Natl.Acad.Sci.USA, 102, 2005
4K8B
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BU of 4k8b by Molmil
Crystal structure of HCV NS3/4A protease complexed with inhibitor
分子名称: N-(tert-butylcarbamoyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-carboxy-2-ethenylcyclopropyl]-4-[(7-methoxy-2-phenylquinolin-4-yl)oxy]-L-prolinamide, NS3 protease, Nonstructural protein, ...
著者Nar, H.
登録日2013-04-18
公開日2014-03-26
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Ligand bioactive conformation plays a critical role in the design of drugs that target the hepatitis C virus NS3 protease.
J.Med.Chem., 57, 2014
8P01
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BU of 8p01 by Molmil
Crystal structure of human STING ectodomain in complex with BI 7446, a potent cyclic dinucleotide STING agonist with broad-spectrum variant activity for the treatment of cancer
分子名称: 3-[(1~{R},3~{R},6~{R},8~{R},9~{R},10~{R},12~{R},15~{R},17~{R},18~{R})-8-(6-aminopurin-9-yl)-9-fluoranyl-18-oxidanyl-3,12-bis(oxidanylidene)-3,12-bis(sulfanyl)-2,4,7,11,13,16-hexaoxa-3$l^{5},12$l^{5}-diphosphatricyclo[13.2.1.0^{6,10}]octadecan-17-yl]-6~{H}-imidazo[4,5-d]pyridazin-7-one, Stimulator of interferon genes protein
著者Nar, H.
登録日2023-05-09
公開日2023-07-26
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (2.094 Å)
主引用文献Discovery of BI 7446: A Potent Cyclic Dinucleotide STING Agonist with Broad-Spectrum Variant Activity for the Treatment of Cancer.
J.Med.Chem., 66, 2023
8Q6N
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BU of 8q6n by Molmil
Xanthin riboswitch in complex with oxypurinol
分子名称: Oxypurinol, Xanthin riboswitch NMT-46 (46-MER)
著者Nar, H.
登録日2023-08-14
公開日2024-08-28
実験手法X-RAY DIFFRACTION (2.63 Å)
主引用文献Artificial oxypurinol-responsive riboswitches for gene expression control in mammalian cells based on bacterial xanthine aptamers
To Be Published
5LLS
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BU of 5lls by Molmil
Porcine dipeptidyl peptidase IV in complex with 8-(3-aminopiperidin-1-yl)-7-[(2-bromophenyl)methyl]-1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 8-[(3~{R})-3-azanylpiperidin-1-yl]-7-[(2-bromophenyl)methyl]-1,3-dimethyl-purine-2,6-dione, ...
著者Nar, H, Blaesse, M.
登録日2016-07-28
公開日2016-09-14
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.41 Å)
主引用文献Comparative Analysis of Binding Kinetics and Thermodynamics of Dipeptidyl Peptidase-4 Inhibitors and Their Relationship to Structure.
J.Med.Chem., 59, 2016
6TL9
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BU of 6tl9 by Molmil
CRYSTAL STRUCTURE OF LECTIN-LIKE OX-LDL RECEPTOR 1 IN COMPLEX WITH BI-0115
分子名称: 9-chloranyl-5-propyl-11~{H}-pyrido[2,3-b][1,4]benzodiazepin-6-one, GLYCEROL, Oxidized low-density lipoprotein receptor 1
著者Nar, H, Fiegen, D, Schnapp, G.
登録日2019-12-02
公開日2020-07-22
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2.734 Å)
主引用文献A small-molecule inhibitor of lectin-like oxidized LDL receptor-1 acts by stabilizing an inactive receptor tetramer state
Commun Chem, 2020
6TLA
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BU of 6tla by Molmil
CRYSTAL STRUCTURE OF LECTIN-LIKE OX-LDL RECEPTOR 1 (C 1 2 1)
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Oxidized low-density lipoprotein receptor 1
著者Nar, H, Fiegen, D, Schnapp, G.
登録日2019-12-02
公開日2020-07-22
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.16 Å)
主引用文献A small-molecule inhibitor of lectin-like oxidized LDL receptor-1 acts by stabilizing an inactive receptor tetramer state
Commun Chem, 2020
6TL7
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CRYSTAL STRUCTURE OF LECTIN-LIKE OX-LDL RECEPTOR 1 (P212121)
分子名称: NICKEL (II) ION, Oxidized low-density lipoprotein receptor 1
著者Nar, H, Fiegen, D, Schnapp, G.
登録日2019-12-02
公開日2020-07-22
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.11 Å)
主引用文献A small-molecule inhibitor of lectin-like oxidized LDL receptor-1 acts by stabilizing an inactive receptor tetramer state
Commun Chem, 2020
5AZU
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BU of 5azu by Molmil
CRYSTAL STRUCTURE ANALYSIS OF OXIDIZED PSEUDOMONAS AERUGINOSA AZURIN AT PH 5.5 AND PH 9.0. A PH-INDUCED CONFORMATIONAL TRANSITION INVOLVES A PEPTIDE BOND FLIP
分子名称: AZURIN, COPPER (II) ION, NITRATE ION
著者Nar, H, Messerschmidt, A, Huber, R.
登録日1993-06-23
公開日1994-01-31
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal structure analysis of oxidized Pseudomonas aeruginosa azurin at pH 5.5 and pH 9.0. A pH-induced conformational transition involves a peptide bond flip.
J.Mol.Biol., 221, 1991
6Y0F
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BU of 6y0f by Molmil
Structure of human FAPalpha in complex with linagliptin
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-methyl-1-[(4-methylquinazolin-2-yl)methyl]-3,7-dihydro-1H-purine-2,6-d ione, ...
著者Nar, H, Schnapp, G, Schreiner, P.
登録日2020-02-07
公開日2021-02-17
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2.924 Å)
主引用文献Structure of human FAPalpha in complex with linagliptin
To Be Published
5F2P
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Crystal structure of the BRD9 bromodomain in complex with compound 3.
分子名称: 2-(dimethylamino)-6-methyl-pyrido[4,3-d]pyrimidin-5-one, BRD9
著者Nar, H, Fiegen, D, Zoephel, A, Bader, G.
登録日2015-12-02
公開日2016-03-09
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structure-Based Design of an in Vivo Active Selective BRD9 Inhibitor.
J.Med.Chem., 59, 2016
3NJW
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BU of 3njw by Molmil
First High Resolution Crystal Structure of a Lasso Peptide
分子名称: Bicyclic peptide BI-32169
著者Nar, H, Schmid, A, Puder, C, Potterat, O.
登録日2010-06-18
公開日2010-09-01
最終更新日2011-08-10
実験手法X-RAY DIFFRACTION (0.86 Å)
主引用文献High-resolution crystal structure of a lasso Peptide.
Chemmedchem, 5, 2010
3E5V
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BU of 3e5v by Molmil
Crystal Structure Analysis of eqFP611 Double Mutant T122R, N143S
分子名称: Red fluorescent protein eqFP611
著者Nar, H, Nienhaus, K, Nienhaus, U, Wiedenmann, J.
登録日2008-08-14
公開日2008-09-23
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Trans-cis isomerization is responsible for the red-shifted fluorescence in variants of the red fluorescent protein eqFP611.
J.Am.Chem.Soc., 130, 2008
3E5T
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BU of 3e5t by Molmil
Crystal Structure Analysis of FP611
分子名称: Red fluorescent protein eqFP611
著者Nar, H, Nienhaus, K, Nienhaus, U, Wiedenmann, J.
登録日2008-08-14
公開日2008-09-23
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.1 Å)
主引用文献Trans-cis isomerization is responsible for the red-shifted fluorescence in variants of the red fluorescent protein eqFP611.
J.Am.Chem.Soc., 130, 2008
4AZU
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BU of 4azu by Molmil
CRYSTAL STRUCTURE ANALYSIS OF OXIDIZED PSEUDOMONAS AERUGINOSA AZURIN AT PH 5.5 AND PH 9.0. A PH-INDUCED CONFORMATIONAL TRANSITION INVOLVES A PEPTIDE BOND FLIP
分子名称: AZURIN, COPPER (II) ION, NITRATE ION
著者Nar, H, Messerschmidt, A, Huber, R.
登録日1993-06-23
公開日1994-01-31
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal structure analysis of oxidized Pseudomonas aeruginosa azurin at pH 5.5 and pH 9.0. A pH-induced conformational transition involves a peptide bond flip.
J.Mol.Biol., 221, 1991
2RGU
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BU of 2rgu by Molmil
Crystal structure of complex of human DPP4 and inhibitor
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-methyl-1-[(4-methylquinazolin-2-yl)methyl]-3,7-dihydro-1H-purine-2,6-d ione, Dipeptidyl peptidase 4
著者Nar, H, Himmelsbach, F, Eckhardt, M.
登録日2007-10-05
公開日2007-11-06
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献8-(3-(R)-Aminopiperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydropurine-2,6-dione (BI 1356), a Highly Potent, Selective, Long-Acting, and Orally Bioavailable DPP-4 Inhibitor for the Treatment of Type 2 Diabetes.
J.Med.Chem., 50, 2007
1JIZ
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BU of 1jiz by Molmil
Crystal Structure Analysis of human Macrophage Elastase MMP-12
分子名称: CALCIUM ION, N-HYDROXY-2(R)-[[(4-METHOXYPHENYL)SULFONYL](3-PICOLYL)AMINO]-3-METHYLBUTANAMIDE HYDROCHLORIDE, ZINC ION, ...
著者Nar, H, Werle, K, Bauer, M.M.T, Dollinger, H, Jung, B.
登録日2001-07-03
公開日2002-07-03
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Crystal structure of human macrophage elastase (MMP-12) in complex with a hydroxamic acid inhibitor.
J.Mol.Biol., 312, 2001
1KTS
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BU of 1kts by Molmil
Thrombin Inhibitor Complex
分子名称: 3-({2-[(4-CARBAMIMIDOYL-PHENYLAMINO)-METHYL]-3-METHYL-3H-BENZOIMIDAZOLE-5-CARBONYL}-PYRIDIN-2-YL-AMINO)-PROPIONIC ACID ETHYL ESTER, hirudin IIB, thrombin
著者Nar, H.
登録日2002-01-17
公開日2002-02-06
最終更新日2013-03-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structure-based design of novel potent nonpeptide thrombin inhibitors.
J.Med.Chem., 45, 2002
1KTT
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BU of 1ktt by Molmil
Thrombin inhibitor complex
分子名称: 4-(5-BENZENESULFONYLAMINO-1-METHYL-1H-BENZOIMIDAZOL-2-YLMETHYL)-BENZAMIDINE, hirudin IIB, thrombin
著者Nar, H.
登録日2002-01-17
公開日2002-02-06
最終更新日2013-03-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structure-based design of novel potent nonpeptide thrombin inhibitors.
J.Med.Chem., 45, 2002
1ZUX
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BU of 1zux by Molmil
EosFP Fluorescent Protein- Green Form
分子名称: green to red photoconvertible GPF-like protein EosFP
著者Nar, H, Nienhaus, K, Wiedenmann, J, Nienhaus, G.U.
登録日2005-06-01
公開日2005-06-28
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Structural basis for photo-induced protein cleavage and green-to-red conversion of fluorescent protein EosFP.
Proc.Natl.Acad.Sci.Usa, 102, 2005
2AZU
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BU of 2azu by Molmil
X-RAY CRYSTAL STRUCTURE OF THE TWO SITE-SPECIFIC MUTANTS HIS35*GLN AND HIS35*LEU OF AZURIN FROM PSEUDOMONAS AERUGINOSA
分子名称: AZURIN, COPPER (II) ION, NITRATE ION
著者Nar, H, Messerschmidt, A, Huber, R.
登録日1991-01-11
公開日1993-07-15
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献X-ray crystal structure of the two site-specific mutants His35Gln and His35Leu of azurin from Pseudomonas aeruginosa.
J.Mol.Biol., 218, 1991
1DB2
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BU of 1db2 by Molmil
CRYSTAL STRUCTURE OF NATIVE PLASMINOGEN ACTIVATOR INHIBITOR-1
分子名称: PLASMINOGEN ACTIVATOR INHIBITOR-1
著者Nar, H, Bauer, M, Stassen, J.M, Lang, D, Gils, A, Declerck, P.
登録日1999-11-02
公開日1999-11-10
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Plasminogen activator inhibitor 1. Structure of the native serpin, comparison to its other conformers and implications for serpin inactivation.
J.Mol.Biol., 297, 2000
1E67
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Zn-Azurin from Pseudomonas aeruginosa
分子名称: AZURIN, NITRATE ION, ZINC ION
著者Nar, H, Messerschmidt, A.
登録日2000-08-09
公開日2000-08-16
最終更新日2017-07-12
実験手法X-RAY DIFFRACTION (2.14 Å)
主引用文献Characterization and Crystal Structure of Zinc Azurin, a by-Product of Heterologous Expression in Escherichia Coli of Pseudomonas Aeruginosa Copper Azurin
Eur.J.Biochem., 205, 1992
1E5Y
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Azurin from Pseudomonas aeruginosa, reduced form, pH 5.5
分子名称: AZURIN, COPPER (II) ION, NITRATE ION
著者Nar, H, Messerschmidt, A.
登録日2000-08-04
公開日2000-08-19
最終更新日2017-07-12
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Rontgenkristallographische Strukturaufklarung Von Azurin Aus Pseudomonas Aeruginosa
Ph.D. Thesis, 1992
1E65
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Azurin from Pseudomonas aeruginosa, apo form
分子名称: AZURIN
著者Nar, H, Messerschmidt, A.
登録日2000-08-08
公開日2000-08-16
最終更新日2017-07-12
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Crystal Structure of Pseudomonas Aeruginosa Apo-Azurin at 1.85 A Resolution.
FEBS Lett., 306, 1992

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