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PDB: 75 results
6R37
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BU of 6r37 by Molmil
T. brucei FPPS in complex with 2-(5-chlorobenzo[b]thiophen-3-yl)acetic acid
Descriptor: (5-chloro-1-benzothiophen-3-yl)acetic acid, DIMETHYL SULFOXIDE, Farnesyl pyrophosphate synthase
Authors:Muenzker, L, Petrick, J.K, Schleberger, C, Jahnke, W.
Deposit date:2019-03-19
Release date:2020-04-08
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Targeting Trypanosoma brucei FPPS by Fragment-based drug discovery
Thesis, 2019
6R38
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BU of 6r38 by Molmil
T. brucei FPPS in complex with 2-(2,5-dichlorobenzo[b]thiophen-3-yl)acetic acid
Descriptor: 2-[2,5-bis(chloranyl)-1-benzothiophen-3-yl]ethanoic acid, DIMETHYL SULFOXIDE, Farnesyl pyrophosphate synthase
Authors:Muenzker, L, Petrick, J.K, Schleberger, C, Jahnke, W.
Deposit date:2019-03-19
Release date:2020-04-08
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:Targeting Trypanosoma brucei FPPS by Fragment-based drug discovery
Thesis, 2019
6SII
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BU of 6sii by Molmil
T. brucei FPPS in complex with 1-((1H-indol-3-yl)methyl)-N-(3-chlorobenzyl)piperidin-4-amine
Descriptor: Farnesyl pyrophosphate synthase, GLYCEROL, ~{N}-[(3-chlorophenyl)methyl]-1-(1~{H}-indol-3-ylmethyl)piperidin-4-amine
Authors:Muenzker, L, Petrick, J.K, Schleberger, C, Jahnke, W.
Deposit date:2019-08-09
Release date:2020-08-26
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:T. brucei FPPS
To Be Published
8R6B
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BU of 8r6b by Molmil
DTX1 WWE domain in complex with ADP bound to WWE2
Descriptor: ADENOSINE-5'-DIPHOSPHATE, E3 ubiquitin-protein ligase DTX1
Authors:Muenzker, L, Zak, K.M, Boettcher, J.
Deposit date:2023-11-21
Release date:2024-07-31
Last modified:2024-08-07
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A ligand discovery toolbox for the WWE domain family of human E3 ligases.
Commun Biol, 7, 2024
6R36
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BU of 6r36 by Molmil
T. brucei farnesyl pyrophosphate synthase (FPPS)
Descriptor: DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, Farnesyl pyrophosphate synthase
Authors:Muenzker, L, Petrick, J.K, Schleberger, C, Jahnke, W.
Deposit date:2019-03-19
Release date:2020-04-08
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:Fragment-Based Discovery of Non-bisphosphonate Binders of Trypanosoma brucei Farnesyl Pyrophosphate Synthase.
Chembiochem, 21, 2020
8RD7
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BU of 8rd7 by Molmil
HUWE1 WWE domain in complex with ADP-ribose
Descriptor: ACETATE ION, CHLORIDE ION, E3 ubiquitin-protein ligase HUWE1, ...
Authors:Muenzker, L, Zak, K.M, Boettcher, J.
Deposit date:2023-12-07
Release date:2024-07-31
Last modified:2024-08-07
Method:X-RAY DIFFRACTION (1.31 Å)
Cite:A ligand discovery toolbox for the WWE domain family of human E3 ligases.
Commun Biol, 7, 2024
8R7O
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BU of 8r7o by Molmil
HUWE1 WWE domain in complex with 2'F-ATP
Descriptor: CHLORIDE ION, E3 ubiquitin-protein ligase HUWE1, SODIUM ION, ...
Authors:Muenzker, L, Boettcher, J.
Deposit date:2023-11-27
Release date:2024-07-31
Last modified:2024-08-07
Method:X-RAY DIFFRACTION (1.36 Å)
Cite:A ligand discovery toolbox for the WWE domain family of human E3 ligases.
Commun Biol, 7, 2024
8RD1
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BU of 8rd1 by Molmil
HUWE1 WWE domain in complex with compound 4
Descriptor: 2-(2-hydroxy-2-oxoethyl)-1,3-bis(oxidanylidene)isoindole-5-carboxylic acid, CHLORIDE ION, E3 ubiquitin-protein ligase HUWE1
Authors:Muenzker, L, Zak, K.M, Boettcher, J.
Deposit date:2023-12-07
Release date:2024-07-31
Last modified:2024-08-07
Method:X-RAY DIFFRACTION (1.896 Å)
Cite:A ligand discovery toolbox for the WWE domain family of human E3 ligases.
Commun Biol, 7, 2024
8RD0
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BU of 8rd0 by Molmil
HUWE1 WWE domain in complex with compound 3
Descriptor: (1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)acetic acid, CHLORIDE ION, E3 ubiquitin-protein ligase HUWE1
Authors:Muenzker, L, Boettcher, J.
Deposit date:2023-12-07
Release date:2024-07-31
Last modified:2024-08-07
Method:X-RAY DIFFRACTION (1.765 Å)
Cite:A ligand discovery toolbox for the WWE domain family of human E3 ligases.
Commun Biol, 7, 2024
8R5N
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BU of 8r5n by Molmil
DTX1 WWE domain in complex with ATP
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, E3 ubiquitin-protein ligase DTX1
Authors:Muenzker, L, Zak, K.M, Boettcher, J.
Deposit date:2023-11-17
Release date:2024-07-31
Last modified:2024-08-07
Method:X-RAY DIFFRACTION (1.812 Å)
Cite:A ligand discovery toolbox for the WWE domain family of human E3 ligases.
Commun Biol, 7, 2024
8R6A
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BU of 8r6a by Molmil
DTX1 WWE domain in complex with ADP bound to WWE1
Descriptor: ADENOSINE-5'-DIPHOSPHATE, E3 ubiquitin-protein ligase DTX1
Authors:Muenzker, L, Zak, K.M, Boettcher, J.
Deposit date:2023-11-21
Release date:2024-07-31
Last modified:2024-08-07
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A ligand discovery toolbox for the WWE domain family of human E3 ligases.
Commun Biol, 7, 2024
6R39
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BU of 6r39 by Molmil
T. brucei FPPS in complex with 1-(carboxymethyl)-1H-benzo[g]indole-2-carboxylic acid
Descriptor: 1-(carboxymethyl)-1H-benzo[g]indole-2-carboxylic acid, Farnesyl pyrophosphate synthase
Authors:Muenzker, L, Petrick, J.K, Schleberger, C, Jahnke, W.
Deposit date:2019-03-19
Release date:2020-04-08
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Targeting farnesyl pyrophosphate synthase of Trypanosoma cruzi by fragment-based lead discovery
Thesis, 2019
5QT8
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BU of 5qt8 by Molmil
T. brucei FPPS in complex with CAS 34105-16-3
Descriptor: (2R)-1-[(4-chlorophenyl)(methyl)amino]-3-(1H-imidazol-1-yl)propan-2-ol, DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, ...
Authors:Muenzker, L, Petrick, J.K, Schleberger, C, Jahnke, W.
Deposit date:2019-08-07
Release date:2020-10-07
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:T. brucei FPPS in complex with CAS 34105-16-3
To Be Published
5QTC
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BU of 5qtc by Molmil
Unliganded T. brucei FPPS
Descriptor: DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, Farnesyl pyrophosphate synthase
Authors:Muenzker, L, Petrick, J.P, Schleberger, C, Jahnke, W.
Deposit date:2019-08-07
Release date:2020-10-07
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.645 Å)
Cite:Unliganded T. brucei FPPS
To Be Published
5QTD
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BU of 5qtd by Molmil
Unliganded T. brucei FPPS
Descriptor: Farnesyl pyrophosphate synthase, GLYCEROL, PHOSPHATE ION, ...
Authors:Muenzker, L, Petrick, J.K, Schleberger, C, Cornaciu, I, Marquez, J.A, Jahnke, W.
Deposit date:2019-08-09
Release date:2020-10-07
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.642 Å)
Cite:Unliganded T. brucei FPPS
To Be Published
5QT5
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BU of 5qt5 by Molmil
T. brucei FPPS in complex with CID 89021
Descriptor: 6-ethylpyridin-2-amine, DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, ...
Authors:Muenzker, L, Petrick, J.K, Schleberger, C, Jahnke, W.
Deposit date:2019-08-07
Release date:2020-10-07
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.143 Å)
Cite:T. brucei FPPS in complex with CID 89021
To Be Published
5QTE
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BU of 5qte by Molmil
T. brucei FPPS in complex with CID 4563894
Descriptor: (4S)-3-(4-chlorobenzene-1-carbonyl)-1,3-thiazolidine-4-carboxylic acid, Farnesyl pyrophosphate synthase, GLYCEROL, ...
Authors:Muenzker, L, Petrick, J.K, Schleberger, C, Cornaciu, I, Marquez, J.A, Jahnke, W.
Deposit date:2019-08-09
Release date:2020-10-07
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.072 Å)
Cite:T. brucei FPPS in complex with CID 4563894
To Be Published
5QTK
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BU of 5qtk by Molmil
T. brucei FPPS in complex with CID 69539
Descriptor: Farnesyl pyrophosphate synthase, N,N-diethyl-4-methylbenzene-1-sulfonamide, PHOSPHATE ION, ...
Authors:Muenzker, L, Petrick, J.K, Schleberger, C, Cornaciu, I, Marquez, J.A, Jahnke, W.
Deposit date:2019-08-09
Release date:2020-10-07
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.857 Å)
Cite:T. brucei FPPS in complex with CID 69539
To Be Published
5QT4
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BU of 5qt4 by Molmil
T. brucei FPPS in complex with CID 3599333
Descriptor: 1-[3-(4-chlorophenoxy)propyl]-1H-imidazole, DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, ...
Authors:Muenzker, L, Petrick, J.K, Schleberger, C, Jahnke, W.
Deposit date:2019-08-07
Release date:2020-10-07
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.324 Å)
Cite:T. brucei FPPS in complex with CID 3599333
To Be Published
5QT6
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BU of 5qt6 by Molmil
T. brucei FPPS in complex with CID 112445
Descriptor: 6-methyl-~{N}-(phenylmethyl)pyridin-2-amine, DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, ...
Authors:Muenzker, L, Petrick, J.K, Schleberger, C, Jahnke, W.
Deposit date:2019-08-07
Release date:2020-10-07
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.189 Å)
Cite:T. brucei FPPS in complex with CID 112445
To Be Published
5QT7
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BU of 5qt7 by Molmil
T. brucei FPPS in complex with CID 66669982
Descriptor: DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, Farnesyl pyrophosphate synthase, ...
Authors:Muenzker, L, Petrick, J.K, Schleberger, C, Jahnke, W.
Deposit date:2019-08-07
Release date:2020-10-07
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.292 Å)
Cite:T. brucei FPPS in complex with CID 66669982
To Be Published
5QTG
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BU of 5qtg by Molmil
T. brucei FPPS in complex with CID 126782062
Descriptor: 2-fluoro-N,3-dimethylbenzene-1-sulfonamide, Farnesyl pyrophosphate synthase, GLYCEROL, ...
Authors:Muenzker, L, Petrick, J.K, Schleberger, C, Cornaciu, I, Marquez, J.A, Jahnke, W.
Deposit date:2019-08-09
Release date:2020-10-07
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.093 Å)
Cite:T. brucei FPPS in complex with CID 126782062
To Be Published
5QTF
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BU of 5qtf by Molmil
T. brucei FPPS in complex with CID 144539
Descriptor: 1-(3-chloro-4-fluorophenyl)methanamine, Farnesyl pyrophosphate synthase, GLYCEROL, ...
Authors:Muenzker, L, Petrick, J.K, Schleberger, C, Cornaciu, I, Marquez, J.A, Jahnke, W.
Deposit date:2019-08-09
Release date:2020-10-07
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.783 Å)
Cite:T. brucei FPPS in complex with CID 144539
To Be Published
5QTH
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BU of 5qth by Molmil
T. brucei FPPS in complex with CID 2799882
Descriptor: Farnesyl pyrophosphate synthase, GLYCEROL, N,N-dimethyl-2-(methylsulfanyl)pyridine-3-carboxamide, ...
Authors:Muenzker, L, Petrick, J.K, Schleberger, C, Cornaciu, I, Marquez, J.A, Jahnke, W.
Deposit date:2019-08-09
Release date:2020-10-07
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.887 Å)
Cite:T. brucei FPPS in complex with CID 2799882
To Be Published
5QT9
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BU of 5qt9 by Molmil
T. brucei FPPS in complex with CID 23155989
Descriptor: (1S)-3-chloro-1-(4-methylpiperazin-1-yl)-1,4-dihydroisoquinoline, DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, ...
Authors:Muenzker, L, Petrick, J.K, Schleberger, C, Jahnke, W.
Deposit date:2019-08-07
Release date:2020-10-07
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.199 Å)
Cite:T. brucei FPPS in complex with CID 23155989
To Be Published

 

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PDB entries from 2024-09-04

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