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PDB: 43 件
5HI9
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Structure of the full-length TRPV2 channel by cryo-electron microscopy
分子名称: Transient Receptor Potential Cation Channel Subfamily V Member 2
著者Huynh, K.W, Cohen, M.R, Jiansen, J, Samanta, A, Lodowski, D.T, Zhou, Z.H, Moiseenkova-Bell, V.Y.
登録日2016-01-11
公開日2016-03-30
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (4.4 Å)
主引用文献Structure of the full-length TRPV2 channel by cryo-EM.
Nat Commun, 7, 2016
7N0N
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BU of 7n0n by Molmil
Activated state of 2-APB-bound wildtype rat TRPV2 in nanodiscs
分子名称: Transient receptor potential cation channel subfamily V member 2
著者Pumroy, R.A, Protopopova, A.D, Gallo, P.N, Moiseenkova-Bell, V.Y.
登録日2021-05-25
公開日2022-05-04
最終更新日2024-05-29
実験手法ELECTRON MICROSCOPY (4.15 Å)
主引用文献Structural insights into TRPV2 activation by small molecules.
Nat Commun, 13, 2022
6WKN
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BU of 6wkn by Molmil
PL-bound rat TRPV2 in nanodiscs
分子名称: Transient receptor potential cation channel subfamily V member 2, piperlongumine
著者Pumroy, R.P, Moiseenkova-Bell, V.Y.
登録日2020-04-16
公開日2021-04-21
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (3.46 Å)
主引用文献Allosteric Antagonist Modulation of TRPV2 by Piperlongumine Impairs Glioblastoma Progression.
Acs Cent.Sci., 7, 2021
6PBF
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BU of 6pbf by Molmil
ZINC9155420-bound TRPV5 in nanodiscs
分子名称: (1S)-1-(4-oxo-5-phenyl-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl)ethyl [(2S)-3-oxo-3,4-dihydro-2H-1,4-benzothiazin-2-yl]acetate, Transient receptor potential cation channel subfamily V member 5
著者Hughes, T.E.T, Rosario, J.S.D, Kapoor, A, Yazici, A.T, Fluck, E.C, Filizola, M, Rohacs, T, Moiseenkova-Bell, V.Y.
登録日2019-06-13
公開日2019-11-06
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (4.2 Å)
主引用文献Structure-based characterization of novel TRPV5 inhibitors.
Elife, 8, 2019
6PBE
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BU of 6pbe by Molmil
ZINC17988990-bound TRPV5 in nanodiscs
分子名称: (4-oxo-5-phenyl-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl)methyl 3-(3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)propanoate, Transient receptor potential cation channel subfamily V member 5
著者Hughes, T.E.T, Rosario, J.S.D, Kapoor, A, Yazici, A.T, Fluck, E.C, Filizola, M, Rohacs, T, Moiseenkova-Bell, V.Y.
登録日2019-06-13
公開日2019-11-06
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (3.78 Å)
主引用文献Structure-based characterization of novel TRPV5 inhibitors.
Elife, 8, 2019
7T38
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BU of 7t38 by Molmil
Inactivated state of 2-APB and CBD-bound wildtype rat TRPV2 in nanodiscs
分子名称: Transient receptor potential cation channel subfamily V member 2
著者Pumroy, R.A, Protopopova, A.D, Gallo, P.N, Moiseenkova-Bell, V.Y.
登録日2021-12-07
公開日2022-05-04
最終更新日2024-02-28
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献Structural insights into TRPV2 activation by small molecules.
Nat Commun, 13, 2022
7T37
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Activated state of 2-APB and CBD-bound wildtype rat TRPV2 in nanodiscs
分子名称: 2-aminoethyl diphenylborinate, Transient receptor potential cation channel subfamily V member 2, cannabidiol
著者Pumroy, R.A, Protopopova, A.D, Gallo, P.N, Moiseenkova-Bell, V.Y.
登録日2021-12-07
公開日2022-05-04
最終更新日2024-02-28
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献Structural insights into TRPV2 activation by small molecules.
Nat Commun, 13, 2022
7RK8
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Cryo-EM Structure of Adeno-Associated Virus Serotype 9 with Engineered Peptide Domain PHP.B (AAV9-PHP.B)
分子名称: Capsid protein VP1
著者Fluck, E.C, Pumroy, R.A, Moiseenkova-Bell, V.Y.
登録日2021-07-22
公開日2021-08-04
最終更新日2024-06-05
実験手法ELECTRON MICROSCOPY (2.27 Å)
主引用文献Context-Specific Function of the Engineered Peptide Domain of PHP.B.
J.Virol., 95, 2021
7RK9
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Cryo-EM Structure of Adeno-Associated Virus Serotype 1 with Engineered Peptide Domain PHP.B (AAV1-PHP.B)
分子名称: Capsid protein
著者Fluck, E.C, Pumroy, R.A, Moiseenkova-Bell, V.Y.
登録日2021-07-22
公開日2021-08-04
最終更新日2024-06-05
実験手法ELECTRON MICROSCOPY (2.32 Å)
主引用文献Context-Specific Function of the Engineered Peptide Domain of PHP.B.
J.Virol., 95, 2021
8TF3
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BU of 8tf3 by Molmil
Wildtype rabbit TRPV5 into nanodiscs in complex with econazole
分子名称: 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-[(2S)-2-[(4-CHLOROBENZYL)OXY]-2-(2,4-DICHLOROPHENYL)ETHYL]-1H-IMIDAZOLE, ERGOSTEROL, ...
著者De Jesus-Perez, J.J, Fluck, E.C, Moiseenkova-Bell, V.Y.
登録日2023-07-07
公開日2024-01-10
最終更新日2024-02-14
実験手法ELECTRON MICROSCOPY (2.94 Å)
主引用文献Structural mechanism of TRPV5 inhibition by econazole.
Structure, 32, 2024
8TF4
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Wildtype rabbit TRPV5 into nanodiscs in the presence of PI(4,5)P2 and econazole
分子名称: 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-[(2S)-2-[(4-CHLOROBENZYL)OXY]-2-(2,4-DICHLOROPHENYL)ETHYL]-1H-IMIDAZOLE, ERGOSTEROL, ...
著者De Jesus-Perez, J.J, Fluck, E.C, Moiseenkova-Bell, V.Y.
登録日2023-07-07
公開日2024-01-10
最終更新日2024-02-14
実験手法ELECTRON MICROSCOPY (2.86 Å)
主引用文献Structural mechanism of TRPV5 inhibition by econazole.
Structure, 32, 2024
7N0M
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Inactivated state of 2-APB-bound wildtype rat TRPV2 in nanodiscs
分子名称: 2-aminoethyl diphenylborinate, Transient receptor potential cation channel subfamily V member 2
著者Pumroy, R.A, Protopopova, A.D, Gallo, P.N, Moiseenkova-Bell, V.Y.
登録日2021-05-25
公開日2022-05-04
最終更新日2024-05-29
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Structural insights into TRPV2 activation by small molecules.
Nat Commun, 13, 2022
8EKR
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BU of 8ekr by Molmil
Apo rat TRPV2 in nanodiscs, state 3
分子名称: 1,2-DIDECANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, Transient receptor potential cation channel subfamily V member 2
著者Pumroy, R.A, Moiseenkova-Bell, V.Y.
登録日2022-09-21
公開日2023-09-27
最終更新日2024-06-19
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Functional and structural insights into activation of TRPV2 by weak acids.
Embo J., 43, 2024
8EKS
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BU of 8eks by Molmil
rat TRPV2 in nanodiscs in the presence of weak acid at pH 5
分子名称: 1,2-DIDECANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, Transient receptor potential cation channel subfamily V member 2
著者Pumroy, R.A, Moiseenkova-Bell, V.Y.
登録日2022-09-21
公開日2023-09-27
最終更新日2024-06-19
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Functional and structural insights into activation of TRPV2 by weak acids.
Embo J., 43, 2024
8EKP
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BU of 8ekp by Molmil
Apo rat TRPV2 in nanodiscs, state 1
分子名称: 1,2-DIDECANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, Transient receptor potential cation channel subfamily V member 2
著者Pumroy, R.A, Moiseenkova-Bell, V.Y.
登録日2022-09-21
公開日2023-09-27
最終更新日2024-06-19
実験手法ELECTRON MICROSCOPY (2.75 Å)
主引用文献Functional and structural insights into activation of TRPV2 by weak acids.
Embo J., 43, 2024
8EKQ
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BU of 8ekq by Molmil
Apo rat TRPV2 in nanodiscs, state 2
分子名称: 1,2-DIDECANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, Transient receptor potential cation channel subfamily V member 2
著者Pumroy, R.A, Moiseenkova-Bell, V.Y.
登録日2022-09-21
公開日2023-09-27
最終更新日2024-06-19
実験手法ELECTRON MICROSCOPY (2.6 Å)
主引用文献Functional and structural insights into activation of TRPV2 by weak acids.
Embo J., 43, 2024
8TF2
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BU of 8tf2 by Molmil
Wildtype rabbit TRPV5 into nanodiscs in Apo state
分子名称: 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ERGOSTEROL, Transient receptor potential cation channel subfamily V member 5
著者De Jesus-Perez, J.J, Fluck, E.C, Moiseenkova-Bell, V.Y.
登録日2023-07-07
公開日2024-01-10
最終更新日2024-02-14
実験手法ELECTRON MICROSCOPY (2.57 Å)
主引用文献Structural mechanism of TRPV5 inhibition by econazole.
Structure, 32, 2024
6B5V
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BU of 6b5v by Molmil
Structure of TRPV5 in complex with econazole
分子名称: 1-[(2R)-2-[(4-chlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole, CALCIUM ION, Transient receptor potential cation channel subfamily V member 5
著者Hughes, T.E.T, Lodowski, D.T, Huynh, K.W, Yazici, A, del Rosario, J, Kapoor, A, Basak, S, Samanta, A, Chakrapani, S, Zhou, Z.H, Filizola, M, Rohacs, T, Han, S, Moiseenkova-Bell, V.Y.
登録日2017-09-29
公開日2017-12-27
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (4.8 Å)
主引用文献Structural basis of TRPV5 channel inhibition by econazole revealed by cryo-EM.
Nat. Struct. Mol. Biol., 25, 2018
7T6M
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BU of 7t6m by Molmil
Cryo-EM structure of TRPV5 in nanodiscs with PI(4,5)P2 at pH6 state 1
分子名称: Transient receptor potential cation channel subfamily V member 5, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate
著者Fluck, E.C, Yazici, A.T, Rohacs, T, Moiseenkova-Bell, V.Y.
登録日2021-12-14
公開日2022-05-04
最終更新日2024-02-28
実験手法ELECTRON MICROSCOPY (2.8 Å)
主引用文献Structural basis of TRPV5 regulation by physiological and pathophysiological modulators.
Cell Rep, 39, 2022
7T6J
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BU of 7t6j by Molmil
Cryo-EM structure of TRPV5 at pH8 in nanodiscs
分子名称: Transient receptor potential cation channel subfamily V member 5
著者Fluck, E.C, Yazici, A.T, Rohacs, T, Moiseenkova-Bell, V.Y.
登録日2021-12-14
公開日2022-05-04
最終更新日2024-02-28
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Structural basis of TRPV5 regulation by physiological and pathophysiological modulators.
Cell Rep, 39, 2022
7T6K
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BU of 7t6k by Molmil
Cryo-EM structure of TRPV5 at pH6 in nanodiscs
分子名称: Transient receptor potential cation channel subfamily V member 5
著者Fluck, E.C, Yazici, A.T, Rohacs, T, Moiseenkova-Bell, V.Y.
登録日2021-12-14
公開日2022-05-04
最終更新日2024-02-28
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Structural basis of TRPV5 regulation by physiological and pathophysiological modulators.
Cell Rep, 39, 2022
7T6Q
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BU of 7t6q by Molmil
Cryo-EM structure of TRPV5 T709D with PI(4,5)P2 in nanodiscs
分子名称: Transient receptor potential cation channel subfamily V member 5, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate
著者Fluck, E.C, Yazici, A.T, Rohacs, T, Moiseenkova-Bell, V.Y.
登録日2021-12-14
公開日2022-05-04
最終更新日2024-02-28
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Structural basis of TRPV5 regulation by physiological and pathophysiological modulators.
Cell Rep, 39, 2022
7T6R
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BU of 7t6r by Molmil
Cryo-EM structure of TRPV5 T709D in nanodiscs in the presence of Calmodulin
分子名称: Transient receptor potential cation channel subfamily V member 5
著者Fluck, E.C, Yazici, A.T, Rohacs, T, Moiseenkova-Bell, V.Y.
登録日2021-12-14
公開日2022-05-04
最終更新日2024-02-28
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Structural basis of TRPV5 regulation by physiological and pathophysiological modulators.
Cell Rep, 39, 2022
7T6P
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BU of 7t6p by Molmil
Cryo-EM structure of TRPV5 T709D in nanodiscs
分子名称: Transient receptor potential cation channel subfamily V member 5
著者Fluck, E.C, Yazici, A.T, Rohacs, T, Moiseenkova-Bell, V.Y.
登録日2021-12-14
公開日2022-05-04
最終更新日2024-02-28
実験手法ELECTRON MICROSCOPY (2.8 Å)
主引用文献Structural basis of TRPV5 regulation by physiological and pathophysiological modulators.
Cell Rep, 39, 2022
7T6L
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BU of 7t6l by Molmil
Cryo-EM structure of TRPV5 at pH5 in nanodiscs
分子名称: Transient receptor potential cation channel subfamily V member 5
著者Fluck, E.C, Yazici, A.T, Rohacs, T, Moiseenkova-Bell, V.Y.
登録日2021-12-14
公開日2022-05-04
最終更新日2024-02-28
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献Structural basis of TRPV5 regulation by physiological and pathophysiological modulators.
Cell Rep, 39, 2022

 

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