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PDB: 123 件
1MZN
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BU of 1mzn by Molmil
CRYSTAL STRUCTURE at 1.9 ANGSTROEMS RESOLUTION OF THE HOMODIMER OF HUMAN RXR ALPHA LIGAND BINDING DOMAIN BOUND TO THE SYNTHETIC AGONIST COMPOUND BMS 649 AND A COACTIVATOR PEPTIDE
分子名称: 4-[2-(5,5,8,8-TETRAMETHYL-5,6,7,8-TETRAHYDRO-NAPHTHALEN-2-YL)-[1,3]DIOXOLAN-2-YL]-BENZOIC ACID, Nuclear receptor coactivator 2, RXR retinoid X receptor
著者Egea, P.F, Mitschler, A, Moras, D.
登録日2002-10-09
公開日2002-10-23
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Molecular Recognition of Agonist Ligands by RXRs
MOL.ENDOCRINOL., 16, 2002
5EUC
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BU of 5euc by Molmil
The role of the C-terminal region on the oligomeric state and enzymatic activity of Trypanosoma cruzi hypoxanthine phosphoribosyl transferase
分子名称: Hypoxanthine-guanine phosphoribosyltransferase
著者Valsecchi, W.M, Cousido-Siah, A, Mitschler, A, Podjarny, A, Delfino, J.M, Santos, J.
登録日2015-11-18
公開日2016-03-30
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献The role of the C-terminal region on the oligomeric state and enzymatic activity of Trypanosoma cruzi hypoxanthine phosphoribosyl transferase.
Biochim.Biophys.Acta, 1864, 2016
2R24
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BU of 2r24 by Molmil
Human Aldose Reductase structure
分子名称: Aldose reductase, IDD594, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
著者Blakeley, M.P, Ruiz, F, Cachau, R, Hazemann, I, Meilleur, F, Mitschler, A, Ginell, S, Afonine, P, Ventura, O.N, Cousido-Siah, A, Haertlein, M, Joachimiak, A, Myles, D, Podjarny, A.
登録日2007-08-24
公開日2008-12-23
最終更新日2024-02-21
実験手法NEUTRON DIFFRACTION (1.752 Å), X-RAY DIFFRACTION
主引用文献Quantum model of catalysis based on mobile proton revealed by subatomic X-Ray and neutron diffraction studies of h-Aldose Reductase
Proc.Natl.Acad.Sci.USA, 105, 2008
4QXI
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BU of 4qxi by Molmil
Crystal structure of human AR complexed with NADP+ and AK198
分子名称: Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, {2-[(4-amino-2-fluorobenzyl)carbamoyl]-5-chlorophenoxy}acetic acid
著者Cousido-Siah, A, Mitschler, A, Ruiz, F.X, Fanfrlik, J, Hobza, P, Podjarny, A.D.
登録日2014-07-21
公開日2015-07-22
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (0.867 Å)
主引用文献The Effect of Halogen-to-Hydrogen Bond Substitution on Human Aldose Reductase Inhibition.
Acs Chem.Biol., 10, 2015
6B9O
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BU of 6b9o by Molmil
Structure of GH 38 Jack Bean alpha-mannosidase
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-mannosidase from Canavalia ensiformis (jack bean), ZINC ION, ...
著者Howard, E, Cousido-Siah, A, Lepage, M, Bodlenner, A, Mitschler, A, Meli, A, De Riccardis, F, Izzo, I, Podjarny, A, Compain, P.
登録日2017-10-11
公開日2018-09-26
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.841 Å)
主引用文献Structural Basis of Outstanding Multivalent Effects in Jack Bean alpha-Mannosidase Inhibition.
Angew. Chem. Int. Ed. Engl., 57, 2018
6B9P
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Structure of GH 38 Jack Bean alpha-mannosidase in complex with a 36-valent iminosugar cluster inhibitor
分子名称: (2R,3R,4R,5S)-2-(hydroxymethyl)-1-{9-[4-(methoxymethyl)-1H-1,2,3-triazol-1-yl]nonyl}piperidine-3,4,5-triol, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-mannosidase from Canavalia ensiformis (jack bean), ...
著者Howard, E, Cousido-Siah, A, Lepage, M, Bodlenner, A, Mitschler, A, Meli, A, De Riccardis, F, Izzo, I, Podjarny, A, Compain, P.
登録日2017-10-11
公開日2018-09-26
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.996 Å)
主引用文献Structural Basis of Outstanding Multivalent Effects in Jack Bean alpha-Mannosidase Inhibition.
Angew. Chem. Int. Ed. Engl., 57, 2018
3LBD
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BU of 3lbd by Molmil
LIGAND-BINDING DOMAIN OF THE HUMAN RETINOIC ACID RECEPTOR GAMMA BOUND TO 9-CIS RETINOIC ACID
分子名称: (9cis)-retinoic acid, RETINOIC ACID RECEPTOR GAMMA
著者Klaholz, B.P, Renaud, J.-P, Mitschler, A, Moras, D, Structural Proteomics in Europe (SPINE)
登録日1998-02-04
公開日1999-03-02
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Conformational adaptation of agonists to the human nuclear receptor RAR gamma.
Nat.Struct.Biol., 5, 1998
5CE5
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BU of 5ce5 by Molmil
Probing the roles of two tryptophans surrounding the unique zinc coordination site in lipase family I.5
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 2,5,8,11,14,17-HEXAOXANONADECAN-19-OL, CALCIUM ION, ...
著者Sezerman, O.U, Podjarny, A.D, Emel, T, Cousido-Siah, A, Mitschler, A.
登録日2015-07-06
公開日2015-12-02
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Probing the roles of two tryptophans surrounding the unique zinc coordination site in lipase family I.5.
Proteins, 84, 2016
8GEW
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BU of 8gew by Molmil
H-FABP crystal soaked in a bromo palmitic acid solution
分子名称: 2-Bromopalmitic acid, Fatty acid-binding protein, heart, ...
著者Howard, E, Cousido-Siah, A, Alvarez, A, Espinosa, Y, Podjarny, A, Mitschler, A, Carlevaro, M.
登録日2023-03-07
公開日2023-08-30
最終更新日2024-04-17
実験手法X-RAY DIFFRACTION (0.97 Å)
主引用文献Lipid exchange in crystal-confined fatty acid binding proteins: X-ray evidence and molecular dynamics explanation.
Proteins, 91, 2023
3PP6
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BU of 3pp6 by Molmil
REP1-NXSQ fatty acid transporter Y128F mutant
分子名称: PALMITOLEIC ACID, ReP1-NCXSQ
著者Berberian, G, Bollo, M, Howard, E, Cousido-Siah, A, Mitschler, A, Ayoub, D, Sanglier-Cianferani, S, Van Dorsselaer, A, DiPolo, R, Beauge, L, Petrova, T, Schulze-Briese, C, Wang, M, Podjarny, A.
登録日2010-11-24
公開日2011-12-28
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural and functional studies of ReP1-NCXSQ, a protein regulating the squid nerve Na+/Ca2+ exchanger.
Acta Crystallogr.,Sect.D, 68, 2012
3PPT
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BU of 3ppt by Molmil
REP1-NXSQ fatty acid transporter
分子名称: PALMITOLEIC ACID, ReP1-NCXSQ
著者Berberian, G, Bollo, M, Howard, E, Cousido-Siah, A, Mitschler, A, Ayoub, D, Sanglier-Cianferani, S, Van Dorsselaer, A, DiPolo, R, Beauge, L, Petrova, T, Schulze-Briese, C, Wang, M, Podjarny, A.
登録日2010-11-25
公開日2011-12-21
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.28 Å)
主引用文献Structural and functional studies of ReP1-NCXSQ, a protein regulating the squid nerve Na+/Ca2+ exchanger.
Acta Crystallogr.,Sect.D, 68, 2012
3QF6
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BU of 3qf6 by Molmil
Neutron structure of type-III Antifreeze Protein allows the reconstruction of AFP-ice interface
分子名称: Type-3 ice-structuring protein HPLC 12
著者Howard, E.I, Blakeley, M.P, Haertlein, M, Petit-Haertlein, I, Mitschler, A, Fisher, S.J, Cousido-Siah, A, Salvay, A.G, Popov, A, Muller-Dieckmann, C, Petrova, T, Podjarny, A.
登録日2011-01-21
公開日2011-06-22
最終更新日2024-03-20
実験手法NEUTRON DIFFRACTION (1.85 Å)
主引用文献Neutron structure of type-III antifreeze protein allows the reconstruction of AFP-ice interface.
J.Mol.Recognit., 24, 2011
5HBF
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BU of 5hbf by Molmil
Crystal structure of human full-length chitotriosidase (CHIT1)
分子名称: Chitotriosidase-1, GLYCEROL
著者Fadel, F, Zhao, Y, Cousido-Siah, A, Ruiz, F.X, Mitschler, A, Podjarny, A.
登録日2015-12-31
公開日2016-05-04
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献X-Ray Crystal Structure of the Full Length Human Chitotriosidase (CHIT1) Reveals Features of Its Chitin Binding Domain.
Plos One, 11, 2016
5HR1
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BU of 5hr1 by Molmil
Crystal structure of thioredoxin L107A mutant
分子名称: COPPER (II) ION, Thioredoxin-1
著者Noguera, M.E, Vazquez, D.S, Howard, E.I, Cousido-Siah, A, Mitschler, A, Podjarny, A, Santos, J.
登録日2016-01-22
公開日2017-02-22
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.144 Å)
主引用文献Structural variability of E. coli thioredoxin captured in the crystal structures of single-point mutants.
Sci Rep, 7, 2017
5HR2
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BU of 5hr2 by Molmil
Crystal structure of thioredoxin L94A mutant
分子名称: COPPER (II) ION, Thioredoxin
著者Noguera, M.E, Vazquez, D.S, Howard, E.I, Cousido-Siah, A, Mitschler, A, Podjarny, A, Santos, J.
登録日2016-01-22
公開日2017-02-22
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Structural variability of E. coli thioredoxin captured in the crystal structures of single-point mutants.
Sci Rep, 7, 2017
5HR0
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BU of 5hr0 by Molmil
Crystal structure of thioredoxin E101G mutant
分子名称: COPPER (II) ION, Thioredoxin
著者Noguera, M.E, Vazquez, D.S, Howard, E.I, Cousido-Siah, A, Mitschler, A, Podjarny, A, Santos, J.
登録日2016-01-22
公開日2017-02-22
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.31 Å)
主引用文献Structural variability of E. coli thioredoxin captured in the crystal structures of single-point mutants.
Sci Rep, 7, 2017
5HR3
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BU of 5hr3 by Molmil
Crystal structure of thioredoxin N106A mutant
分子名称: COPPER (II) ION, ETHANOL, SULFATE ION, ...
著者Noguera, M.E, Vazquez, D.S, Howard, E.I, Cousido-Siah, A, Mitschler, A, Podjarny, A, Santos, J.
登録日2016-01-22
公開日2017-02-22
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.101 Å)
主引用文献Structural variability of E. coli thioredoxin captured in the crystal structures of single-point mutants.
Sci Rep, 7, 2017
1PWL
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BU of 1pwl by Molmil
Crystal structure of human Aldose Reductase complexed with NADP and Minalrestat
分子名称: 2[4-BROMO-2-FLUOROPHENYL)METHYL]-6-FLUOROSPIRO[ISOQUINOLINE-4-(1H),3'-PYRROLIDINE]-1,2',3,5'(2H)-TETRONE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, aldose reductase
著者El-Kabbani, O, Darmanin, C, Schneider, T.R, Hazemann, I, Ruiz, F, Oka, M, Joachimiak, A, Schulze-Briese, C, Tomizaki, T, Mitschler, A, Podjarny, A.
登録日2003-07-02
公開日2004-02-24
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.1 Å)
主引用文献Ultrahigh resolution drug design. II. Atomic resolution structures of human aldose reductase holoenzyme complexed with Fidarestat and Minalrestat: implications for the binding of cyclic imide inhibitors
PROTEINS, 55, 2004
1PWM
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BU of 1pwm by Molmil
Crystal structure of human Aldose Reductase complexed with NADP and Fidarestat
分子名称: (2S,4S)-2-AMINOFORMYL-6-FLUORO-SPIRO[CHROMAN-4,4'-IMIDAZOLIDINE]-2',5'-DIONE, CHLORIDE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
著者El-Kabbani, O, Darmanin, C, Schneider, T.R, Hazemann, I, Ruiz, F, Oka, M, Joachimiak, A, Schulze-Briese, C, Tomizaki, T, Mitschler, A, Podjarny, A.
登録日2003-07-02
公開日2004-02-24
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (0.92 Å)
主引用文献Ultrahigh resolution drug design. II. Atomic resolution structures of human aldose reductase holoenzyme complexed with Fidarestat and Minalrestat: implications for the binding of cyclic imide inhibitors
PROTEINS, 55, 2004
2AGT
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BU of 2agt by Molmil
Aldose Reductase Mutant Leu 300 Pro complexed with Fidarestat
分子名称: (2S,4S)-2-AMINOFORMYL-6-FLUORO-SPIRO[CHROMAN-4,4'-IMIDAZOLIDINE]-2',5'-DIONE, Aldose reductase, CHLORIDE ION, ...
著者Petrova, T, Steuber, H, Hazemann, I, Cousido-Siah, A, Mitschler, A, Chung, R, Oka, M, Klebe, G, El-Kabbani, O, Joachimiak, A, Podjarny, A.
登録日2005-07-27
公開日2005-09-20
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1 Å)
主引用文献Factorizing Selectivity Determinants of Inhibitor Binding toward Aldose and Aldehyde Reductases: Structural and Thermodynamic Properties of the Aldose Reductase Mutant Leu300Pro-Fidarestat Complex
J.Med.Chem., 48, 2005
6SJV
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BU of 6sjv by Molmil
Structure of HPV18 E6 oncoprotein in complex with mutant E6AP LxxLL motif
分子名称: Maltodextrin-binding protein,Protein E6,Ubiquitin-protein ligase E3A, ZINC ION, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose
著者Suarez, I.P, Cousido-Siah, A, Bonhoure, A, Kostmann, C, Mitschler, A, Podjarny, A, Trave, G.
登録日2019-08-14
公開日2019-09-04
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (2.029 Å)
主引用文献Cellular target recognition by HPV18 and HPV49 oncoproteins
To be published
6SJA
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BU of 6sja by Molmil
Structure of HPV16 E6 oncoprotein in complex with IRF3 LxxLL motif
分子名称: Maltose/maltodextrin-binding periplasmic protein,Interferon regulatory factor 3, Protein E6, ZINC ION, ...
著者Suarez, I.P, Cousido-Siah, A, Bonhoure, A, Mitschler, A, Podjarny, A, Trave, G.
登録日2019-08-13
公開日2019-09-04
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Deciphering de molecular and structural interaction between IRF3 and HPV16 E6
To be published
6SMV
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BU of 6smv by Molmil
Structure of HPV49 E6 protein in complex with MAML1 LxxLL motif
分子名称: DI(HYDROXYETHYL)ETHER, Maltose/maltodextrin-binding periplasmic protein,Protein E6,Mastermind-like protein 1, ZINC ION, ...
著者Suarez, I.P, Cousido-Siah, A, Bonhoure, A, Kostmann, C, Mitschler, A, Podjarny, A, Trave, G.
登録日2019-08-22
公開日2019-09-04
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.14 Å)
主引用文献Cellular target recognition by HPV18 and HPV49 oncoproteins
To be published
7Q46
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Crystal structure of RCC1-Like domain 2 of ubiquitin ligase HERC2 in complex with DXDKDED motif of pericentriolar material 1 protein
分子名称: CITRIC ACID, E3 ubiquitin-protein ligase HERC2, Pericentriolar material 1 protein
著者Demenge, A, Howard, E, Cousido-Siah, A, Mitschler, A, Podjarny, A, McEwen, A.G, Trave, G.
登録日2021-10-29
公開日2022-11-16
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.46002531 Å)
主引用文献Crystal structure of RCC1-Like domain 2 of ubiquitin ligase HERC2 in complex with DXDKDED motif of pericentriolar material 1 protein
To Be Published
7Q43
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Crystal structure of RCC1-Like domain 2 of ubiquitin ligase HERC2 in complex with DXDKDED motif of dedicator of cytokinesis protein 10
分子名称: CITRIC ACID, Dedicator of cytokinesis protein 10 peptide, E3 ubiquitin-protein ligase HERC2
著者Demenge, A, Howard, E, Cousido-Siah, A, Mitschler, A, Podjarny, A, McEwen, A.G, Trave, G.
登録日2021-10-29
公開日2022-11-16
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.40002346 Å)
主引用文献Crystal structure of RCC1-Like domain 2 of ubiquitin ligase HERC2 in complex with DXDKDED motif of dedicator of cytokinesis protein 10
To Be Published

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