5EUC

The role of the C-terminal region on the oligomeric state and enzymatic activity of Trypanosoma cruzi hypoxanthine phosphoribosyl transferase

Summary for 5EUC

Entry DOI	10.2210/pdb5euc/pdb
Descriptor	Hypoxanthine-guanine phosphoribosyltransferase (2 entities in total)
Functional Keywords	hprt, phosphoribosyltransferase, t. cruzi, quaternary structure, enzymatic activity modulation, stability, proteolysis, reversible oligomerization, disorder c-terminal region, bisphosphonates, transferase
Biological source	Trypanosoma cruzi (strain CL Brener)
Total number of polymer chains	4
Total formula weight	106666.24
Authors	Valsecchi, W.M.,Cousido-Siah, A.,Mitschler, A.,Podjarny, A.,Delfino, J.M.,Santos, J. (deposition date: 2015-11-18, release date: 2016-03-30, Last modification date: 2023-09-27)
Primary citation	Valsecchi, W.M.,Cousido-Siah, A.,Defelipe, L.A.,Mitschler, A.,Podjarny, A.,Santos, J.,Delfino, J.M. The role of the C-terminal region on the oligomeric state and enzymatic activity of Trypanosoma cruzi hypoxanthine phosphoribosyl transferase. Biochim.Biophys.Acta, 1864:655-666, 2016 Cited by PubMed: 26969784 DOI: 10.1016/j.bbapap.2016.03.005 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.65 Å)

Structure validation