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PDB: 24 件
6GA0
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Crystal structure of a thermophilic O6-alkylguanine-DNA alkyltransferase-derived self-labeling protein-tag in covalent complex with SNAP-Vista Green
分子名称: 5-[(4-methylphenyl)methylcarbamoyl]-2-(6-oxidanyl-3-oxidanylidene-4~{H}-xanthen-9-yl)benzoic acid, Methylated-DNA--protein-cysteine methyltransferase, SULFATE ION
著者Miggiano, R, Rossi, F, Rizzi, M.
登録日2018-04-11
公開日2018-05-09
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structure of a thermophilic O6-alkylguanine-DNA alkyltransferase-derived self-labeling protein-tag in covalent complex with a fluorescent probe.
Biochem. Biophys. Res. Commun., 500, 2018
6XXY
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BU of 6xxy by Molmil
Crystal structure of Haemophilus influenzae 3-isopropylmalate dehydrogenase in complex with O-isobutenyl oxalylhydroxamate.
分子名称: 2-(2-methylprop-2-enoxyamino)-2-oxidanylidene-ethanoic acid, 3-isopropylmalate dehydrogenase, MAGNESIUM ION, ...
著者Miggiano, R, Rossi, F, Martignon, S, Rizzi, M.
登録日2020-01-28
公開日2020-02-26
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.09 Å)
主引用文献Crystal structure of Haemophilus influenzae 3-isopropylmalate dehydrogenase (LeuB) in complex with the inhibitor O-isobutenyl oxalylhydroxamate.
Biochem.Biophys.Res.Commun., 524, 2020
4ZYE
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BU of 4zye by Molmil
Crystal structure of Sulfolobus solfataricus O6-methylguanine methyltransferase
分子名称: GLYCEROL, Methylated-DNA--protein-cysteine methyltransferase, NITRATE ION
著者Miggiano, R, Rossi, F, Rizzi, M.
登録日2015-05-21
公開日2015-08-12
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Structure-function relationships governing activity and stability of a DNA alkylation damage repair thermostable protein.
Nucleic Acids Res., 43, 2015
4ZYD
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BU of 4zyd by Molmil
Crystal structure of Sulfolobus solfataricus O6-methylguanine methyltransferase in complex with modified DNA
分子名称: DNA (5'-D(*GP*CP*CP*AP*TP*GP*(6OG)P*CP*TP*AP*GP*TP*A)-3'), DNA (5'-D(*TP*AP*CP*TP*AP*GP*CP*CP*AP*TP*GP*GP*C)-3'), Methylated-DNA--protein-cysteine methyltransferase
著者Miggiano, R, Rossi, F, Rizzi, M.
登録日2015-05-21
公開日2015-08-12
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.682 Å)
主引用文献Structure-function relationships governing activity and stability of a DNA alkylation damage repair thermostable protein.
Nucleic Acids Res., 43, 2015
4ZYH
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BU of 4zyh by Molmil
Crystal structure of Sulfolobus solfataricus O6-methylguanine methyltransferase C119L variant
分子名称: Methylated-DNA--protein-cysteine methyltransferase
著者Miggiano, R, Rossi, F, Rizzi, M.
登録日2015-05-21
公開日2015-08-12
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structure-function relationships governing activity and stability of a DNA alkylation damage repair thermostable protein.
Nucleic Acids Res., 43, 2015
4ZYG
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BU of 4zyg by Molmil
Crystal structure of methylated Sulfolobus solfataricus O6-methylguanine methyltransferase
分子名称: Methylated-DNA--protein-cysteine methyltransferase
著者Miggiano, R, Rossi, F, Rizzi, M.
登録日2015-05-21
公開日2015-08-12
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structure-function relationships governing activity and stability of a DNA alkylation damage repair thermostable protein.
Nucleic Acids Res., 43, 2015
4WX9
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Crystal structure of Mycobacterium tuberculosis OGT in complex with DNA
分子名称: DNA (5'-D(*GP*CP*CP*AP*TP*GP*(E1X)P*CP*TP*AP*GP*TP*A)-3'), DNA (5'-D(P*TP*AP*CP*TP*AP*GP*CP*CP*AP*TP*GP*GP*C)-3'), GLYCEROL, ...
著者Miggiano, R, Rossi, F, Garavaglia, S, Rizzi, M.
登録日2014-11-13
公開日2015-11-04
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Crystal structure of Mycobacterium tuberculosis O6-methylguanine-DNA methyltransferase protein clusters assembled on to damaged DNA.
Biochem.J., 473, 2016
5LLQ
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BU of 5llq by Molmil
Crystal structure of Sulfolobus solfataricus O6-methylguanine methyltransferase C119F variant
分子名称: GLYCEROL, Methylated-DNA--protein-cysteine methyltransferase
著者Miggiano, R, Rossi, F, Rizzi, M.
登録日2016-07-28
公開日2016-11-09
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Interdomain interactions rearrangements control the reaction steps of a thermostable DNA alkyltransferase.
Biochim.Biophys.Acta, 1861, 2016
4BHC
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BU of 4bhc by Molmil
CRYSTAL STRUCTURE OF THE M. TUBERCULOSIS O6-METHYLGUANINE METHYLTRANSFERASE R37L VARIANT
分子名称: METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE
著者Miggiano, R, Casazza, V, Garavaglia, S, Ciaramella, M, Perugino, G, Rizzi, M, Rossi, F.
登録日2013-04-02
公開日2013-04-17
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Biochemical and Structural Studies on the M. Tuberculosis O6-Methylguanine Methyltransferase and Mutated Variants.
J.Bacteriol., 195, 2013
4BHB
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BU of 4bhb by Molmil
Crystal structure of Mycobacterium tuberculosis O6-METHYLGUANINE METHYLTRANSFERASE
分子名称: GLYCEROL, METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE
著者Miggiano, R, Casazza, V, Garavaglia, S, Ciaramella, M, Perugino, G, Rizzii, M, Rossi, F.
登録日2013-04-02
公開日2013-04-17
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Biochemical and Structural Studies of the Mycobacterium Tuberculosis O6-Methylguanine Methyltransferase and Mutated Variants.
J.Bacteriol., 195, 2013
4WXC
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BU of 4wxc by Molmil
Crystal structure of Mycobacterium tuberculosis OGT-Y139F
分子名称: 1,2-ETHANEDIOL, Methylated-DNA--protein-cysteine methyltransferase
著者Miggiano, R, Rossi, F, Garavaglia, S, Rizzi, M.
登録日2014-11-13
公開日2015-11-04
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Crystal structure of Mycobacterium tuberculosis O6-methylguanine-DNA methyltransferase protein clusters assembled on to damaged DNA.
Biochem.J., 473, 2016
4WXD
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BU of 4wxd by Molmil
Crystal structure of Mycobacterium tuberculosis OGT-R37K
分子名称: GLYCEROL, Methylated-DNA--protein-cysteine methyltransferase
著者Miggiano, R, Rossi, F, Garavaglia, S, Rizzi, M.
登録日2014-11-13
公開日2015-11-04
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal structure of Mycobacterium tuberculosis O6-methylguanine-DNA methyltransferase protein clusters assembled on to damaged DNA.
Biochem.J., 473, 2016
6R77
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BU of 6r77 by Molmil
Crystal structure of trans-3-Hydroxy-L-proline dehydratase in complex with substrate - closed conformation
分子名称: 3-HYDROXYPROLINE, Proline racemase
著者Ferraris, D.M, Miggiano, R, Rizzi, M.
登録日2019-03-28
公開日2019-07-03
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structure of Thermococcus litoralis trans-3-hydroxy-l-proline dehydratase in the free and substrate-complexed form.
Biochem.Biophys.Res.Commun., 516, 2019
8OFW
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BU of 8ofw by Molmil
Crystal structure of the full-length dihydroorotate dehydrogenase from Mycobacterium tuberculosis
分子名称: Dihydroorotate dehydrogenase (quinone), FLAVIN MONONUCLEOTIDE
著者Alberti, M, Ferraris, D.M, Miggiano, R.
登録日2023-03-17
公開日2023-09-06
実験手法X-RAY DIFFRACTION (3.8 Å)
主引用文献Biochemical characterization of Mycobacterium tuberculosis dihydroorotate dehydrogenase and identification of a selective inhibitor.
Febs Lett., 597, 2023
8AES
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BU of 8aes by Molmil
Crystal structure of a thermophilic O6-alkylguanine-DNA alkyltransferase-derived self-labeling protein-tag
分子名称: Methylated-DNA--protein-cysteine methyltransferase
著者Genta, M, Perugino, G, Miggiano, R.
登録日2022-07-13
公開日2022-10-12
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献First thermostable CLIP- tag by rational design applied to an archaeal O 6 -alkyl-guanine-DNA-alkyl-transferase.
Comput Struct Biotechnol J, 20, 2022
6R76
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BU of 6r76 by Molmil
Crystal structure of trans-3-Hydroxy-L-proline dehydratase from Thermococcus litoralis - open conformation
分子名称: Proline racemase
著者Ferraris, D.M, Miggiano, R, Rizzi, M.
登録日2019-03-28
公開日2019-07-03
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structure of Thermococcus litoralis trans-3-hydroxy-l-proline dehydratase in the free and substrate-complexed form.
Biochem.Biophys.Res.Commun., 516, 2019
5MP7
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BU of 5mp7 by Molmil
Crystal structure of phosphoribosylpyrophosphate synthetase from Mycobacterium smegmatis
分子名称: ACETATE ION, Ribose-phosphate pyrophosphokinase
著者Donini, S, Garavaglia, S, Ferraris, D.M, Miggiano, R, Mori, S, Shibayama, K, Rizzi, M.
登録日2016-12-16
公開日2017-04-26
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Biochemical and structural investigations on phosphoribosylpyrophosphate synthetase from Mycobacterium smegmatis.
PLoS ONE, 12, 2017
8RAK
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BU of 8rak by Molmil
Crystal structure of human Dihydroorotate Dehydrogenase in complex with the inhibitor 2-Hydroxy-N-(2-isopropyl-5-methyl-4-(pyridin-4-yloxy)phenyl)pyrazolo[1,5-a]pyridine-3-carboxamide
分子名称: ACETATE ION, Dihydroorotate dehydrogenase (quinone), mitochondrial, ...
著者Alberti, M, Miggiano, R.
登録日2023-12-01
公開日2024-06-19
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献An alternative conformation of the N-terminal loop of human dihydroorotate dehydrogenase drives binding to a potent antiproliferative agent.
Acta Crystallogr D Struct Biol, 80, 2024
6T3E
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BU of 6t3e by Molmil
Structure of Thermococcus litoralis Delta(1)-pyrroline-2-carboxylate reductase in complex with NADH and L-proline
分子名称: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, DELTA1-pyrroline-2-carboxylate reductase, PROLINE
著者Ferraris, D.M, Miggiano, R, Ferrario, E, Rizzi, M.
登録日2019-10-10
公開日2020-05-13
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structure of Thermococcus litoralis Delta1-pyrroline-2-carboxylate reductase in complex with NADH and L-proline.
Acta Crystallogr D Struct Biol, 76, 2020
7Z6C
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BU of 7z6c by Molmil
Crystal structure of human Dihydroorotate Dehydrogenase in complex with the inhibitor 2-Hydroxy-N-(2-ispropyl-5-methyl-4-phenoxyphenyl)pyrazolo[1,5-a]pyridine-3-carboxamide.
分子名称: ACETATE ION, Dihydroorotate dehydrogenase (quinone), mitochondrial, ...
著者Alberti, M, Lolli, M.L, Boschi, D, Sainas, S, Rizzi, M, Ferraris, D.M, Miggiano, R.
登録日2022-03-11
公開日2022-10-12
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5- a ]pyridine Scaffold: SAR of the Aryloxyaryl Moiety.
J.Med.Chem., 65, 2022
7QPO
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Crystal structure of human trans-3-Hydroxy-L-proline dehydratase
分子名称: Trans-3-hydroxy-L-proline dehydratase
著者Ferrario, E, Miggiano, R, Rizzi, M, Ferraris, D.M.
登録日2022-01-05
公開日2022-08-17
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献The integration of AlphaFold-predicted and crystal structures of human trans -3-hydroxy-l-proline dehydratase reveals a regulatory catalytic mechanism.
Comput Struct Biotechnol J, 20, 2022
7R0U
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BU of 7r0u by Molmil
Structure of a cytosolic sulfotransferase of Anopheles gambiae (AGAP001425) in complex with 3'-phosphoadenosine 5-phosphate and vanillin.
分子名称: 4-hydroxy-3-methoxybenzaldehyde, ADENOSINE-3'-5'-DIPHOSPHATE, AGAP001425-PA, ...
著者Esposito Verza, A, Miggiano, R, Rizzi, R, Rossi, F.
登録日2022-02-02
公開日2022-08-10
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Biochemical and structural analysis of a cytosolic sulfotransferase of the malaria vector Anopheles gambiae overexpressed in the reproductive tissues.
Curr Res Struct Biol, 4, 2022
7R0O
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Structure of a cytosolic sulfotransferase of Anopheles gambiae (AGAP001425).
分子名称: AGAP001425-PA, CHLORIDE ION, GLYCEROL
著者Esposito Verza, A, Miggiano, R, Rizzi, R, Rossi, F.
登録日2022-02-02
公開日2022-08-10
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Biochemical and structural analysis of a cytosolic sulfotransferase of the malaria vector Anopheles gambiae overexpressed in the reproductive tissues.
Curr Res Struct Biol, 4, 2022
7R0S
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BU of 7r0s by Molmil
Structure of a cytosolic sulfotransferase of Anopheles gambiae (AGAP001425) in complex with vanillin
分子名称: 4-hydroxy-3-methoxybenzaldehyde, AGAP001425-PA, CHLORIDE ION, ...
著者Esposito Verza, A, Miggiano, R, Rizzi, R, Rossi, F.
登録日2022-02-02
公開日2022-08-10
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Biochemical and structural analysis of a cytosolic sulfotransferase of the malaria vector Anopheles gambiae overexpressed in the reproductive tissues.
Curr Res Struct Biol, 4, 2022

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件を2024-07-17に公開中

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