8RAK

Crystal structure of human Dihydroorotate Dehydrogenase in complex with the inhibitor 2-Hydroxy-N-(2-isopropyl-5-methyl-4-(pyridin-4-yloxy)phenyl)pyrazolo[1,5-a]pyridine-3-carboxamide

Summary for 8RAK

Entry DOI	10.2210/pdb8rak/pdb
Descriptor	Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, OROTIC ACID, ... (7 entities in total)
Functional Keywords	drug discovery, dhodh, inhibitor, leukemia, protein binding, flavoprotein
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	44138.65
Authors	Alberti, M.,Miggiano, R. (deposition date: 2023-12-01, release date: 2024-06-19)
Primary citation	Alberti, M.,Poli, G.,Broggini, L.,Sainas, S.,Rizzi, M.,Boschi, D.,Ferraris, D.M.,Martino, E.,Ricagno, S.,Tuccinardi, T.,Lolli, M.L.,Miggiano, R. An alternative conformation of the N-terminal loop of human dihydroorotate dehydrogenase drives binding to a potent antiproliferative agent. Acta Crystallogr D Struct Biol, 80:386-396, 2024 Cited by PubMed: 38805244 DOI: 10.1107/S2059798324004066 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation