8RAK
Crystal structure of human Dihydroorotate Dehydrogenase in complex with the inhibitor 2-Hydroxy-N-(2-isopropyl-5-methyl-4-(pyridin-4-yloxy)phenyl)pyrazolo[1,5-a]pyridine-3-carboxamide
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Dihydroorotate dehydrogenase (quinone), mitochondrial | polymer | 390 | 42636.4 | 1 | UniProt (Q02127) Pfam (PF01180) In PDB | Homo sapiens (human) | |
2 | A | FLAVIN MONONUCLEOTIDE | non-polymer | 456.3 | 1 | Chemie (FMN) | |||
3 | A | OROTIC ACID | non-polymer | 156.1 | 1 | Chemie (ORO) | |||
4 | A | ~{N}-(5-methyl-2-propan-2-yl-4-pyridin-4-yloxy-phenyl)-2-oxidanyl-pyrazolo[1,5-a]pyridine-3-carboxamide | non-polymer | 402.4 | 1 | Chemie (YMH) | |||
5 | A | ACETATE ION | non-polymer | 59.0 | 5 | Chemie (ACT) | |||
6 | A | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
7 | water | water | 18.0 | 292 | Chemie (HOH) |
Sequence modifications
A: 29 - 395 (UniProt: Q02127)
PDB | External Database | Details |
---|---|---|
Met 6 | - | initiating methionine |
Gly 7 | - | expression tag |
His 8 | - | expression tag |
His 9 | - | expression tag |
His 10 | - | expression tag |
His 11 | - | expression tag |
His 12 | - | expression tag |
His 13 | - | expression tag |
His 14 | - | expression tag |
His 15 | - | expression tag |
His 16 | - | expression tag |
His 17 | - | expression tag |
Ser 18 | - | expression tag |
Ser 19 | - | expression tag |
Gly 20 | - | expression tag |
His 21 | - | expression tag |
Ile 22 | - | expression tag |
Asp 23 | - | expression tag |
Asp 24 | - | expression tag |
Asp 25 | - | expression tag |
Asp 26 | - | expression tag |
Lys 27 | - | expression tag |
His 28 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 42636.4 | |
Non-Polymers* | Number of molecules | 10 |
Total formula weight | 1502.2 | |
All* | Total formula weight | 44138.6 |