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PDB: 19 results

4WZG
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BU of 4wzg by Molmil
Structure of human ATG101
Descriptor: Autophagy-related protein 101, BETA-MERCAPTOETHANOL
Authors:Michel, M, Weiergraeber, O.H.
Deposit date:2014-11-19
Release date:2015-06-17
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The mammalian autophagy initiator complex contains 2 HORMA domain proteins.
Autophagy, 11, 2015
5OHM
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BU of 5ohm by Molmil
K33-specific affimer bound to K33 diUb
Descriptor: K33-specific affimer, POLYETHYLENE GLYCOL (N=34), Polyubiquitin-C
Authors:Michel, M.A, Komander, D.
Deposit date:2017-07-17
Release date:2017-10-04
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:Ubiquitin Linkage-Specific Affimers Reveal Insights into K6-Linked Ubiquitin Signaling.
Mol. Cell, 68, 2017
9B0B
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BU of 9b0b by Molmil
Structure of Optineurin bound to HOIP NZF1 domain
Descriptor: E3 ubiquitin-protein ligase RNF31, Optineurin, TETRAETHYLENE GLYCOL, ...
Authors:Michel, M.A, Scutts, S, Komander, D.
Deposit date:2024-03-11
Release date:2024-07-31
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Linkage and substrate specificity conferred by NZF ubiquitin binding domains
To Be Published
9B0Z
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BU of 9b0z by Molmil
Structure of Optineurin bound to HOIP NZF1 domain and M1-linked diubiquitin, crystal form 2
Descriptor: E3 ubiquitin-protein ligase RNF31, Optineurin, Ubiquitin, ...
Authors:Michel, M.A, Scutts, S, Komander, D.
Deposit date:2024-03-12
Release date:2024-07-31
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:Linkage and substrate specificity conferred by NZF ubiquitin binding domains
To Be Published
9AVW
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BU of 9avw by Molmil
Structure of TAB2 NZF domain bound to K6 / Lys6-linked diubiquitin
Descriptor: SULFATE ION, TGF-beta-activated kinase 1 and MAP3K7-binding protein 2, Ubiquitin, ...
Authors:Michel, M.A, Scutts, S, Komander, D.
Deposit date:2024-03-05
Release date:2024-07-31
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (1.747 Å)
Cite:Structure of TAB2 NZF domain bound to K6 / Lys6-linked diubiquitin
To be published
9B12
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BU of 9b12 by Molmil
Structure of Optineurin bound to HOIP NZF1 domain and M1-linked diubiquitin, crystal form 1
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CHLORIDE ION, E3 ubiquitin-protein ligase RNF31, ...
Authors:Michel, M.A, Scutts, S, Komander, D.
Deposit date:2024-03-12
Release date:2024-07-31
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Linkage and substrate specificity conferred by NZF ubiquitin binding domains
To Be Published
9AZJ
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BU of 9azj by Molmil
Structure of ubiquitinated NEMO UBAN K285C-Ub G76C bound to HOIP NZF1
Descriptor: E3 ubiquitin-protein ligase RNF31, NF-kappa-B essential modulator, Ubiquitin, ...
Authors:Michel, M.A, Scutts, S, Komander, D.
Deposit date:2024-03-11
Release date:2024-07-31
Method:X-RAY DIFFRACTION (3.32 Å)
Cite:Structure of TAB2 NZF domain bound to K6 / Lys6-linked diubiquitin
To be published
9AVT
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BU of 9avt by Molmil
Structure of TAB2 NZF domain bound to K6 / Lys6-linked diubiquitin
Descriptor: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, SULFATE ION, TGF-beta-activated kinase 1 and MAP3K7-binding protein 2, ...
Authors:Michel, M.A, Scutts, S, Komander, D.
Deposit date:2024-03-04
Release date:2024-07-31
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structure of TAB2 NZF domain bound to K6 / Lys6-linked diubiquitin
To be published
5AF5
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BU of 5af5 by Molmil
Structure of Lys33-linked triUb S.G. P 212121
Descriptor: POLYUBIQUITIN-C
Authors:Michel, M.A, Elliott, P.R, Swatek, K.N, Simicek, M, Pruneda, J.N, Wagstaff, J.L, Freund, S.M.V, Komander, D.
Deposit date:2015-01-19
Release date:2015-03-25
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:Assembly and Specific Recognition of K29- and K33-Linked Polyubiquitin.
Mol.Cell, 58, 2015
5AF4
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BU of 5af4 by Molmil
Structure of Lys33-linked diUb
Descriptor: GLYCEROL, SULFATE ION, UBIQUITIN
Authors:Michel, M.A, Elliott, P.R, Swatek, K.N, Simicek, M, Pruneda, J.N, Wagstaff, J.L, Freund, S.M.V, Komander, D.
Deposit date:2015-01-19
Release date:2015-03-25
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Assembly and Specific Recognition of K29- and K33-Linked Polyubiquitin.
Mol.Cell, 58, 2015
5AF6
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BU of 5af6 by Molmil
Structure of Lys33-linked diUb bound to Trabid NZF1
Descriptor: TRABID, UBIQUITIN, ZINC ION
Authors:Michel, M.A, Elliott, P.R, Swatek, K.N, Simicek, M, Pruneda, J.N, Wagstaff, J.L, Freund, S.M.V, Komander, D.
Deposit date:2015-01-19
Release date:2015-03-25
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Assembly and Specific Recognition of K29- and K33-Linked Polyubiquitin.
Mol.Cell, 58, 2015
5OHL
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BU of 5ohl by Molmil
K6-specific affimer bound to K6 diUb
Descriptor: GLYCEROL, K6-specific affimer, POLYETHYLENE GLYCOL (N=34), ...
Authors:Michel, M.A, Komander, D.
Deposit date:2017-07-17
Release date:2017-10-04
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Ubiquitin Linkage-Specific Affimers Reveal Insights into K6-Linked Ubiquitin Signaling.
Mol. Cell, 68, 2017
5OHV
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BU of 5ohv by Molmil
K33-specific affimer bound to K33 diUb
Descriptor: GLYCEROL, K33-specific affimer, SULFATE ION, ...
Authors:Michel, M.A, Komander, D.
Deposit date:2017-07-18
Release date:2017-10-04
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.801 Å)
Cite:Ubiquitin Linkage-Specific Affimers Reveal Insights into K6-Linked Ubiquitin Signaling.
Mol. Cell, 68, 2017
6S4A
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BU of 6s4a by Molmil
Structure of human MTHFD2 in complex with TH9028
Descriptor: (2~{S})-2-[[5-[[2,4-bis(azanyl)-6-oxidanylidene-5~{H}-pyrimidin-5-yl]carbamoylamino]pyridin-2-yl]carbonylamino]-4-(1~{H}-1,2,3,4-tetrazol-5-yl)butanoic acid, (4S)-2-METHYL-2,4-PENTANEDIOL, Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, ...
Authors:Gustafsson, R, Scaletti, E.R, Bonagas, N, Gustafsson, N.M, Henriksson, M, Abdurakhmanov, E, Andersson, Y, Bengtsson, C, Borhade, S, Desroses, M, Farnegardh, K, Garg, N, Gokturk, C, Haraldsson, M, Iliev, P, Jarvius, M, Jemth, A.S, Kalderen, C, Karsten, S, Klingegard, F, Koolmeister, T, Martens, U, Llona-Minguez, S, Loseva, O, Marttila, P, Michel, M, Moulson, R, Nordstrom, H, Paulin, C, Pham, T, Pudelko, L, Rasti, A, Roos, A.K, Sarno, A, Sandberg, L, Scobie, M, Sjoberg, B, Svensson, R, Unterlass, J.E, Vallin, K, Vo, D, Wiita, E, Warpman-Berglund, U, Homan, E.J, Helleday, T, Stenmark, P.
Deposit date:2019-06-27
Release date:2021-07-07
Last modified:2024-06-19
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress.
Nat Cancer, 3, 2022
6S4F
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BU of 6s4f by Molmil
Structure of human MTHFD2 in complex with TH9619
Descriptor: (E,4S)-4-[[5-[2-[2,6-bis(azanyl)-4-oxidanylidene-1H-pyrimidin-5-yl]ethanoylamino]-3-fluoranyl-pyridin-2-yl]carbonylamino]pent-2-enedioic acid, ADENOSINE-5'-DIPHOSPHATE, Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, ...
Authors:Scaletti, E.R, Gustafsson, R, Bonagas, N, Gustafsson, N.M, Henriksson, M, Abdurakhmanov, E, Andersson, Y, Bengtsson, C, Borhade, S, Desroses, M, Farnegardh, K, Garg, N, Gokturk, C, Haraldsson, M, Iliev, P, Jarvius, M, Jemth, A.S, Kalderen, C, Karsten, S, Klingegard, F, Koolmeister, T, Martens, U, Llona-Minguez, S, Loseva, O, Marttila, P, Michel, M, Moulson, R, Nordstrom, H, Paulin, C, Pham, T, Pudelko, L, Rasti, A, Roos, A.K, Sarno, A, Sandberg, L, Scobie, M, Sjoberg, B, Svensson, R, Unterlass, J.E, Vallin, K, Vo, D, Wiita, E, Warpman-Berglund, U, Homan, E.J, Helleday, T, Stenmark, P.
Deposit date:2019-06-27
Release date:2021-07-07
Last modified:2024-06-19
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress.
Nat Cancer, 3, 2022
6S4E
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BU of 6s4e by Molmil
Structure of human MTHFD2 in complex with TH7299
Descriptor: (2S)-2-[[4-[[2,4-bis(azanyl)-6-oxidanylidene-1H-pyrimidin-5-yl]carbamoylamino]phenyl]carbonylamino]pentanedioic acid, Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial, ...
Authors:Gustafsson, R, Scaletti, E.R, Bonagas, N, Gustafsson, N.M, Henriksson, M, Abdurakhmanov, E, Andersson, Y, Bengtsson, C, Borhade, S, Desroses, M, Farnegardh, K, Garg, N, Gokturk, C, Haraldsson, M, Iliev, P, Jarvius, M, Jemth, A.S, Kalderen, C, Karsten, S, Klingegard, F, Koolmeister, T, Martens, U, Llona-Minguez, S, Loseva, O, Marttila, P, Michel, M, Moulson, R, Nordstrom, H, Paulin, C, Pham, T, Pudelko, L, Rasti, A, Roos, A.K, Sarno, A, Sandberg, L, Scobie, M, Sjoberg, B, Svensson, R, Unterlass, J.E, Vallin, K, Vo, D, Wiita, E, Warpman-Berglund, U, Homan, E.J, Helleday, T, Stenmark, P.
Deposit date:2019-06-27
Release date:2021-07-07
Last modified:2024-06-19
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress.
Nat Cancer, 3, 2022
5G2N
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BU of 5g2n by Molmil
X-ray structure of PI3Kinase Gamma in complex with Copanlisib
Descriptor: 2-azanyl-~{N}-[7-methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl]pyrimidine-5-carboxamide, PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM, SULFATE ION
Authors:Schaefer, M, Scott, W.J, Hentemann, M.F, Rowley, R.B, Bull, C.O, Jenkins, S, Bullion, A.M, Johnson, J, Redman, A, Robbins, A.H, Esler, W, Fracasso, R.P, Garrison, T, Hamilton, M, Michels, M, Wood, J.E, Wilkie, D.P, Xiao, H, Levy, J, Liu, N, Stasik, E, Brands, M, Lefranc, J.
Deposit date:2016-04-11
Release date:2016-04-20
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.68 Å)
Cite:Discovery and Sar of Novel 2,3-Dihydroimidazo(1,2-C)Quinazoline Pi3K Inhibitors: Identification of Copanlisib (Bay 80-6946)
Chemmedchem, 11, 2016
1BJG
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BU of 1bjg by Molmil
D221(169)N MUTANT DOES NOT PROMOTE OPENING OF THE COFACTOR IMIDAZOLIDINE RING
Descriptor: 5,10-METHYLENE-6-HYDROFOLIC ACID, 5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE
Authors:Sage, C.R, Michelitsch, M.D, Finer-Moore, J, Stroud, R.M.
Deposit date:1998-06-25
Release date:1998-11-04
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:D221 in thymidylate synthase controls conformation change, and thereby opening of the imidazolidine.
Biochemistry, 37, 1998
1DNA
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BU of 1dna by Molmil
D221(169)N MUTANT DOES NOT PROMOTE OPENING OF THE COFACTOR IMIDAZOLIDINE RING
Descriptor: 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE
Authors:Sage, C.R, Michelitsch, M.D, Finer-Moore, J, Stroud, R.M.
Deposit date:1998-06-25
Release date:1998-11-04
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:D221 in thymidylate synthase controls conformation change, and thereby opening of the imidazolidine.
Biochemistry, 37, 1998

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